Photocatalytic C(sp<sup>3</sup>) radical generation<i>via</i>C–H, C–C, and C–X bond cleavage

Huang, Chun-Hong; Li, Jianbin; Li, Chao‐Jun

doi:10.1039/d2sc00202g

Cited by 76 publications

(44 citation statements)

References 220 publications

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“…An increasing body of research from recent years has shown that the intake, digestion, and absorption of dietary meat protein can significantly affect physiological functions and metabolic changes. [ 11–13,27 ] The results of this study indicate that compared with the XWH0 and XWH1 groups, the body weight gain and epididymal fat weight decreased after XWH2 and XWH3 intake, suggesting that the prolonging of ripening period of Xuanwei ham may affect its nutrient digestibility and fat accumulation. Casein intake has been reported to help prevent weight gain among the protein sources tested, [ 28,29 ] and was consistent with the body weight change in Casein group observed in this study.…”

Section: Discussionmentioning

confidence: 83%

Effect of Xuanwei Ham Proteins with Different Ripening Periods on Lipid Metabolism, Oxidative Stress, and Gut Microbiota in Mice

Guo

Xie

et al. 2022

Molecular Nutrition Food Res

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Scope: Consumption of dry-cured ham may have a cardiovascular disease preventive capacity. However, whether ham protein in the maintenance of health and prevention of disease is dependent on ripening periods need to be clarified. Methods and results: Fifty C57BL/6 mice consume a diet that contains either Casein, raw ham protein (XWH0), or Xuanwei ham protein after 1-, 2-, or 3-years of maturation (XWH1, XWH2, or XWH3) for 4 weeks. Results show that longer ripening periods in the Xuanwei ham groups are negatively correlated with body weight gain, adipose tissue weight, total cholesterol (TC), and triglycerides levels in serum and liver, and these proteins intake could maintain liver health, reduce lipid deposition and oxidative stress, regulate lipid metabolism-related genes expression, alter the gut microbiota, and promote short-chain fatty acid production. Remarkably, XWH3 intake maintains lower TC and low-density lipoprotein cholesterol levels in serum and has high antioxidative activity as well. This regulation of lipid metabolism and oxidative stress may be related to the AMPK/Nrf2 signaling. Conclusion: Xuanwei ham dietary proteins that have endured a specific ripening period may have preventive effects on metabolic syndrome, which provide a basis for new ideas for nutritional health interventions.

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Section: Discussionmentioning

confidence: 83%

Effect of Xuanwei Ham Proteins with Different Ripening Periods on Lipid Metabolism, Oxidative Stress, and Gut Microbiota in Mice

Guo

Xie

et al. 2022

Molecular Nutrition Food Res

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“…Pioneered by MacMillan, Molander and others ( Chan et al., 2022 ; Huang et al., 2022 ; Tellis et al., 2016 ; Twilton et al., 2017 ), metallaphotoredox cross-couplings have gained exponential growth in both academic and industrial platforms for the last decade. These novel synthetic paradigms could synergize the advantages of rapidly developed molecular photochemistry and well-established transition metal catalysis, thus opening uncharted chemical space for new mechanistic insights and long-sought-after reactivities.…”

Section: Before You Beginmentioning

confidence: 99%

A ligand-enabled metallaphotoredox protocol for Suzuki-Miyaura cross-couplings for the synthesis of diarylmethanes

