Photochemical formation of mutagenic compounds from alkenes and ozone or nitrogen dioxide

Victorin, Katarina; Ståhlberg, Margareta

doi:10.1002/em.2850110109

Cited by 16 publications

(1 citation statement)

References 22 publications

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“…cumene hydroperoxide, CP) which are uptaken by biota through dry or wet deposition, even at distant points from the emission source (Tice and Brevard, 1998 and references therein). Cumene hydroperoxide may enter the environment from industrial discharges and spills, and also as a by-product of fuel oil slicks exposed to UV light (Callen and Larson, 1978;Victorin and Stahlberg, 1988). This substance is cytotoxic, genotoxic and mutagenic, inducing DNA damage and mutations in prokaryote and eukaryote systems.…”

Section: Introductionmentioning

confidence: 99%

The organic air pollutant cumene hydroperoxide interferes with NO antioxidant role in rehydrating lichen

Catalá

Gasulla

García‐Breijo

et al. 2013

Environmental Pollution

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t r a c tOrganic pollutants effects on lichens have not been addressed. Rehydration is critical for lichens, a burst of free radicals involving NO occurs. Repeated dehydrations with organic pollutants could increase oxidative damage. Our aim is to learn the effects of cumene hydroperoxide (CP) during lichen rehydration using Ramalina farinacea (L.) Ach., its photobiont Trebouxia spp. and Asterochloris erici. Confocal imaging shows intracellular ROS and NO production within myco and phycobionts, being the chloroplast the main source of free radicals. CP increases ROS, NO and lipid peroxidation and reduces chlorophyll autofluorescence, although photosynthesis remains unaffected. Concomitant NO inhibition provokes a generalized increase of ROS and a decrease in photosynthesis. Our results suggest that CP induces a compensatory hormetic response in Ramalina farinacea that could reduce the lichen's antioxidant resources after repeated desiccation-rehydration cycles. NO is important in the protection from CP.

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Section: Introductionmentioning

confidence: 99%

The organic air pollutant cumene hydroperoxide interferes with NO antioxidant role in rehydrating lichen

Catalá

Gasulla

García‐Breijo

et al. 2013

Environmental Pollution

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A method for studying the mutagenicity of some gaseous compounds in salmonella typhimurium

Victorin¹,

Ståhlberg²

1988

Environ and Mol Mutagen

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A dynamic flow-through exposure system was designed for mutagenicity studies of gaseous compounds in Salmonella. Salmonella typhimurium strain TA100 was the primary tester strain. The dose ranges were 0.5-20% of vinyl chloride, ethene, propene, and 1,3-butadiene, 1-200 ppm of ethylene oxide, 0.5-20 ppm of nitrogen dioxide, and 0.1-3.5 ppm of ozone. The gas flow rate was 250, 500, or 1,000 ml/min, and the exposure time was 6 or 7 hours. Of the tested gases, vinyl chloride, ethylene oxide, and nitrogen dioxide were mutagenic. Ethene, propene, and 1,3-butadiene were not mutagenic in this system. Ozone is bacteriotoxic, and no mutagenic effect could be demonstrated in the nontoxic dose range. The exposure system was considered suitable for studies on gaseous chemicals.

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Comparison of mutagenic activities of several peroxyacyl nitrates

Kleindienst

Shepson

Smith

et al. 1990

Environ and Mol Mutagen

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Salmonella typhimurium, strain TA100 was exposed to a series of peroxyacyl nitrates including peroxyacetyl nitrate (PAN), peroxypropionyl nitrate (PPN), peroxybutyryl nitrate (PBN), peroxybenzoyl nitrate (PBzN), and chloroperoxyacetyl nitrate (CPAN). Gas-phase concentrations for the individual exposures were in the high part per billion by volume ppbv range. The dose was determined from the deposition rate and measured from the net decrease of the test compound in the exposure chamber and the exposure time. The mutagenic activity for each compound determined from the dose-response relationship gave values ranging from 250 (PBN) to 6,500 (PBzN) revertants/mumols. The mutagenic activity for CPAN could not be determined, due to an interference from chloroacetaldehyde. The difficulties of quantifying the actual gas-phase chemical dose the bacteria are exposed to in this variant of the Ames test are delineated.

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Photochemical formation of mutagenic compounds from alkenes and ozone or nitrogen dioxide

Cited by 16 publications

References 22 publications

The organic air pollutant cumene hydroperoxide interferes with NO antioxidant role in rehydrating lichen

The organic air pollutant cumene hydroperoxide interferes with NO antioxidant role in rehydrating lichen

A method for studying the mutagenicity of some gaseous compounds in salmonella typhimurium

Comparison of mutagenic activities of several peroxyacyl nitrates

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