Photocontrolled bromine–iodine transformation reversible-deactivation radical polymerization: facile synthesis of star copolymers and unimolecular micelles

Abstract

The ideal particle size and high stability of unimolecular micelles (UIM) formed from star copolymers make them less susceptible to microenvironment changes in vivo, giving them unique advantages in many...

GSH-triggered disintegrable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific chemotherapy

“…2a). 12,21 The inset in Fig. 2a reveals HBPP-DOX-3 micelles in PBS with a strong Tyndall effect, also confirming their excellent dispersibility.…”

“…2c), also indicating the formation of unimolecular micelles with superior stability. 12,21 The supernatant of the GSH-triggered disintegrable unimolecular micelles after treatment with pH 7.4 PBS + 10% BSA for 5 days was colorless and showed no absorbance of DOX (Fig. S12†).…”

Unimolecular micelles from star-shaped block polymers by photocontrolled BIT-RDRP for PTT/PDT synergistic therapy

“…42 A porphyrin-based initiator was also previously designed to systematically explore its regulated photocontrolled polymerization in our group, and a series of porphyrin-based star block polymers with controllable distribution were conveniently yet efficiently prepared. 43 Ketocyanine, a photothermal conversion dye with strong near-infrared (NIR) absorption, 44 can efficiently convert the absorbed light into heat under the irradiation of light at about 810 nm, which has been applied in various fields such as optical devices, 45 infrared imaging, 46–48 and photothermal therapy. 49,50 Employing organic photosensitizer is beneficial to overcome the defects of inorganic nanomaterials, which are currently the mainstream materials for optical therapeutic applications, such as poor biocompatibility and metabolism difficulties in vivo .…”

Synthesis of micrometer-sized poly(vinyl acetate) particles through microsuspension iodine transfer polymerization: effect of iodine species in a water medium

“…In recent decades, reversible-deactivation radical polymerization (RDRP) has attracted increasing research attention for the fabrication of macromolecular architectures based on welldefined polymers with a narrow molecular weight distribution, such as block, graft, and star polymers. [1][2][3] Furthermore, these polymers having a designed structure can deliver special functionalities. [4][5][6][7] Among the RDRP techniques, iodine transfer polymerization (ITP), which relies on a reversible activation-deactivation process to achieve the growth of polymer chains with low dispersity index, [8][9][10] is one of the most employed methods and is applicable to a variety of monomers.…”