Photodimerisation of a styrylpyrazine amphiphile suppresses the release of glucose entrapped in its mixed vesicle with DPPC

Park, Jong-Mok; Aoyama, Shigeru; Zhang, Wanbin; Nakatsuji, Yohji; Ikeda, Isao

doi:10.1039/a907923h

Cited by 9 publications

(10 citation statements)

References 11 publications

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“…Effective DDSs must be able to entrap the drug, to retain it without any leakage and to release it when the proper condition or environment is reached. In this context, many attempts have been made by designing liposomes and vesicles sensitive to a change in the surrounding conditions, such as pH,3–10 temperature,11–13 UV light14–16 and to the presence of specific molecules 17, 18. Especially, the pH‐sensitive liposomes and vesicles have been noteworthy as DDSs because the pH value around any damaged tissue is different from that around other normal tissues 19–23…”

Section: Introductionmentioning

confidence: 99%

Light Scattering as Spectroscopic Tool for the Study of Disperse Systems Useful in Pharmaceutical Sciences

Villari

Micali

2008

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Light Scattering as Spectroscopic Tool for the Study of Disperse Systems Useful in Pharmaceutical Sciences

Villari

Micali

2008

Journal of Pharmaceutical Sciences

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“…Materials with such abilities are broadly termed smart materials or stimuli-responsive materials. 1Ϫ4 Materials that can respond to various types of stimulus such as mechanical stress, 5 temperature, 6,7 pH, 8Ϫ12 electric field, 13 magnetic field, 14 redox potentials, 15 light, 16,17 and certain chemicals 18,19 have been synthesized in the past. 18,19 Organic materials such as polyelectrolyte multilayers, 20 block copolymers, 21 phospholipids, 22 and gels 23 possess individual molecular components that can respond to an external stimulus by significantly altering their own physical or chemical properties.…”

mentioning

confidence: 99%

pH-Sensitive Breathing of Clay within the Polyelectrolyte Matrix

2010

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Stimuli-responsive organic-inorganic hybrid spheres were synthesized by coating the colloidal polystyrene spheres with polyelectrolyte-protected aminoclay, Mg phyllo(organo)silicate layers in a layer-by-layer method. The clay layers are sandwiched between the polyelectrolyte layers. The aminoclay swells in water due to protonation of amino groups, and the degree of swelling depends on the pH of the medium. As a result, the hybrid spheres undergo a size change up to 60% as the pH is changed from 9 to 4. The stimuli-responsive property of the hybrid spheres was used for the release of ibuprofen and eosin at different pH.

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“…35 Polymerisable lipids of the second kind are often unstable because the polymerised lipid tends to adopt a non-bilayer structure which leads to leakage of the liposome contents and (in some cases) liposome aggregation and fusion. 43, 44 This destabilisation opens challenging possibilities for photo-induced liposomal contents release and/or fusion.…”

Section: Preparation Of Bilayer Vesicles With An Oligomerised Inner M...mentioning

confidence: 99%

Vesicles formed from phospholipid analogues containing an oligomerisable head group. Properties and mechanism of fusion

Ravoo

Engberts

2001

J. Chem. Soc., Perkin Trans. 2

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Membrane mimetic chemistry 2 Preparation of unilamellar lipid vesicles with oligomerised membrane leaflets 16,18 2.1 Selective hydrolysis of the -nitrostyrene group in the outer leaflet of bilayer vesicles 2.2 Photopolymerisation of the -nitrostyrene group in bilayer vesicles 2.3 Preparation of bilayer vesicles with an oligomerised inner membrane leaflet 3 Properties of vesicles formed from lipids with oligomerisable head groups 16,18,19 3.1 Differential scanning calorimetry of vesicles of oligomerised lipids 18 3.2 Lipid monolayer experiments 18 3.3 31 P-NMR spectroscopy and lipid head group mobility 18 3.4 Vesicle contents leakage and solubilisation by detergent 4 Calcium-induced fusion of vesicles formed from lipids with oligomerisable head groups 17,19 4.1 Calcium-induced fusion of vesicles of lipids with -nitrostyrene head groups 4.2 Asymmetric vesicle fusion 4.3 Fusion of oligomerised bilayer vesicles 5 Electron microscopic investigations of calcium-induced fusion of vesicles with an oligomerised inner membrane leaflet 21 5.1 Morphology and calcium-induced fusion of vesicles formed from lipid 3 5.2 Calcium-induced fusion of vesicles formed from lipid 1 6 Thermodynamics of calcium-induced vesicle fusion 17 6.1 Separating calcium ion binding, vesicle aggregation, and bilayer fusion 6.2 Isothermal titration microcalorimetry and the thermodynamics of membrane fusion 7 Fusion of Sendai virus with vesicles of oligomerisable lipids 20 7.1 Lipid mixing assays and TEM 7.2 Isothermal titration microcalorimetry 8 Conclusions 9 References 1 Membrane mimetic chemistryThe formation of phospholipid bilayer membranes that seclude and compartmentalise all eukaryotic cells is considered to be a prerequisite for the evolution of cell life.

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Photodimerisation of a styrylpyrazine amphiphile suppresses the release of glucose entrapped in its mixed vesicle with DPPC

Cited by 9 publications

References 11 publications

Light Scattering as Spectroscopic Tool for the Study of Disperse Systems Useful in Pharmaceutical Sciences

Light Scattering as Spectroscopic Tool for the Study of Disperse Systems Useful in Pharmaceutical Sciences

pH-Sensitive Breathing of Clay within the Polyelectrolyte Matrix

Vesicles formed from phospholipid analogues containing an oligomerisable head group. Properties and mechanism of fusion

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