Photocontrolled release using one-photon absorption of visible or NIR light

Olejniczak, Jason; Carling, Carl-Johan; Almutairi, Adah

doi:10.1016/j.jconrel.2015.09.030

Cited by 123 publications

(114 citation statements)

References 139 publications

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“…Thus, the protected and inactive molecules/compounds, which have high activity when free, become unprotected and uncaged leading to their activation, followed by their delivery and release at the desired biological site such as via binding to cell receptors or specific intracellular release (Figure 3a). 32,35,53,55,56 A wide-variety of photo-uncaging compounds have been reported based on o -nitrobenzyl, o -nitro-phenethyl, indoline, quinoline, amino-coumarin, perylene, nitrophenyl, nitrophenyl-propyloxy compounds, ruthenium photocages, nitrodibenzofuran (NDBF), boron-dipyrromethene derivatives, and so forth. 35,53,55–58 Nanocarriers including gold (Au) NPs, 59 micelles, 60 liposomes, 61 and peptide-based nanocarriers 35 have been reported to demonstrate photocaging/uncaging behavior.…”

Section: Miscellaneous Phototriggered Drug Release Mechanismsmentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, and so forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to specific stimuli in their environment represent a growing field. Nanoplatforms that can be activated by an external application of light can be used for a wide variety of photoactivated therapies, especially light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so forth. In addition, light activation has potential in photodynamic therapy, photothermal therapy, radiotherapy, protected delivery of bioactive moieties, anticancer drug delivery systems, and theranostics (i.e., real-time monitoring and tracking combined with a therapeutic action to different diseases sites and organs). Combinations of these approaches can lead to enhanced and synergistic therapies, employing light as a trigger or for activation. Nonlinear light absorption mechanisms such as two-photon absorption and photon upconversion have been employed in the design of light-responsive DDSs. The integration of a light stimulus into dual/multiresponsive nanocarriers can provide spatiotemporal controlled delivery and release of therapeutic agents, targeted and controlled nanosystems, combined delivery of two or more agents, their on-demand release under specific conditions, and so forth. Overall, light-activated nanomedicines and DDSs are expected to provide more effective therapies against serious diseases such as cancers, inflammation, infections, and cardiovascular disease with reduced side effects and will open new doors toward the treatment of patients worldwide.

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Section: Miscellaneous Phototriggered Drug Release Mechanismsmentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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“…Recently, near-IR photodecaging strategies have been described based on cyanine 19, BODIPY, 20 and phthalocyanine 21 dyes. 22 A current challenge for red- and near-IR photodecaging strategies lies is the need to improve the kinetics of photorelease.…”

Section: Introductionmentioning

confidence: 99%

Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation

et al. 2016

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Rapid bioorthogonal reactivity can be induced by controllable, catalytic stimuli using air as the oxidant. Methylene blue (4 μM) irradiated with red light (660 nm) catalyzes the rapid oxidation of a dihydrotetrazine to a tetrazine thereby turning on reactivity toward trans-cyclooctene dienophiles. Alternately, the aerial oxidation of dihydrotetrazines can be efficiently catalyzed by nanomolar levels of horseradish peroxidase under peroxide-free conditions. Selection of dihydrotetrazine/tetrazine pairs of sufficient kinetic stability in aerobic aqueous solutions is key to the success of these approaches. In this work, polymer fibers carrying latent dihydrotetrazines were catalytically activated and covalently modified by trans-cyclooctene conjugates of small molecules, peptides and proteins. In addition to visualization with fluorophores, fibers conjugated to a cell adhesive peptide exhibited a dramatically increased ability to mediate contact guidance of cells.

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“…20 Therefore, systems able to respond to visible (Vis) light rather than to UV offer a less harmful alternative. 21 Vis light exhibits a more effective tissue penetrability (attenuation down to 1 % occurs up to 1.2 µm at 800 µm), which is ideal for medical applications. Besides, Vis light has a more innocuous nature due to a smaller energetic content.…”

Section: Introductionmentioning

confidence: 99%