Photocatalytic Quantum Dot‐Armed Bacteriophage for Combating Drug‐Resistant Bacterial Infection

Wang, Lei; Fan, Xin; Moreno, Mercedes Gonzalez; Tkhilaishvili, Tamta; Du, Weijie; Zhang, Xianlong; Nie, Chuanxiong; Trampuž, Andrej; Haag, Rainer

doi:10.1002/advs.202105668

Cited by 22 publications

(19 citation statements)

References 40 publications

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“…In addition, some new materials such as nanoparticles, a class of emerging antibacterial agents, exhibit an antibacterial mechanism that includes the destruction of bacterial biofilms, and many innovative anti-biofilm nanomedicines and nanomaterials have been developed for clinical treatment (Xiu et al, 2021). A recent study developed a novel photocatalytic quantum dot-armed bacteriophage nanosystem that combined phage therapy and photodynamic therapy, not only specifically binding to host P. aeruginosa, but also targeting host bacteria through the inherent infectivity of phages, locally generating massive amounts of ROS under visible light irradiation, and thereby demonstrating potent anti-biofilm activity (Wang et al, 2022). However, microorganisms adhere to the surfaces of medical devices and are prone to forming biofilms, leading to inevitable and challenging issues with P. aeruginosa biofilm infection caused by the use of clinical medical devices (Wi and Patel, 2018).…”

Section: Conclusion and Prospective Applicationsmentioning

confidence: 99%

Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies

et al. 2022

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Pseudomonas aeruginosa, a Gram-negative bacterium, is one of the major pathogens implicated in human opportunistic infection and a common cause of clinically persistent infections such as cystic fibrosis, urinary tract infections, and burn infections. The main reason for the persistence of P. aeruginosa infections is due to the ability of P. aeruginosa to secrete extracellular polymeric substances such as exopolysaccharides, matrix proteins, and extracellular DNA during invasion. These substances adhere to and wrap around bacterial cells to form a biofilm. Biofilm formation leads to multiple antibiotic resistance in P. aeruginosa, posing a significant challenge to conventional single antibiotic therapeutic approaches. It has therefore become particularly important to develop anti-biofilm drugs. In recent years, a number of new alternative drugs have been developed to treat P. aeruginosa infectious biofilms, including antimicrobial peptides, quorum-sensing inhibitors, bacteriophage therapy, and antimicrobial photodynamic therapy. This article briefly introduces the process and regulation of P. aeruginosa biofilm formation and reviews several developed anti-biofilm treatment technologies to provide new directions for the treatment of P. aeruginosa biofilm infection.

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Section: Conclusion and Prospective Applicationsmentioning

confidence: 99%

Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies

et al. 2022

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“…The proposed QD@Phage nanosystem not only specifically bound to the host GFP-P. aeruginosa while preserving the infectivity of the phage itself, but also showed a superior capacity for synergistic bacterial killing by phage and by the photocatalytic localized ROS generated from anchored QD component (Figure 36D). 297 In addition to the above modification methods, some emerging novel modification strategies have been developed for the construction of advanced and efficient photocatalytic antibacterial materials. For example, recent studies have shown that loading metal single atoms onto photocatalysts can greatly enhance the photoresponse performance of photocatalysts, the separation of e − /h + pairs, the catalytic surface reactions kinetics, and ultimately improve the ROS production efficiency and photocatalytic antibacterial performance.…”

Section: Constructing Heterostructures By Semiconductor Combinationmentioning

confidence: 99%

“…(D) A novel photocatalytic QD-armed bacteriophage: (I) a schematic illustration is provided to depict the phage-assisted photocatalytic therapy targeting GFP- P. aeruginosa ; (II) The bacterial viability of GFP- P. aeruginosa and MRSA after the light treatment with QD labeled phages. Reproduced with permission from ref . Copyright 2022, Wiley and Sons under [CC BY-NC-ND 4.0] [].…”

Section: Design Strategies For Improving Photocatalytic Performancementioning

confidence: 99%

Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Ran,

Wang

et al. 2023

Chem. Rev.

