Photodynamic acidification therapy to reduce triple negative breast cancer growth in vivo.

Kadri, Nuha Buchanan; Gdovin, Matthew J.; Alyassin, Nizar; Avila, J. Martinez; Cruz, A. B.; Cruz, Louis; Holliday, Steve; Jordan, Zachary; Ruiz, C.; Watts, Jennifer

doi:10.1200/jco.2016.34.15_suppl.e12574

Cited by 4 publications

(6 citation statements)

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“…pH variations are associated with different human diseases, like acidosis in tumor development 128 – 130 , and also in ischemic stroke, neurodegenerative disease, seizures, and respiratory control 131 , 132 . Indeed, pH modification can be envisaged as a therapeutic approach for these pathologies; for instance, non-invasive photodynamic therapy (PDT) has been shown to cause focal intracellular acidification in cancer cells 133 , 134 .…”

Section: Physiological Evidence and Compatibility With His Phosphorylmentioning

confidence: 99%

Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes

Adam

Hunter

2018

Laboratory Investigation

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Protein phosphorylation is the most common type of post-translational modification in eukaryotes. The phosphoproteome is defined as the complete set of experimentally detectable phosphorylation sites present in a cell’s proteome under various conditions. However, we are still far from identifying all the phosphorylation sites in a cell mainly due to the lack of information about phosphorylation events involving residues other than Ser, Thr and Tyr. Four types of phosphate-protein linkage exist and these generate nine different phosphoresidues – pSer, pThr, pTyr, pHis, pLys, pArg, pAsp, pGlu, and pCys. Most of the effort in studying protein phosphorylation has been focused on Ser, Thr and Tyr phosphorylation. The recent development of 1- and 3-pHis monoclonal antibodies promises to increase our understanding of His phosphorylation and the kinases and phosphatases involved. Several His kinases are well defined in prokaryotes, especially those involved in Two-Component System (TCS) signaling. However in higher eukaryotes, NM23, a protein originally characterized as a nucleoside diphosphate kinase, is the only characterized protein-histidine kinase. This ubiquitous and conserved His kinase autophosphorylates its active site His, and transfers this phosphate either onto a nucleoside diphosphate or onto a protein His residue. Studies of NM23 protein targets using newly developed anti-pHis antibodies will surely help illuminate the elusive His phosphorylation-based signaling pathways. This review discusses the role that the NM23/NME/NDPK phosphotransferase plays, how the addition of the pHis phosphoproteome will expand the phosphoproteome, and make His phosphorylation part of the global phosphorylation world. It also summarizes why our understanding of phosphorylation is still largely restricted to the acid stable phosphoproteome, and highlights the study of NM23 histidine kinase as an entrée into the world of histidine phosphorylation.

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Section: Physiological Evidence and Compatibility With His Phosphorylmentioning

confidence: 99%

Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes

Adam

Hunter

2018

Laboratory Investigation

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“…The production of protons from ethyl alcohol alteration to its anion as metastable state, Figure 4, has enthalpy value of 317.340 k cal mol −1 which corresponds to 13.774241 eV per ethyl alcohol molecule. The production of protons from ethyl alcohol may be performed by the aid of ADH enzyme as has been suggested by Gdovin [12] and Wojciech [11]. …”

Section: Breast Cancer Treatmentmentioning

confidence: 99%

“…Matthew Gdovin and others have found out an experimental method to kill the cancer cells in two hour by injection of ethanolic solution of nitrobenzaldehyde and stay sometimes to let the solution diffuses in the breast tumor and then aim uv-light on the tumor for about two hours causing the cancerous cells become very acidic inside then the breast tumor disappears because the carcinogenic cells commit suicide in the strong acidic medium as explained by Gdovin group [12]. So the ethanolic solution of derivatives para, meta and ortho of nitrobenzaldehyde have been studied by time dependent TD-DFT/6-31**G calculations [15] to study the excited states in these molecules.…”