Li¹,

Huang²,

Li³

2022

STAR Protocols

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“…Escitalopram is primarily metabolized in the liver by cytochrome P (CYP)450, particularly CYP2C19, which is a highly polymorphic enzyme that causes interindividual pharmacokinetic differences (Rao, 2007;Pastoor and Gobburu, 2014), and is excreted mainly through the kidneys. The effect of age (Dolder et al, 2010;Yang and Scott, 2010), gender (Montejo et al, 2015), smoking (Oliveira et al, 2017;Scherf-Clavel et al, 2019), CYP2C19 phenotype (Huang et al, 2021), hepatic impairment (Areberg et al, 2006), and renal impairment (Dolder et al, 2010) on the pharmacokinetics of escitalopram have been investigated. The findings of these studies were instrumental in developing specific dosing recommendations for escitalopram for specific populations (Hicks et al, 2015;Brouwer et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Population pharmacokinetics model for escitalopram in Chinese psychiatric patients: effect of CYP2C19 and age

et al. 2022

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Objective: To establish a population pharmacokinetic model in Chinese psychiatric patients to characterize escitalopram pharmacokinetic profile to identify factors influencing drug exposure, and through simulation to compare the results with the established therapeutic reference range.Methods: Demographic information, dosing regimen, CYP2C19 genotype, concomitant medications, and liver and kidney function indicators were retrospectively collected for inpatients taking escitalopram with therapeutic drug monitoring from 2018 to 2021. Nonlinear mixed-effects modeling was used to model the pharmacokinetic characteristics of escitalopram. Goodness-of-fit plots, bootstrapping, and normalized prediction distribution errors were used to evaluate the model. Simulation for different dosing regimens was based on the final estimations.Results: The study comprised 106 patients and 337 measurements of serum sample. A structural model with one compartment with first-order absorption and elimination described the data adequately. The population-estimated apparent volume of distribution and apparent clearance were 815 and 16.3 L/h, respectively. Age and CYP2C19 phenotype had a significant effect on the apparent clearance (CL/F). CL/F of escitalopram decreased with increased age, and CL/F of poor metabolizer patients was significantly lower than in extensive and immediate metabolizer patients. The final model-based simulation showed that the daily dose of adolescents with poor metabolizer might be as high as 15 mg or 20 mg and referring to the therapeutic range for adults may result in overdose and a high risk of adverse effects in older patients.Conclusion: A population pharmacokinetics model of escitalopram was successfully created for the Chinese population. Depending on the age of the patients, CYP2C19 genotype and serum drug concentrations throughout treatment are required for adequate individualization of dosing regimens. When developing a regimen for older patients, especially those who are poor metabolizers, vigilance is required.

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Photocatalytic C(sp³) radical generationviaC–H, C–C, and C–X bond cleavage

Abstract: C(sp3) radicals (R·) are of broad research interest and synthetic utility. This review collects some of the most recent advancements in photocatalytic R· generation and highlights representative examples in this...

Cited by 76 publications

References 220 publications

Effect of Xuanwei Ham Proteins with Different Ripening Periods on Lipid Metabolism, Oxidative Stress, and Gut Microbiota in Mice

Effect of Xuanwei Ham Proteins with Different Ripening Periods on Lipid Metabolism, Oxidative Stress, and Gut Microbiota in Mice

A ligand-enabled metallaphotoredox protocol for Suzuki-Miyaura cross-couplings for the synthesis of diarylmethanes

Population pharmacokinetics model for escitalopram in Chinese psychiatric patients: effect of CYP2C19 and age

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Photocatalytic C(sp3) radical generationviaC–H, C–C, and C–X bond cleavage

Abstract: C(sp3) radicals (R·) are of broad research interest and synthetic utility. This review collects some of the most recent advancements in photocatalytic R· generation and highlights representative examples in this...

Cited by 76 publications

References 220 publications

Effect of Xuanwei Ham Proteins with Different Ripening Periods on Lipid Metabolism, Oxidative Stress, and Gut Microbiota in Mice

Effect of Xuanwei Ham Proteins with Different Ripening Periods on Lipid Metabolism, Oxidative Stress, and Gut Microbiota in Mice

A ligand-enabled metallaphotoredox protocol for Suzuki-Miyaura cross-couplings for the synthesis of diarylmethanes

Population pharmacokinetics model for escitalopram in Chinese psychiatric patients: effect of CYP2C19 and age

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Resources

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Photocatalytic C(sp³) radical generationviaC–H, C–C, and C–X bond cleavage