Photocytotoxic kinetically stable ruthenium(<scp>ii</scp>)-<i>N</i>,<i>N</i>-donor polypyridyl complexes of oxalate with anticancer activity against HepG2 liver cancer cells

Sayala, Juhi; Srivastava, Ekta; Kumar, Priyaranjan; Shukla, Nitin; Kumar, Ashok; Patra, Ashis K.

doi:10.1039/d3dt04058e

Dalton Trans.

2024

DOI: 10.1039/d3dt04058e

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Photocytotoxic kinetically stable ruthenium(ii)-N,N-donor polypyridyl complexes of oxalate with anticancer activity against HepG2 liver cancer cells

Juhi Sayala,

Ekta Srivastava,

Priyaranjan Kumar

et al.

Abstract: Liver cancer is one of the leading causes of death motivating scientists worldwide to synthesize novel therapeutics. Ru(II)-polypyridyl complexes are extensively studied for possible therapeutic and cellular applications due to...

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No Switching Cooperativity between Coordinated Azo Ligands on Complexes Having {M^II(phosphane-κ²P)}²⁺ (M = Pd, Pt) Scaffolds

Raïch Panisello,

Jover,

Puigjaner

et al. 2024

Inorg. Chem.

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A series of square-planar palladium and platinum compounds with cis-blocking phosphanes and terminal azobenzene ligands [M(dppp)-(azo) 2 ](OTf) 2 (azo = CN(C 6 H 4 )-N�N-(C 6 H 4 )CN (iso-cyano), CN-(C 6 H 4 )-N�N-(C 6 H 5 ) (iso-Ph)) and [{M 2 (tpbz)}(azo) 4 ](OTf) 4 (azo = CN(C 6 H 4 )-N�N-(C 6 H 5 ) (iso-Ph)) have been synthesized and fully characterized. Similarly to the uncoordinated ligands, the new coordination compounds have shown to be photochemically active with respect to their trans-to-cis isomerization process. Their cis-to-trans back spontaneous reaction have been studied as a function of solvent, temperature and pressure and the corresponding activation parameters determined in order to investigate the mechanism of these transformations. The results obtained are indicative of the operation of a rotational mechanism with no cooperativity between the azo ligands attached to the same metal. Density functional theory calculations have been carried out in order to estimate the relative energies of the different photoisomers for the theoretical interpretation of the experimental data.

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No Switching Cooperativity between Coordinated Azo Ligands on Complexes Having {M^II(phosphane-κ²P)}²⁺ (M = Pd, Pt) Scaffolds

Raïch Panisello,

Jover,

Puigjaner

et al. 2024

Inorg. Chem.

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show abstract

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Photocytotoxic kinetically stable ruthenium(ii)-N,N-donor polypyridyl complexes of oxalate with anticancer activity against HepG2 liver cancer cells

Abstract: Liver cancer is one of the leading causes of death motivating scientists worldwide to synthesize novel therapeutics. Ru(II)-polypyridyl complexes are extensively studied for possible therapeutic and cellular applications due to...

Cited by 1 publication

References 56 publications

No Switching Cooperativity between Coordinated Azo Ligands on Complexes Having {M^II(phosphane-κ²P)}²⁺ (M = Pd, Pt) Scaffolds

No Switching Cooperativity between Coordinated Azo Ligands on Complexes Having {M^II(phosphane-κ²P)}²⁺ (M = Pd, Pt) Scaffolds

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Photocytotoxic kinetically stable ruthenium(ii)-N,N-donor polypyridyl complexes of oxalate with anticancer activity against HepG2 liver cancer cells

Abstract: Liver cancer is one of the leading causes of death motivating scientists worldwide to synthesize novel therapeutics. Ru(II)-polypyridyl complexes are extensively studied for possible therapeutic and cellular applications due to...

Cited by 1 publication

References 56 publications

No Switching Cooperativity between Coordinated Azo Ligands on Complexes Having {MII(phosphane-κ2P)}2+ (M = Pd, Pt) Scaffolds

No Switching Cooperativity between Coordinated Azo Ligands on Complexes Having {MII(phosphane-κ2P)}2+ (M = Pd, Pt) Scaffolds

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Product

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No Switching Cooperativity between Coordinated Azo Ligands on Complexes Having {M^II(phosphane-κ²P)}²⁺ (M = Pd, Pt) Scaffolds

No Switching Cooperativity between Coordinated Azo Ligands on Complexes Having {M^II(phosphane-κ²P)}²⁺ (M = Pd, Pt) Scaffolds