Photochemical effect of silver nanoparticles on flesh fly larval biological system

Ali, Musab A. M.; Ramadan, Marwa A; Ghazawy, N.A.; Afify, A. M.; Mousa, Shaker A.

doi:10.1016/j.acthis.2022.151871

Cited by 10 publications

(7 citation statements)

References 50 publications

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“…In Fig. 1 a, the absorption peak of Cis is at about 302 nm, hence Ag NPs, in a previous researches has a sharp absorption peak around 400 nm [ 35 – 37 ] the absorption curve of Co@Ag, shows a sharp peak at 410 nm which indicates the formation of Ag shell on the surface of Co nanoparticle core, upon Cis addition on CoAg core shell, broadening and slight red shift from 410 to 425 nm for the CoAg@Cis nanohybrid which indicate successful conjugation of Cis to CoAg. In (Fig.…”

Section: Resultsmentioning

confidence: 97%

“…controlled release, drug targeting, and much higher bioavailability of medications are all features of nanodrug delivery systems which greatly overcome the weaknesses of traditional drug delivery [ 30 – 34 ]. According to earlier research, poly-nano-complexes and anticancer medications can boost the anticancer drug accumulation in tumor cells for a more effective treatment outcome [ 35 – 37 ]. AgNPs exhibit a synergistic effect and a cytotoxic effect on cell viability [ 13 ], which play a key part in the antitumor action.…”

Section: Introductionmentioning

confidence: 99%

“…AgNPs help collect and deliver medications into cancer cells, and they also prevent cancer metabolism and tumor growth. According to earlier research, AgNPs can cause cell death both in vivo and in vitro by an apoptotic mechanism that is driven by reactive oxygen species (ROS) [ 35 , 38 – 40 ]. Here, we investigate the formation of a novel biocompatible nanodrug by combining CoAg and Cis in order to increase the therapeutic index on MCF7 and HCT Cell Lines.…”

Section: Introductionmentioning

confidence: 99%

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Reducing the effective dose of cisplatin using cobalt modified silver nano-hybrid as a carriers on MCF7 and HCT cell models

Faid,

Ramadan

2024

BMC Chemistry

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Cancer is a deadly illness with a convoluted pathogenesis. The most prevalent restrictions that frequently result in treatment failure for cancer chemotherapy include lack of selectivity, cytotoxicity, and multidrug resistance. Thus, considerable efforts have been focused in recent years on the establishment of a modernistic sector termed nano-oncology, which offers the option of employing nanoparticles (NPs) with the objective of detecting, targeting, and treating malignant disorders. NPs offer a focused approach compared to conventional anticancer methods, preventing negative side effects. In the present work, a successful synthetic process was used to create magnetic cobalt cores with an AgNPs shell to form bimetallic nanocomposites CoAg, then functionalized with Cis forming novel CoAg@Cis nanohybrid. The morphology and optical properties were determined by TEM, DLS, FTIRs and UV–vis spectroscopy, furthermore, anticancer effect of CoAg and CoAg@Cis nanohybrids were estimated using MTT assay on MCF7 and HCT cell lines. Our results showed that Co@Ag core shell is about 15 nm were formed with dark CoNPs core and AgNPs shell with less darkness than the core, moreover, CoAg@Cis has diameter about 25 nm which are bigger in size than Co@Ag core shell demonstrating the loading of Cis. It was observed that Cis, CoAg and CoAg@Cis induced a decline in cell survival and peaked at around 65%, 73%and 66% on MCF7 and 80%, 76%and 78% on HCT at 100 µg/ml respectively. Compared to Cis alone, CoAg and CoAg@Cis caused a significant decrease in cell viability. These findings suggest that the synthesized CoAg can be used as a powerful anticancer drug carrier. Graphical Abstract

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reducing the effective dose of cisplatin using cobalt modified silver nano-hybrid as a carriers on MCF7 and HCT cell models

Faid,

Ramadan

2024

BMC Chemistry

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“…In the last 5 years, more than 600 studies outlining the toxicity of NPs towards various vector-insects have been published. These NPs including gold, silver, titanium oxide, semiconductors, and silica-based nanomaterials have been tested against a wide range of vectors, covering mosquito, lice, and fly [ 16 , 51 ]. Among all, the large majority of the researchers focused on mosquito vectors due to their huge ecological and physiological plasticity [ 52 ].…”

Section: Application Of Nps In Vector-insectsmentioning

confidence: 99%

Nanoparticles: A Potential and Effective Method to Control Insect-Borne Diseases

Nie,

Li,

Xie

et al. 2023

Bioinorganic Chemistry and Applications

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Insects act as vectors to carry a wide range of bacteria and viruses that can cause multiple vector-borne diseases in humans. Diseases such as dengue fever, epidemic encephalitis B, and epidemic typhus, which pose serious risks to humans, can be transmitted by insects. Due to the absence of effective vaccines for most arbovirus, insect control was the main strategy for vector-borne diseases control. However, the rise of drug resistance in the vectors brings a great challenge to the prevention and control of vector-borne diseases. Therefore, finding an eco-friendly method for vector control is essential to combat vector-borne diseases. Nanomaterials with the ability to resist insects and deliver drugs offer new opportunities to increase agent efficacy compared with traditional agents, and the application of nanoagents has expanded the field of vector-borne disease control. Up to now, the reviews of nanomaterials mainly focus on biomedicines, and the control of insect-borne diseases has always been a neglected field. In this study, we analyzed 425 works of the literature about different nanoparticles applied on vectors in PubMed around keywords, such as“nanoparticles against insect,” “NPs against insect,” and “metal nanoparticles against insect.” Through these articles, we focus on the application and development of nanoparticles (NPs) for vector control, discussing the lethal mechanism of NPs to vectors, which can explore the prospect of applying nanotechnology in the prevention and control of vectors.

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“…Numerous methods were developed to detect DNA strand damage (Afify 2017; Afify and Negm 2018; Tice et al 2000). Comet assay detects DNA strand breaks by estimating the DNA movement from the nuclear DNA (Afify et al 2019; Ali et al 2022; Singh et al 1988; Collins et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Estimating the Impact of Gamma Radiation on Biochemical Aspects and DNA Damage by Comet Assay in Galleria mellonella Male

Afify,

Ali,

Sayed

2024

Entomological News

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Photochemical effect of silver nanoparticles on flesh fly larval biological system

Cited by 10 publications

References 50 publications

Reducing the effective dose of cisplatin using cobalt modified silver nano-hybrid as a carriers on MCF7 and HCT cell models

Reducing the effective dose of cisplatin using cobalt modified silver nano-hybrid as a carriers on MCF7 and HCT cell models

Nanoparticles: A Potential and Effective Method to Control Insect-Borne Diseases

Estimating the Impact of Gamma Radiation on Biochemical Aspects and DNA Damage by Comet Assay in Galleria mellonella Male

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