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Nowadays, the increasing emergence of antibiotic-resistant pathogenic microorganisms requires the search for alternative methods that do not cause drug resistance. Phototherapy strategies (PTs) based on the photoresponsive materials have become a new trend in the inactivation of pathogenic microorganisms due to their spatiotemporal controllability and negligible side effects. Among those phototherapy strategies, photocatalytic antimicrobial therapy (PCAT) has emerged as an effective and promising antimicrobial strategy in recent years. In the process of photocatalytic treatment, photocatalytic materials are excited by different wavelengths of lights to produce reactive oxygen species (ROS) or other toxic species for the killing of various pathogenic microbes, such as bacteria, viruses, fungi, parasites, and algae. Therefore, this review timely summarizes the latest progress in the PCAT field, with emphasis on the development of various photocatalytic antimicrobials (PCAMs), the underlying antimicrobial mechanisms, the design strategies, and the multiple practical antimicrobial applications in local infections therapy, personal protective equipment, water purification, antimicrobial coatings, wound dressings, food safety, antibacterial textiles, and air purification. Meanwhile, we also present the challenges and perspectives of widespread practical implementation of PCAT as antimicrobial therapeutics. We hope that as a result of this review, PCAT will flourish and become an effective weapon against pathogenic microorganisms and antibiotic resistance.

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“…[9] To overcome these limitations, Peng et al [10] prepared chimeric M13 phages to broaden the antibacterial spectrum and combined with gold nanorods to ablate various bacterial species by photothermal ablation. Wang et al [11] reported a photocatalytic quantum-dot-armed phage (QD@phage) for combating Pseudomonas aeruginosa infection. QD@phage preserved specifically binding ability of phages to assist QD localization on the surfaces of bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…Wang et al. [ 11 ] reported a photocatalytic quantum‐dot‐armed phage (QD@phage) for combating Pseudomonas aeruginosa infection. QD@phage preserved specifically binding ability of phages to assist QD localization on the surfaces of bacteria.…”

Section: Introductionmentioning

confidence: 99%

Microenvironment‐Activated Nanozyme‐Armed Bacteriophages Efficiently Combat Bacterial Infection

et al. 2023

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Bacterial infection is one of the greatest challenges to public health, requiring new therapeutic methods. Herein, an innovative nanozyme‐armed phage (phage@palladium (Pd)) system is fabricated for combating bacterial infection. The proposed phage@Pd preserves the function of the phages to achieve precise recognition and adhesion to the host Escherichia coli. In aid of the phages, the ultrasmall Pd nanozymes equipped with conspicuous pH‐dependent peroxidase‐like activity can generate toxic hydroxyl radical around the bacteria in acidic and hydrogen‐peroxide‐overexpressed infection microenvironment while remaining inert in physiological conditions, thus realizing the noteworthy elimination of bacteria at infected sites, and in the meantime ensuring the biological safety of phage@Pd in healthy tissues. In addition, the filamentous structure of phage@Pd can also enhance its bactericidal efficiency toward nonhost bacteria by randomly entangling on them, indicating possible broad‐spectrum germicidal efficacy. Notably, phage@Pd can not only eradicate planktonic bacteria, but also kill the bacteria inside the biofilm in vitro. For both in vivo models of acute bacterial pneumonia or subcutaneous abscess, phage@Pd shows significant activity in eliminating infection and promoting tissue recovery. These results demonstrate that the phage@Pd nanohybrid is a safe and effective antimicrobial agent, providing a new insight into development of advanced antibacterial materials.

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Photocatalytic Quantum Dot‐Armed Bacteriophage for Combating Drug‐Resistant Bacterial Infection

Cited by 22 publications

References 40 publications

Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies

Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies

Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Microenvironment‐Activated Nanozyme‐Armed Bacteriophages Efficiently Combat Bacterial Infection

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