“…Compared with conventional C1 synthons such as DMF, DMSO, formaldehyde, and methanol, DMEA has shown some unique activities. For instance, with the same catalyst and substrates, Zhang’s group found that amidines reacted with DMSO to afford quinazolines, while we found that 1,3,5-triazine derivatives were obtained when DMEA was utilized as a C1 synthon instead of DMSO. , Inspired by these findings and driven by our continuous interest in the synthesis of heterocycles, the construction of 2 H -chromenes involving DMEA was attempted. Herein, we wish to report an unprecedented Cu(II)-catalyzed [3 + 1+1 + 1] annulation for the efficient synthesis of 2 H -chromenes from 2-naphthols, 1,3-diketones, and DMEA via two discrete homologations (Scheme c).…”