Photochemical synthesis and biological activity of 6-cis-styrylpurine.

Abstract

In the course of studies on the structure-activity relationships of 6-substituted purines,^both 6-trans-(l) and 6-cw-styrylpurine (2) were required to investigate the steric effect of the 6-substituents on cytokinin activity. The synthesis and cytokinin activity of 1 have already been

Synthesis of 6-substituted purin-2-ones with potential cytokinin activity

“…The latter compound is isomerised to the (Z )-isomer under photochemical conditions. 17 The evaluation of the cytokinin activity of the 6-substituted 2-oxopurines 14 was based on their ability to stimulate radish cotyledon growth and the results are given in Table 4. The seeds were treated with 10 µM solutions of the purines and the growth effects were measured as the increase in cotyledon weight after 72 h compared to a control sample.…”

“…The more polar fraction yielded the dialkyl purine 11a (164 mg, 32%) as a yellow oil. (19), 527 (39), 441 (29), 280 (12), 268 (17), 75 (30) and 73 (100).…”

The sunny side of chemistry: green synthesis by solar light

“…15 6-(Z)-Styrylpurine was likewise prepared by photoisomerization of the E isomer. 62 3-Aryl-2-quinolinones are a class of compounds that find use in the treatment of osteoporosis and can inhibit the migration of tumor cells. A straightforward synthesis of such compounds involved sunlight-induced isomerization of (E)-2-amino-a-phenylcinnamic acids (e.g.…”

Preparation and structure-activity relationships of 4-substituted amino-2-methylpyrido[3,4-d]pyrimidines as cytokinin analogs

“…Amaranthus Betacyanin Bioassay. According to the reported method (Biddington and Thomas, 1973), derooted seedlings grown for 60 h at 28 °C in the dark were incubated in a solution containing the sample and tyrosine in a phosphate buffer (pH 6.3) for 20-24 h under the conditions reported previously (Koyama et al, 1985).…”