Photodamage to human skin by suberythemal exposure to solar ultraviolet radiation can be attenuated by sunscreens: a review

Seité, Sophie; Fourtanier, Anny; Moyal, Dominique; Young, Antony R.

doi:10.1111/j.1365-2133.2010.10018.x

Cited by 115 publications

(85 citation statements)

References 81 publications

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“…To give clinical relevance to our results, we found an average BED for light skin being equivalent to 7Á3 J cm À2 and MED for skin phototype II is equivalent to 2-6 J cm À2 under the same exposure condition. 27 We also analysed UVR-induced DNA damage (CPD) using mouse monoclonal antibody H3 (Sigma, St Louis, MO, U.S.A.) and fluorescein isothiocyanate-conju- gated rabbit antimouse immunoglobulins (Dako, Glostrup, Denmark) as a second antibody on samples collected immediately after UVR exposure. Whereas for light, intermediate and tan skin, DNA lesions were detected in all epidermal layers including the basal layer and the upper dermis, they were present only in the suprabasal layers in brown and dark skin (Fig.…”

Section: Colorimetric Measurements Of Skin Samplesmentioning

confidence: 99%

Variations in skin colour and the biological consequences of ultraviolet radiation exposure

2013

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SummaryHarmful consequences of sun exposure range from sunburn, photoageing and pigmentary disorders to skin cancer. The incidence and extent of these detrimental effects are largely due to the degree of constitutive pigmentation of the skin. The latter can be objectively classified according to the individual typology angle (°ITA) based on colorimetric parameters. The physiological relevance of the ITA colorimetric classification was assessed in 3500 women living in various geographical areas. Furthermore, in order to understand the relationship between constitutive pigmentation and ultraviolet radiation (UVR) sensitivity, we worked on ex vivo human skin samples of different colour exposed to increasing UVR doses. For each sample we defined the biologically efficient dose (BED), based on the induction of sunburn cells, and analysed UVR-induced DNA damage (cyclobutane thymine dimers, CPD). We found a significant correlation between ITA and BED. We also found a correlation between ITA and DNA damage. As the epidermal basal layer also hosts melanocytes and in order to analyse the relationship between skin colour and DNA damage occurring specifically within this cell type, we performed double staining for CPD and tyrosinase-related protein (TRP) 1, a key enzyme in melanin synthesis. We found that DNA damage within melanocytes depends on ITA. Taken together our results may explain the higher risk of lighter skin types developing skin cancers, including melanoma, as well as the development of pigmentary disorders in moderately pigmented skin. They show that skin classification based on ITA is physiologically relevant (as it correlates with constitutive pigmentation) and further support the concept of a more personalized approach to photoprotection that corresponds to a particular skin colour type's sensitivity to solar UVR.What's already known about this topic?• Sun exposure sensitivity is largely dependent on the degree of skin constitutive pigmentation.What does this study add?• The individual typology angle (ITA)-based skin colour classification correlates with constitutive pigmentation and is physiologically relevant in different geographical areas.• It may help identify differential responses to ultraviolet radiation (UVR) exposure that correspond to particular skin colour type's UVR sensitivities.• It supports the concept of personalized photoprotection.Harmful consequences of sun exposure range from sunburn, photoageing and pigmentary disorders to skin cancer. The incidence and extent of these detrimental effects is largely dependent on the degree of constitutive pigmentation of the skin.1-6 Human skin colour is determined by the total quantity of melanin, the proportion between the brown-black eumelanin

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Section: Colorimetric Measurements Of Skin Samplesmentioning

confidence: 99%

Variations in skin colour and the biological consequences of ultraviolet radiation exposure

2013

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“…However, DNA damage occurs even with suberythemal doses of UV radiation 26 and the damage may persist, at least in an animal model. 27 Recent research has shown that human skin contains large numbers of evolving clones of abnormal cells that contain a high proportion of cancer-causing mutations.…”

Section: Biological Effects Of Uvb and Uvamentioning

confidence: 99%

Are current guidelines for sun protection optimal for health? Exploring the evidence

