Photodynamic and antiangiogenic activities of parietin liposomes in triple negative breast cancer

Ayoub, Abdallah Mohamed; Amin, Muhammed U.; Ambreen, Ghazala; Dayyih, Alice Abu; Abdelsalam, Ahmed M.; Somaida, Ahmed; Engelhardt, Konrad; Wojcik, Matthias; Schäfer, Jens

doi:10.1016/j.msec.2021.112543

Cited by 16 publications

(11 citation statements)

References 58 publications

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“…A large number of studies have found that the level of serum uric acid is positively correlated with the occurrence of colorectal cancer, liver cancer, kidney cancer, melanoma, and head and neck tumors, but its relationship with the prognosis of HCC is still unclear ( Ayoub et al, 2021 ; Wang H. et al, 2022 ; Wang J. et al, 2022 ). In our study, we found that the level of serum uric acid was positively correlated with the prognosis of HCC, suggesting that serum uric acid may be used as an index to predict the prognosis of patients with HCC.…”

Section: Discussionmentioning

confidence: 99%

A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma

et al. 2022

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Background: Hepatocellular carcinoma (HCC) is regarded as one of the most common cancers in the world with a poor prognosis. Patients with HCC often have abnormal purine and uric acid metabolism, but their relationship with prognosis is unclear.Methods: Here, we collected the data of peripheral blood uric acid and clinical data in 50 patients with HCC and analyzed the relationship with prognosis. At the same time, the transcriptome sequencing data of TCGA and GEO databases were collected to analyze the changes in purine metabolic pathway activity and construct a prognosis prediction model. Based on the prognosis prediction model related to purine metabolism, we further looked for the differences in the immune microenvironment and molecular level and provided possible drug targets.Results: We found that the level of serum uric acid was positively correlated with the prognosis of HCC. At the same time, purine metabolism and purine biosynthesis pathway activities were significantly activated in patients with a poor prognosis of HCC. The prognosis prediction model of HCC based on purine metabolism and purine biosynthesis pathway can accurately evaluate the prognosis of patients with HCC. Meanwhile, we found that there were significant changes in tumor immune infiltration microenvironment and biological function at the molecular level in patients with over-activation of purine metabolism and purine biosynthesis pathway. In addition, we found that uric acid level was positively correlated with peripheral blood leukocytes in HCC patients.Conclusion: In this study, we found that the level of peripheral blood uric acid in patients with HCC is correlated with their prognosis. The prognosis of patients with HCC can be accurately predicted through the metabolic process of uric acid and purine.

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Section: Discussionmentioning

confidence: 99%

A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma

et al. 2022

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“…The photodynamic activity of PTN/HP-β-CD complexes was evaluated by analyzing the singlet oxygen generation ( 1 O2) using uric acid (UA), and as previously mentioned, using rose bengal (RB) as a standard photosensitizer with a reported singlet oxygen quantum yield of 0.75 in water [19]. Briefly, uric acid (100 µ M) was mixed with PTN (10 µ g/mL) and irradiated 5 times for 1 min by a blue LED (λirr = 457 nm, irradiance = 220.2 W/m 2 , Lumundus, Eisenach, Germany).…”

Section: Singlet Oxygen Quantum Yieldmentioning

confidence: 99%

“…This can be performed by monitoring the decay curves of UA absorbance as a function of irradiation time. Following the established measuring procedure [19], the decomposition of UA upon exposure to generated singlet oxygen was employed to measure singlet oxygen generation. UA was selected because it does not absorb light in the blue region, specifically at the PTN irradiation wavelength.…”

Section: Singlet Oxygen Quantum Yieldmentioning

confidence: 99%

“…Xanthoria parietina has been used in traditional medicine for kidney problems and menstrual disorders and as a painkiller [16]. Although PTN offers several activities, including antibacterial and antifungal [14], and has antitumoral [17] and other photosensitizing properties [18,19], it was studied only in organic solvents and is not applicable in clinical use. Like many lipophilic PSs, PTN aggregates unduly in the biological environment, losing its singlet oxygen quantum yield and limiting its routine use.…”

Section: Introductionmentioning

confidence: 99%

“…Like many lipophilic PSs, PTN aggregates unduly in the biological environment, losing its singlet oxygen quantum yield and limiting its routine use. To solve these drawbacks, we recently reported the encapsulation of PTN into liposomes to promote its aqueous solubility and stability in the biological milieu and enhance selectivity and delivery to the targeted cells [19]. However, its high hydrophobicity does not favor entrapping a higher amount in the lipid bilayer.…”

Section: Introductionmentioning

confidence: 99%

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Parietin Cyclodextrin-Inclusion Complex as an Effective Formulation for Bacterial Photoinactivation

et al. 2022

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Multidrug resistance in pathogenic bacteria has become a significant public health concern. As an alternative therapeutic option, antimicrobial photodynamic therapy (aPDT) can successfully eradicate antibiotic-resistant bacteria with a lower probability of developing resistance or systemic toxicity commonly associated with the standard antibiotic treatment. Parietin (PTN), also termed physcion, a natural anthraquinone, is a promising photosensitizer somewhat underrepresented in aPDT because of its poor water solubility and potential to aggregate in the biological environment. This study investigated whether the complexation of PTN with (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) could increase its solubility, enhance its photophysical properties, and improve its phototoxicity against bacteria. At first, the solubilization behavior and complexation constant of the PTN/HP-β-CD inclusion complexes were evaluated by the phase solubility method. Then, the formation and physicochemical properties of PTN/HP-β-CD complexes were analyzed and confirmed in various ways. At the same time, the photodynamic activity was assessed by the uric acid method. The blue light-mediated photodegradation of PTN in its free and complexed forms were compared. Complexation of PTN increased the aqueous solubility 28-fold and the photostability compared to free PTN. PTN/HP-β-CD complexes reduce the bacterial viability of Staphylococcus saprophyticus and Escherichia coli by > 4.8 log and > 1.0 log after irradiation, respectively. Overall, the low solubility, aggregation potential, and photoinstability of PTN were overcome by its complexation in HP-β-CD, potentially opening up new opportunities for treating infections caused by multidrug-resistant bacteria.

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Organic Nanoparticles in Anti-angiogenic Cancer Therapy

Mukherjee

Madamsetty

2022

Nanoparticles in Angiogenesis and Cancer

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Photodynamic and antiangiogenic activities of parietin liposomes in triple negative breast cancer

Cited by 16 publications

References 58 publications

A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma

A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma

Parietin Cyclodextrin-Inclusion Complex as an Effective Formulation for Bacterial Photoinactivation

Organic Nanoparticles in Anti-angiogenic Cancer Therapy

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