Photocrosslinkable nanocomposite ink for printing strong, biodegradable and bioactive bone graft

Yang, Yaning; Zhang, Qiang; Xu, Tianpeng; Zhang, Hongyu; Zhang, Ming; Li, Lu; Hao, Yuefeng; Fuh, Jerry Ying Hsi; Zhao, Xin

doi:10.1016/j.biomaterials.2020.120378

Cited by 77 publications

(74 citation statements)

References 60 publications

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“…[6] Composite grafts were regarded as potential options to strengthen mechanical properties of polymers. [31] Bioglass, [32,33] calcium phosphate, [9] and hydroxyapatite (HA) [34] are added to enhance mechanical stability of grafts. For instance, composites of poly(ethylene glycol)-based hydrogels and amorphous calcium phosphate significantly enhanced stiffness of grafts.…”

Section: Materials Considerations For Biocompatibility Mechanical Strength and Osteogenesismentioning

confidence: 99%

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Xie

Liang

et al. 2021

Adv Healthcare Materials

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The failure to repair critical-sized bone defects often leads to incomplete regeneration or fracture non-union. Tissue-engineered grafts have been recognized as an alternative strategy for bone regeneration due to their potential to repair defects. To design a successful tissue-engineered graft requires the understanding of physicochemical optimization to mimic the composition and structure of native bone, as well as the biological strategies of mimicking the key biological elements during bone regeneration process. This review provides an overview of engineered graft-based strategies focusing on physicochemical properties of materials and graft structure optimization from macroscale to nanoscale to further boost bone regeneration, and it summarizes biological strategies which mainly focus on growth factors following bone regeneration pattern and stem cell-based strategies for more efficient repair. Finally, it discusses the current limitations of existing strategies upon bone repair and highlights a promising strategy for rapid bone regeneration.

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Section: Materials Considerations For Biocompatibility Mechanical Strength and Osteogenesismentioning

confidence: 99%

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Xie

Liang

et al. 2021

Adv Healthcare Materials

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“…In vitro: cell viability, proliferation, and morphology of rMSCs In vivo: bone regeneration of rabbit femoral condyle defects [87] (Continued) [88] Silk fibroin/bioactive glass In vitro: cell attachment, viability, proliferation and osteogenic activities of hBMSCs In vivo: heterotopic bone formation [89] PCL/decellularized porcine bone…”

Section: Ha/carboxymethyl Chitosan/polydopaminementioning

confidence: 99%

Section: Metallic Scaffoldsmentioning

confidence: 99%

“…The bone grafts printed with this nanocomposite ink showed enhanced osteoconductivity both in vitro and in vivo (Figure 3). [87] In addition to HA, decellularized bone and other bioactive ceramics, such as -TCP and bioactive glass, have been investigated to optimize the mechanical property and osteogenic capability of printed scaffolds. As one of the most commonly used CaP ceramics, -TCP has excellent osteoconductivity and biocompatibility.…”

Section: Hybrid Scaffoldsmentioning

confidence: 99%

mentioning

confidence: 99%

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Multi‐Dimensional Printing for Bone Tissue Engineering

Wang

Zhou

et al. 2021

Adv Healthcare Materials

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The development of 3D printing has significantly advanced the field of bone tissue engineering by enabling the fabrication of scaffolds that faithfully recapitulate desired mechanical properties and architectures. In addition, computer-based manufacturing relying on patient-derived medical images permits the fabrication of customized modules in a patient-specific manner. In addition to conventional 3D fabrication, progress in materials engineering has led to the development of 4D printing, allowing time-sensitive interventions such as programed therapeutics delivery and modulable mechanical features. Therapeutic interventions established via multi-dimensional engineering are expected to enhance the development of personalized treatment in various fields, including bone tissue regeneration. Here, recent studies utilizing 3D printed systems for bone tissue regeneration are summarized and advances in 4D printed systems are highlighted. Challenges and perspectives for the future development of multi-dimensional printed systems toward personalized bone regeneration are also discussed.

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Sculpting Bio‐Inspired Surface Textures: An Adhesive Janus Periosteum

Yang

Bei

et al. 2021

Adv Funct Materials

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Existing artificial periostea faces difficulty in supporting the entire bone repair cycle due to the absence of adhesion-centric design and effective cell manipulation, leading to poor inhibition of soft tissue infiltration and induction of osteogenesis and angiogenesis. Here, a Janus periosteum with interior surface adhesion and exterior anatomical patterns to mimic the structure and function of natural periosteum is presented. Photocrosslinkable polymers are employed to replicate the exterior anisotropic surface structured microgrooves for cell fate manipulation and assemble gecko-inspired fibrillar setae arrays for interior surface adhesion. To further bolster its underwater adhesiveness, mussel-inspired poly (dopamine methacrylamide-co-hydroxyethyl methacrylate) (PDMH) is coated onto the periosteum surfaces. This periosteum presents adhesiveness with strong shear and normal adhesion in both dry and wet conditions due to the coordinated interactions of micro setae arrays and PDMH coating; it also boasts effective cell modulation for enhanced synchronous osteogenesis and angiogenesis, without the aid of growth factors. Moreover, the Janus periosteum is found to enhance bone regeneration in vivo with increased new bone formation and neovascularization. It is envisioned that this Janus periosteum will be able to streamline bone fracture surgical repair as a rapidly adhesive, low-maintenance yet robust bandage to significantly cut down the healing phase.

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Photocrosslinkable nanocomposite ink for printing strong, biodegradable and bioactive bone graft

Cited by 77 publications

References 60 publications

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Multi‐Dimensional Printing for Bone Tissue Engineering

Sculpting Bio‐Inspired Surface Textures: An Adhesive Janus Periosteum

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