Lucas

Neale

Madronich

et al. 2018

Photochem Photobiol Sci

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Exposure of the skin to ultraviolet (UV) radiation is the main risk factor for skin cancer, and a major source of vitamin D, in many regions of the world. Sun protection messages to minimize skin cancer risks but avoid vitamin D deficiency are challenging, partly because levels of UV radiation vary by location, season, time of day, and atmospheric conditions. The UV Index provides information on levels of UV radiation and is a cornerstone of sun protection guidelines. Current guidelines from the World Health Organization are that sun protection is required only when the UV Index is 3 or greater. This advice is pragmatic rather than evidence based. The UV Index is a continuous scale; more comprehensive sun protection is required as the UV Index increases. In addition, a wide range of UVA doses is possible with a UVI of 3, from which there may be health consequences, while full sun protection when the UVI is "moderate" (between 3 and 5) may limit vitamin D production. Finally, the duration of time spent in the sun is an essential component of a public health message, in addition to the intensity of ambient UV radiation as measured by the UV Index. Together these provide the dose of UV radiation that is relevant to both skin cancer genesis and vitamin D production. Further education is required to increase the understanding of the UV Index; messages framed using the UV Index need to incorporate the importance of duration of exposure and increasing sun protection with increasing dose of UV radiation.

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“…Los efectos macroscópicos de los extractos solo son el reflejo de la acción de estos actuando a nivel celular y molecular. El estudio histopatológico de las pieles pretratadas es consistente con lo descrito anteriormente en la literatura acerca del daño inducido por las radiaciones UVB (Liou & Campbell, 1995;Seité et al 2010), ya que en los grupos "irradiados" y "placebo" ). 1: Epidermis; 2: Dermis; 3: Congested blood vessels.…”

Section: Discussionunclassified

Actividad fotoprotectora y fotorreparadora de los extractos de las angiospermas marinas, <i>Thalassia testudinum</i> Banks ex König (Hyrocharitacea) y <i>Syringodium filiforme</i> Kützing (Cymodoceaceae)

Mollineda¹,

García²,

García³

et al. 2015

Rev. Mar. Cost.

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RESUMENEstudios realizados con Thalassia testudinum y Syringodium filiforme han demostrado que estas plantas poseen un alto contenido de polifenoles y una marcada actividad antioxidante. Este estudio describe el efecto tópico de los extractos de estas plantas contra el daño agudo inducido por la radiación ultravioleta B (UVB). Las fanerógamas empleadas fueron recolectadas a 3-4 metros de profundidad en el noroeste de La Habana. Para la administración de los tratamientos se crearon cinco grupos experimentales. El efecto de los extractos fue evaluado in vivo, irradiando la piel de la región dorsal de ratones albinos con radiación UVB (dosis: 1.21x10 3 Jxcm 2 ) por seis minutos. Antes o después de la radiación UVB los animales recibieron tratamiento tópico con los extractos de ambas angiospermas a dosis de 500 µg x cm 2 de piel. Se observaron diferencias significativas (P ≤ 0.05) entre los grupos T. testudinum, S. filiforme y los "irradiados" y "placebo". Los extractos de T. testudinum y S. filiforme reducen el daño macroscópico causado por la radiación UVB en las pieles irradiadas en los modelos de tratamiento preventivo y de fotodaño. Además, mostraron un efecto protector y reparador del daño inducido por las radiaciones UVB, lo que podría estar relacionado con su actividad antioxidante.Palabras claves: Thalassia, Syringodium, radiación, fotoprotección, piel. ABSTRACTPrevious studies with the aqueous-ethanol extracts obtained from the marine angiosperms T. testudinum and S. filiforme have shown their high polyphenolic content and marked antioxidant capacity. This study describes the effects of the topical application of the aqueous-ethanol extracts of T. testudinum and S. filiforme leaves against acute UVB-induced damage. The phanerogams

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Photodamage to human skin by suberythemal exposure to solar ultraviolet radiation can be attenuated by sunscreens: a review

Cited by 115 publications

References 81 publications

Variations in skin colour and the biological consequences of ultraviolet radiation exposure

Variations in skin colour and the biological consequences of ultraviolet radiation exposure

Are current guidelines for sun protection optimal for health? Exploring the evidence

Actividad fotoprotectora y fotorreparadora de los extractos de las angiospermas marinas, <i>Thalassia testudinum</i> Banks ex König (Hyrocharitacea) y <i>Syringodium filiforme</i> Kützing (Cymodoceaceae)

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