Photocytotoxicity and Magnetic Relaxivity Responses of Dual-Porous γ-Fe2O3@meso-SiO2 Microspheres

Xuan, Shou Hu; Lee, Siu Fung; Lau, Justin Kai-Chi; Zhu, Xiaoming; Wáng, Yì Xiáng J.; Wang, Feng; Lai, Josie M.Y.; Sham, Kathy W.Y.; Lo, Pui‐Chi; Yu, Jimmy C.; Chen, Cheng; Leung, Ken Cham Fai

doi:10.1021/am300008x

Cited by 50 publications

(21 citation statements)

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“…In the present study, the mesoporous silica nanoparticles with inner pore channels of approximately 2.5 nm were used [9], [14], [15] for loading of pure CHX. By swelling the blank mesoporous nanoparticles in an ethanolic solution of pure CHX, a significant amount of over 20 weight percent of CHX was encapsulated in the nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Nanoparticle-Encapsulated Chlorhexidine against Oral Bacterial Biofilms

et al. 2014

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BackgroundChlorhexidine (CHX) is a widely used antimicrobial agent in dentistry. Herein, we report the synthesis of a novel mesoporous silica nanoparticle-encapsulated pure CHX (Nano-CHX), and its mechanical profile and antimicrobial properties against oral biofilms.Methodology/Principal FindingsThe release of CHX from the Nano-CHX was characterized by UV/visible absorption spectroscopy. The antimicrobial properties of Nano-CHX were evaluated in both planktonic and biofilm modes of representative oral pathogenic bacteria. The Nano-CHX demonstrated potent antibacterial effects on planktonic bacteria and mono-species biofilms at the concentrations of 50–200 µg/mL against Streptococcus mutans, Streptococcus sobrinus, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans and Enterococccus faecalis. Moreover, Nano-CHX effectively suppressed multi-species biofilms such as S. mutans, F. nucleatum, A. actinomycetemcomitans and Porphyromonas gingivalis up to 72 h.Conclusions/SignificanceThis pioneering study demonstrates the potent antibacterial effects of the Nano-CHX on oral biofilms, and it may be developed as a novel and promising anti-biofilm agent for clinical use.

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Section: Discussionmentioning

confidence: 99%

Nanoparticle-Encapsulated Chlorhexidine against Oral Bacterial Biofilms

et al. 2014

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“…[1][2][3][4] In the nanometer range, they are considered suitable candidates for biomedical applications, such as photodynamic therapy (PDT), magnetic resonance imaging (MRI), drug delivery, and hyperthermia. 5,6 To be successfully utilized for biomedical applications, it is essential to develop narrowsized magnetite with biocompatible surface to render SPIONs nonimmunogenic and nonantigenic, as well as to reduce their interaction with plasma proteins such as formation of "corona".…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted green synthesis of superparamagnetic nanoparticles using fruit peel extracts: surface engineering, T2 relaxometry, and photodynamic treatment potential

Bano¹,

Nazir²,

Nazir³

et al. 2016

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) have the potential to be used as multimodal imaging and cancer therapy agents due to their excellent magnetism and ability to generate reactive oxygen species when exposed to light. We report the synthesis of highly biocompatible SPIONs through a facile green approach using fruit peel extracts as the biogenic reductant. This green synthesis protocol involves the stabilization of SPIONs through coordination of different phytochemicals. The SPIONs were functionalized with polyethylene glycol (PEG)-6000 and succinic acid and were extensively characterized by X-ray diffraction analysis, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, atomic force microscopy, Rutherford backscattering spectrometry, diffused reflectance spectroscopy, fluorescence emission, Fourier-transform infrared spectroscopy, ultraviolet-visible spectroscopy, and magnetization analysis. The developed SPIONs were found to be stable, almost spherical with a size range of 17–25 nm. They exhibited excellent water dispersibility, colloidal stability, and relatively high R 2 relaxivity (225 mM −1 s −1 ). Cell viability assay data revealed that PEGylation or carboxylation appears to significantly shield the surface of the particles but does not lead to improved cytocompatibility. A highly significant increase of reactive oxygen species in light-exposed samples was found to play an important role in the photokilling of human cervical epithelial malignant carcinoma (HeLa) cells. The bio-SPIONs developed are highly favorable for various biomedical applications without risking interference from potentially toxic reagents.