Section: Breast Cancer Treatmentmentioning

confidence: 99%

“…This means that the ratio between its anions and its molecular forms is very low even at blood pH = 7.4, therefore the loss of protons from ethanol molecule is weak possibility except by the aid of ADH enzyme in cancerous cells which performs much effort to do, as reported by Wojciech [11] . So, the cure of breast cancer tumor by Matthew Gdovin [12] is due to the electron transfer from the second and third excited states of para and ortho derivatives of nitrobenzaldehyde to the cationic guanine in the cancerous cells which may be enhanced by the proton production from ethyl alcohol and its main metabolite acetaldehyde by the enzymes ALDH whose activity is much lower than ADH enzymes [11], Figure 3. Therefore, it can be suggested that the electron transfer is much preferred than proton transfer in the cure of breast cancer the most aggressive types of cancer and one of the hardest to treat.…”

Section: Breast Cancer Treatmentmentioning

confidence: 99%

“…This can be called photodynamic therapy, most of the current methods of using it to involve creating a particular deadly form of oxygen or heating up particles or chemicals in tumors. Now, a researcher Mat-thew Gdovin has found a way to use the therapy to alter the pH of tumors so that they commit suicide without harming the rest of the body [12].…”

Section: Introductionmentioning

confidence: 99%

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DFT-Comparison of Anti-Cancer Effect of Ibuprofen Drug Anions and Breast Cancer Treatment by Ethanolic Solution of Nitrobenzaldehyde in Two Hours

El‐Shahawy

2017

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Focusing our DFT calculations on the carboxylic acid drugs such as ibuprofen drug (IBF), it has been concluded that the anions of these types of drugs have the spontaneous electron donor character to all the carcinogenic cells of electron deficiency in their nuclei. Due to the spontaneity of electron transfer of anions, it has been found clinically that ibuprofen drug cures cancers of colon, protostate, lung and breast. The breast cancer treatment of Matthew Gdovin group in two hours by injection of ethanolic solution of nitrobenzaldehyde in the breast tumor in presence of uv-irradiation has been studied from TD-DFT point of view; the excited states of these molecules in presence of uv-irradiation act as electron donors to the cancerous cells to compensate the electron deficiency. Finally, it has been concluded that the electron transfer is the main cause of the breast cancer treatment which is the most aggressive type of cancers and is one of the hardest to treat.

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Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases

Harguindey¹,

Stanciu²,

Devesa

et al. 2017

Seminars in Cancer Biology

127

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During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed proton gradient of cancer cells has resulted in a new and integral pH-centric paradigm in oncology, a translational model embracing from cancer etiopathogenesis to treatment. The abnormalities of intracellular alkalinization along with extracellular acidification of all types of solid tumors and leukemic cells have never been described in any other disease and now appear to be a specific hallmark of malignancy. As a consequence of this intracellular acid-base homeostatic failure, the attempt to induce cellular acidification using proton transport inhibitors and other intracellular acidifiers of different origins is becoming a new therapeutic concept and selective target of cancer treatment, both as a metabolic mediator of apoptosis and in the overcoming of multiple drug resistance (MDR). Importantly, there is increasing data showing that different ion channels contribute to mediate significant aspects of cancer pH regulation and etiopathogenesis. Finally, we discuss the extension of this new pH-centric oncological paradigm into the opposite metabolic and homeostatic acid-base situation found in human neurodegenerative diseases (HNDDs), which opens novel concepts in the prevention and treatment of HNDDs through the utilization of a cohort of neural and non-neural derived hormones and human growth factors.

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Photodynamic acidification therapy to reduce triple negative breast cancer growth in vivo.

Cited by 4 publications

References 0 publications

Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes

Histidine kinases and the missing phosphoproteome from prokaryotes to eukaryotes

DFT-Comparison of Anti-Cancer Effect of Ibuprofen Drug Anions and Breast Cancer Treatment by Ethanolic Solution of Nitrobenzaldehyde in Two Hours

Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases

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