Photocontrolled Reversible Amyloid Fibril Formation of Parathyroid Hormone-Derived Peptides
André Paschold,
Moritz Schäffler,
Xincheng Miao
et al.
Abstract:Peptide fibrillization is crucial in biological processes such as amyloid-related diseases and hormone storage, involving complex transitions between folded, unfolded, and aggregated states. We here employ light to induce reversible transitions between aggregated and nonaggregated states of a peptide, linked to the parathyroid hormone (PTH). The artificial light-switch 3-{[(4-aminomethyl)phenyl]diazenyl}benzoic acid (AMPB) is embedded into a segment of PTH, the peptide PTH 25−37 , to control aggregation, revea… Show more
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