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“…Recently, relatively non-cytotoxic iron oxide magnetic nanocomposites with tunable particle and pore sizes and their hollow and core/shell derivatives were introduced to successfully demonstrate a better magnetic separation method for recycling the nanomaterials from the reaction mixture using a magnet [13][14][15][16][17][18][19][20]. Different magnetic hybrid nanostructures have been successfully fabricated in spheres, wires, etc, which would be capable to covalently attach or physically encapsulate supramolecules, organic molecules, and drugs [21][22][23][24][25][26]. For covalent attachment of molecules, the process can be performed by chemical coupling reactions between molecules with functional groups and nanoparticles with reactive surface at their periphery or at the mesopores.…”

Section: Highlightmentioning

confidence: 99%

The Quest of Smart Nanomaterials for Multiple Drug Delivery

Leung¹

2017

Arch Chem Res

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HighlightRecently, the research of smart nanomaterials embedded with molecular and nano-machines has gained much attention on accounting for their prolific applications in the fields of nanotechnology, in particular for controlled drug delivery and bio-mimetics. For biomolecules and various biological systems, the functions of the sensor, processor and effector are associated with the hierarchical structures based on covalent or noncovalent bonds. Combining these functions in synthetic nanomaterials could lead to a mimic of the natural feedback systems. The realization of the proposed research idea would hopefully shed light on mimicking functional enzyme systems [1][2][3][4].For example, "smart" switchable interlocking molecules could be attached to the pore orifices of mesoporous silica nanoparticles. Subsequently, the macrocyclic component threaded on the interlocked molecule's backbone by noncovalent interactions could serve as the gate that controls access of guest molecules into and out of the nanopores of the mesoporous silica nanoparticles, to act as nanovalves [5,6]. One of the attractive features of nanovalve systems is the ability to induce controlled release (a diffusion-controlled system) of guest molecules from the nanopores using various external stimuli such as pH change [7] addition of salts, [8] redox process, [9] and light [10]. Moreover, these ON/OFF switchable molecular nanovalves process superior properties of reversibility and reusability of the materials as well as the regional and temporal control of substrate release. To facilitate practical biomedical applications in vivo, the use of non-invasive low-intensity ultrasound [11] has been routinely employed for pregnancy diagnosis, as a stimulus to trigger drug release from the drugencapsulated smart materials. On the other hand, the ability to carry hydrophobic and hydrophilic drugs to specific cancer site (targeting) is beneficial to cancer treatment with smart materials [12]. In particular, smart materials that are responsive to significant pH change between cancerous cells (pH~5) and normal cells (pH~7), are candidates for targeted therapy. Recently, relatively non-cytotoxic iron oxide magnetic nanocomposites with tunable particle and pore sizes and their hollow and core/shell derivatives were introduced to successfully demonstrate a better magnetic separation method for recycling the nanomaterials from the reaction mixture using a magnet [13][14][15][16][17][18][19][20]. Different magnetic hybrid nanostructures have been successfully fabricated in spheres, wires, etc, which would be capable to covalently attach or physically encapsulate supramolecules, organic molecules, and drugs [21][22][23][24][25][26]. For covalent attachment of molecules, the process can be performed by chemical coupling reactions between molecules with functional groups and nanoparticles with reactive surface at their periphery or at the mesopores. For physical encapsulation of molecules to the nanoparticles, porous nanoparticles with tunable pore size can be em...

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Photocytotoxicity and Magnetic Relaxivity Responses of Dual-Porous γ-Fe₂O₃@meso-SiO₂ Microspheres

Cited by 50 publications

References 61 publications

Nanoparticle-Encapsulated Chlorhexidine against Oral Bacterial Biofilms

Nanoparticle-Encapsulated Chlorhexidine against Oral Bacterial Biofilms

Microwave-assisted green synthesis of superparamagnetic nanoparticles using fruit peel extracts: surface engineering, <em>T</em><sub>2</sub> relaxometry, and photodynamic treatment potential

The Quest of Smart Nanomaterials for Multiple Drug Delivery

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