Photodynamic and light independent action of 8 to 2 carboxylic free porphyrins on some haem-enzymes

Afonso, Susana

doi:10.1016/s1357-2725(01)00084-x

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…To date, photoreactions of metal-porphyrins have attracted many interests in photodynamic therapy for tumor, 1,2) care of porphyrias 3) and activities of biomimetics. 4,5) The investigators frequently discussed that the vital activities of metalporphyrins are concerned with active oxygens.…”

Section: ؉ -Tetrakis(4-methylpyridyl)-porphine In the Presence Of Almentioning

confidence: 99%

“…Water soluble In-and Ga-TMPyP ([In-and Ga-TMPyP-(H 2 O) 3 Cl]Cl 4 ) were prepared from commercially available H 2 -TMPyP and InCl 3 (GaCl 3 ) according as the literature method. [8][9][10] Human and bovine serum albumins (1ϫcrystal-lized, HSA and BSA) were purchased from Sigma Chemical Co. Ltd., and chicken egg albumin (5ϫcrystallized, EA) from Seikagaku Co. Ltd. Other chemicals were of analytical or of reagent grade.…”

Section: ؉ -Tetrakis(4-methylpyridyl)-porphine In the Presence Of Almentioning

confidence: 99%

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Photoreaction Generating Active Oxygens of In3+-Tetrakis(4-methylpyridyl)-porphine in the Presence of Albumins.

Mifune

Asahara

Hinokiyama

et al. 2002

CHEMICAL & PHARMACEUTICAL BULLETIN

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The complex formation of In 3؉-tetrakis(4-N-methylpyridyl)-porphine (In-TMPyP) with albumin was studied by resonance Raman spectroscopy. Albumin coordinated to In 3؉ through the -S ؊ group(s). The photoreaction was investigated using the visible spectral change and In-TMPyP-thiourea complex was used as a model. It was demonstrated that the complex in a weak basic solution (pH 8.5) is excited by light and the excited complex converts oxygen to superoxide anion, which finally cleavages the porphine ring of In-TMPyP.

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Section: ؉ -Tetrakis(4-methylpyridyl)-porphine In the Presence Of Almentioning

confidence: 99%

Section: ؉ -Tetrakis(4-methylpyridyl)-porphine In the Presence Of Almentioning

confidence: 99%

Photoreaction Generating Active Oxygens of In3+-Tetrakis(4-methylpyridyl)-porphine in the Presence of Albumins.

Mifune

Asahara

Hinokiyama

et al. 2002

CHEMICAL & PHARMACEUTICAL BULLETIN

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Pharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders

2017

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Afamelanotide, the first α-melanocyte-stimulating hormone (MSH) analogue, synthesized in 1980, was broadly investigated in all aspects of pigmentation because its activity and stability were higher than the natural hormone. Afamelanotide binds to the melanocortin-1 receptor (MC1R), and MC1R signaling increases melanin synthesis, induces antioxidant activities, enhances DNA repair processes and modulates inflammation. The loss-of-function variants of the MC1R present in fair-skinned Caucasians are less effectively activated by the natural hormone. Afamelanotide was the first α-MSH analogue to be applied to human volunteers. Ten daily doses of between 0.08 and 0.21 mg/kg in saline injected subcutaneously resulted in long-lasting skin pigmentation and enabled basic pharmacokinetics. Subcutaneous application had full bioavailability, but neither oral nor transdermal application resulted in measurable plasma concentrations or pigmentation response. Two trials in human volunteers showed that neither MC1R variants nor fair skin reduced the afamelanotide-induced increase in skin pigmentation. A controlled-release formulation optimizes administration in man and is effective at a lower dose than the daily saline injections. Promising therapeutic results were published in polymorphic light eruption, erythropoietic protoporphyria (EPP), solar urticaria, Hailey-Hailey disease and vitiligo. In 2014, afamelanotide was approved by the European Medicines Agency for the prevention of phototoxicity in adult patients with EPP. No late effects were reported in volunteers 25 years after the first exposure or after continuous long-term application of up to 8 years in EPP patients, and an immunogenic potential has been excluded. Generally, adverse effects were benign in all trials.

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Meso-substituted tetra-cationic porphyrins photosensitize the death of human fibrosarcoma cells via lysosomal targeting

Ricchelli

Franchi

Miotto

et al. 2005

The International Journal of Biochemistry & Cell Biology

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Photodynamic and light independent action of 8 to 2 carboxylic free porphyrins on some haem-enzymes

Cited by 4 publications

References 17 publications

Photoreaction Generating Active Oxygens of In3+-Tetrakis(4-methylpyridyl)-porphine in the Presence of Albumins.

Photoreaction Generating Active Oxygens of In3+-Tetrakis(4-methylpyridyl)-porphine in the Presence of Albumins.

Pharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders

Meso-substituted tetra-cationic porphyrins photosensitize the death of human fibrosarcoma cells via lysosomal targeting

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