Photochemistry of 2‐Nitrobenzyl Enol Ethers: Oxidative C=C Bond Scission.

Yong, Promise K.; Banerjee, Ashis G.

doi:10.1002/chin.200544069

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Water was deionized through a Milli-Q apparatus (Millipore) with a resistivity of 18.2 MΩ•cm. 1-((Chloromethoxy)methyl)-2-nitrobenzene (Scheme 2), 54 poly-(ethylene oxide) (PEO)-based macroinitiator (PEG-Br), 55 and PEO 45 -b-PNBM 21 (PNO) diblock copolymer were synthesized according to reported procedures.…”

Section: ■ Introductionmentioning

confidence: 99%

Photoresponsive Micelles Enabling Codelivery of Nitric Oxide and Formaldehyde for Combinatorial Antibacterial Applications

Duan

Zhang

et al. 2021

Biomacromolecules

View full text Add to dashboard Cite

It is of particular interest to develop new antibacterial agents with low risk of drug resistance development and low toxicity toward mammalian cells to combat pathogen infections. Although gaseous signaling molecules (GSMs) such as nitric oxide (NO) and formaldehyde (FA) have broad-spectrum antibacterial performance and the low propensity of drug resistance development, many previous studies heavily focused on nanocarriers capable of delivering only one GSM. Herein, we developed a micellar nanoparticle platform that can simultaneously deliver NO and FA under visible light irradiation. An amphiphilic diblock copolymer of poly(ethylene oxide)-b-poly(4-((2-nitro-5-(((2-nitrobenzyl)oxy)methoxy)benzyl)(nitroso)amino)benzyl methacrylate) (PEO-b-PNNBM) was successfully synthesized through atom transfer radical polymerization (ATRP). The resulting diblock copolymer self-assembled into micellar nanoparticles without premature NO and FA leakage, whereas they underwent phototriggered disassembly with the corelease of NO and FA. We showed that the NO- and FA-releasing micellar nanoparticles exhibited a combinatorial antibacterial performance, efficiently killing both Gram-negative (e.g., Escherichia coli) and Gram-positive (e.g., Staphylococcus aureus) bacteria with low toxicity to mammalian cells and low hemolytic property. This work provides new insights into the development of GSM-based antibacterial agents.

show abstract

Section: ■ Introductionmentioning

confidence: 99%