Photocontrolled Targeted Drug Delivery: Photocaged Biologically Active Folic Acid as a Light‐Responsive Tumor‐Targeting Molecule

Fan, Nien-Chu; Cheng, Fong‐Yu; Ho, Ja‐an Annie; Yeh, Chen-Sheng

doi:10.1002/ange.201203339

Cited by 46 publications

(34 citation statements)

References 32 publications

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“…However, the expression of receptors responding to these makers varies for different cancer cells and even happens in pluripotent or young healthy cells [170]. For instance, a moderate-to-low frequency of FR expression is found in lung (66 %, non-small cell), endometrium (64 %), thyroid (48 %), breast (29 %), and lung (25 %, small cell) carcinoma, and the expression also occurs in normal kidney cells [171]. In this work, o-nitrobenzyl-caged FA was attached to the surface of silica-coated NaYF 4 :Yb/Tm UCNPs via covalent conjugation to achieve NIR lighttriggered active targeting.…”

Section: Caging Groupmentioning

confidence: 97%

Upconversion Nanoparticles for Light-Activated Therapy

Zhang¹

2014

Photon Upconversion Nanomaterials

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Light-activated therapy (LAT) has attracted enormous attention over the past decades because light enables noninvasive activation or release of various therapeutic compounds, such as photosensitizers, chemotherapeutic drugs, proteins, and genes with high spatial and temporal resolution. However, most currently used photosensitive compounds in LAT are sensitive to ultraviolet (UV) or visible light which suffers from some limitations such as low tissue penetration and photodamage to living organisms. Upconversion nanoparticles (UCNPs) that can convert near-infrared (NIR) light to visible/UV light have been proven to be effective for LAT in vivo in recent years, owing to the high tissue penetration and minimal photocytotoxicity of NIR light. Furthermore, hydrophilic UCNPs with targeting moieties can transport hydrophobic drugs in biological media and achieve active targeting, thus enhancing the therapeutic efficacy. In this chapter, we review the recent advances in the field of UCNP-based LAT with focus on photodynamic therapy (PDT) and NIR light-triggered release and uncaging.Keywords Light-activated therapy Á Upconversion nanoparticles Á Near-infrared excitation Á Photodynamic therapy Á Photosensitizer Á Light-triggered drug release Á Uncaging IntroductionThe past decades have seen considerable interest and progress in light-activated therapy (LAT), including photodynamic therapy (PDT), chemotherapy, gene therapy, and photothermal therapy (PTT) as light is noninvasive and controllable both spatially and temporally compared to other stimuli such as temperature, pH, ultrasound, and applied magnetic or electric fields [1,2]. Owing to these Zhenzhen Guo and Fan Zhang contributed together to this chapter.© Springer-Verlag Berlin Heidelberg 2015 F. Zhang, Photon Upconversion Nanomaterials, Nanostructure Science and Technology, DOI 10.1007/978-3-662-45597-5_9 285 advantages, this effective therapeutic approach is beneficial to control drug dosing in terms of quantity, location, and time, hence maximizing therapeutic effect while minimizing side effects [3]. However, the excitation of most commonly used photosensitizers for PDT and photoactive molecules for the release of chemotherapeutic drugs and genes relies on high-energy ultraviolet (UV) or visible light irradiation [4,5]. The tissue penetration depth of UV-visible light is shallow because of the scattering and absorption by tissue chromophores [6]. What is worse, the heterocyclic bases of DNA are major UV-absorbing chromophores in the skin. The absorption leads to damage of the DNA, which may result in the generation of tumors [7]. These limitations would greatly hamper their applications in vivo. Compared to UV and visible light, near-infrared (NIR) light has a larger penetration depth, lower levels of the auto-fluorescence , and photodamage effect [8] and is thus better suited for biomedical applications. Therefore, another component that is capable of converting NIR excitation into UV or visible emission should be introduced into current LAT systems in o...

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Section: Caging Groupmentioning

confidence: 97%

Upconversion Nanoparticles for Light-Activated Therapy

Zhang¹

2014

Photon Upconversion Nanomaterials

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“…[78] Phototargeting has been employed with other ligands including cell-penetrating peptides [79] and folic acid [80,81]. The relatively poor tissue penetration limits the use of UV to organs that can be directly illuminated, such as the skin, or to targets that can be reached by endoscopic techniques.…”

Section: Uv-induced Phototargetingmentioning

confidence: 99%

Ultraviolet light-mediated drug delivery: Principles, applications, and challenges

Barhoumi

Liu²,

Kohane

2015

Journal of Controlled Release

139

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“…Photo-responsive targeted therapy Light can be used not only to induce payload release but also to determine the timing and specific location at which AuNMs will bind to the targeted tissue, to improve efficacy and decrease systemic toxicity. For example, Yeh and co-workers also established a smart photoactivated AuNMs drug delivery system that, upon UV light activation, can selectively target tumor cells and release an anti-cancer drug (Taxol) [99]. NIR irradiation has also been used to recover the function of surface-bound ligands blocked by steric hindrance on alloy (silica-gold) nanoshells [100].…”

Section: Ionizing Radiations As External Physical Stimulimentioning

confidence: 99%

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Movia

Benhaddada

Spadavecchia

et al. 2020

Precision Nanomedicine

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Graphical abstract KeywordsGold nanoparticle 1 ; external stimuli; physical stimuli; physically triggered nanomedicine. Quote this article as: Movia D, Benhaddada M, Jolanda Spadavecchia J, Prina-Mello A, Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies, Precis. Nanomed. 2020 April;3(2):495-524, https://doi. AbstractNanomedicine aims at enhancing treatment efficiency and/or improving diagnostic sensitivity by better controlling several critical parameters, such as tissue targeting and off-target toxicity. More recently, advanced nanomedicine products have been developed to achieve spatially and temporally controlled therapy and diagnosis. This review focuses on gold nanomaterials (AuNMs) and alloy/hybrid AuNMs that can be used in stimuli-responsive strategies for therapeutic and diagnostic applications. Endogenous and/or exogenous stimuli can be used as a trigger for such systems. Herein, we focus on those activated by exogenous stimuli. Our review starts from one specific externally activated product, Aurolase®, which recently underwent clinical studies. Further we continue describing a specific physically triggered category, for which the exogeneous stimulus applied induces a structural transformation or modification that is essential for their therapeutic and/or diagnostic action. Gold nanomaterials are grouped both by the nature of the function they exert (therapeutic or diagnostic) and the stimuli class.

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Photocontrolled Targeted Drug Delivery: Photocaged Biologically Active Folic Acid as a Light‐Responsive Tumor‐Targeting Molecule

Cited by 46 publications

References 32 publications

Upconversion Nanoparticles for Light-Activated Therapy

Upconversion Nanoparticles for Light-Activated Therapy

Ultraviolet light-mediated drug delivery: Principles, applications, and challenges

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

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