Photochemical and Pharmacokinetic Characterization of Orally Administered Chemicals to Evaluate Phototoxic Risk

Iyama, Yosuke; Sato, Hideyuki; Seto, Yoshiki; Onoue, Satomi

doi:10.1016/j.xphs.2018.10.013

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…Bars represented AUC measured during the 3 min of application of 8-MOP in combination with UV illumination at 330 nm. The statistical analysis was carried out with one-way ANOVA for independent samples, followed by the Tukey post-hoc test; **p < 0.01 As psoralens were shown to generate ROS in a variety of cell types in vitro (Iyama, Sato, Seto, & Onoue, 2019;Viola et al, 2008;Yang et al, 2015) and in vivo (Xia et al, 2018), we investigated to what extent the activation of TRPA1 by 8-MOP could be mediated by oxidative stress. The antioxidant and ROS scavenger N-acetyl cysteine completely abolished the 8-MOP-induced calcium transients in hTRPA1-expressing HEK293t cells.…”

Section: Discussionmentioning

confidence: 99%

“…As psoralens were shown to generate ROS in a variety of cell types in vitro (Iyama, Sato, Seto, & Onoue, 2019; Viola et al., 2008; Yang et al., 2015) and in vivo (Xia et al., 2018), we investigated to what extent the activation of TRPA1 by 8‐MOP could be mediated by oxidative stress. The antioxidant and ROS scavenger N‐acetyl cysteine completely abolished the 8‐MOP‐induced calcium transients in hTRPA1‐expressing HEK293t cells.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Psoralens activate and photosensitize Transient Receptor Potential channels Ankyrin type 1 (TRPA1) and Vanilloid type 1 (TRPV1)

Babeș

Kichko

Şelescu

et al. 2020

European Journal of Pain

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Psoralen is a naturally occurring furanocoumarin, found in the seeds of Psoralea corylifolia, and also in figs, celery, parsley and citrus fruits, which has been used to treat a number of skin conditions since the antiquity (Pathak & Fitzpatrick, 1992). In modern medicine, psoralen-derived compounds, such as 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen (5-MOP), are used in combination with UVA light (320-400 nm) exposure (PUVA therapy) to treat severe psoriasis, eczema, vitiligo, cutaneous T-cell lymphoma, mycosis fungoides and other conditions (Lapolla, Yentzer,

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Psoralens activate and photosensitize Transient Receptor Potential channels Ankyrin type 1 (TRPA1) and Vanilloid type 1 (TRPV1)

Babeș

Kichko

Şelescu

et al. 2020

European Journal of Pain

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“…MRT = 10 hr, (mean residence time) (Iyama, Sato, Seto, & Onoue, 2019a;Iyama, Sato, Seto, & Onoue, 2019b). XAT (IC 50 = 18 μM) showed maximum phototoxicity in Jurkat cells and…”

Section: Metabolism and Excretionmentioning

confidence: 99%

“…The latest report showed that 8‐MOP (50 μg/mL) is phytotoxin by conducting in vivo phototoxicity and by ROS analysis and PK test, and the in vivo phototoxicity results showed that T max = 4 hr, (time to maximum skin concentration); C max = 10.4 ± 1.7 (μg/g skin); MRT = 10 hr, (mean residence time) (Iyama, Sato, Seto, & Onoue, 2019a; Iyama, Sato, Seto, & Onoue, 2019b). XAT (IC 50 = 18 μM) showed maximum phototoxicity in Jurkat cells and HaCaT cells (Schempp, Simon‐Haarhaus, Krieger, & Simon, 2006).…”

Section: Toxicitymentioning

confidence: 99%

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Zhong

et al. 2022

Phytotherapy Research

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Xanthotoxin (XAT) is a natural furanocoumarins, a bioactive psoralen isolated from the fruit of the Rutaceae plant Pepper, which has received increasing attention in recent years due to its wide source and low cost. By collecting and compiling literature on XAT, the results show that XAT exhibits significant activity in the treatment of various diseases, including neuroprotection, skin repair, osteoprotection, organ protection, anticancer, antiinflammatory, antioxidative stress and antibacterial. In this paper, we review the pharmacological activity and potential molecular mechanisms of XAT for the treatment of related diseases. The data suggest that XAT can mechanistically induce ROS production and promote apoptosis through mitochondrial or endoplasmic reticulum pathways, regulate NF‐κB, MAPK, JAK/STAT, Nrf2/HO‐1, MAPK, AKT/mTOR, and ERK1/2 signaling pathways to exert pharmacological effects. In addition, the pharmacokinetics properties and toxicity of XAT are discussed in this paper, further elucidating the relationship between structure and efficacy. It is worth noting that data from clinical studies of XAT are still scarce, limiting the use of XAT in the clinic, and in the future, more in‐depth studies are needed to determine the clinical efficacy of XAT.

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Strategic photosafety screening system consisting of in chemico photoreactivity and in vitro skin exposure for quinolone derivatives

Iyama

Sato

Seto

et al. 2020

European Journal of Pharmaceutical Sciences

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Photochemical and Pharmacokinetic Characterization of Orally Administered Chemicals to Evaluate Phototoxic Risk

Cited by 5 publications

References 32 publications

Psoralens activate and photosensitize Transient Receptor Potential channels Ankyrin type 1 (TRPA1) and Vanilloid type 1 (TRPV1)

Psoralens activate and photosensitize Transient Receptor Potential channels Ankyrin type 1 (TRPA1) and Vanilloid type 1 (TRPV1)

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Strategic photosafety screening system consisting of in chemico photoreactivity and in vitro skin exposure for quinolone derivatives

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