Photocatalytic Alkylation of α-(Trifluoromethyl)Styrenes with Potassium Xanthogenates

Abstract

A protocol for the coupling of potassium xanthogenates with α-(trifluoromethyl)styrenes in the presence of triethyl phosphite is reported. The reaction is carried out under blue light irradiation in the presence of organic photocatalyst 3DPAFIPN. The reaction proceeds via formation of alkyl radicals from readily available xanthogenate salts via oxidative desulfurization and cleavage of the carbon–oxygen bond assisted by triethyl phosphite.

Nickel-Catalyzed Cross-Electrophile Coupling Reactions between Allylic Acetates and gem-Difluorovinyl Tosylate

“…Traditionally, gem -difluoroolefins are synthesized by the Wittig difluoromethylenation of aldehydes or ketones, the Horner–Wadsworth–Emmons reaction, and the Julia–Kocienski reaction . Other strategies to construct a difluoromethylene (CF 2 ) group include gem -difluoroolefination of diazo compounds and defluoroolefination of CF 3 -substituted alkenes by transition metal catalysis or photocatalysis …”