Photodissociation of nitric oxide from designed ruthenium nitrosyl complex: Studies on wound healing and antibacterial activity

Anti-bacterial, anti-biofilm and synergistic effects of phenazine-based ruthenium(ii) complexes

“…It is noteworthy that there are not many nitrosyl ruthenium compounds with low MIC/MBC, where most of them do not have any measurable MIC/MBC or values > 25 μg mL −1 . 71,72 A recent paper has pointed out that NO can indeed be beneficial to certain bacteria ( e.g. , Staphylococcus aureus ) that can use it to lower the efficacy of ROS produced by antibiotic agents.…”

“…It is noteworthy that there are not many nitrosyl ruthenium compounds with low MIC/MBC, where most of them do not have any measurable MIC/MBC or values > 25 µg mL −1 . 71,72 A recent paper has pointed out that NO can indeed be beneficial to certain bacteria (e.g., Staphylococcus aureus) that can use it to lower the efficacy of ROS produced by antibiotic agents. 21 These results might support the lack of efficacy of many NO donor systems as antibacterial agents, reinforcing our results that a stable nitrosyl compound can be better indeed.…”

Gas Therapy: Generating, Delivery, and Biomedical Applications

“…Loading Ru nitrosyl compound into lipid bilayers liposomes via hydrophobic interaction From 3.39 to 7.71 µM with various amounts of NO donor (14.7-50 µM) 120 min -Water-insoluble Ru nitrosyl compound was loaded into liposomes with a hydrophilic surface to improve biocompatibility [197] Newly designed bidentate ligands From 1.56 to 5.63 µM -Antibacterial activity and wound healing 50 μg/mL of the NO donor showed significant wound healing and inhibited more than 99% of bacteria after 1.5 h [198] Synthesizing an amphiphilic terpyridine ligand containing RU nitrosyl complex Quantum yield between 3.19×10 -3 -0.12 𝑡 1/2 = 0.4 -5.5 min…”

Photorelease of Nitric Oxide (NO) in Mono- and Bimetallic Ruthenium Nitrosyl Complexes: A Photokinetic Investigation with a Two-Step Model

“…Nitric oxide (NO • ) has gradually been recognized to play a major role in numerous physiological functions, such as neurotransmission, blood pressure regulation, stimulation of immune response, and cytotoxic activity in tumor cells by apoptosis. − Therefore, exogenous NO • donors have been intensively investigated for various therapeutic applications . Among them, ruthenium nitrosyl (RuNO) complexes appear especially appealing due to their generally low toxicity, good stability in biological medium, and, furthermore, their capability to release NO • under light irradiation in the λ = 300–500 nm domain, exclusively, taking advantage of the noninvasive and highly controllable characteristics of light. − However, and to be fully applicable, the NO • photorelease should be achieved in the λ = 600–1300 nm therapeutic window of relative transparency of biological tissues …”