Photobiostimulation on Wound Healing Treatment by ClAlPc-nanoemulsion from a Multiple-Wavelength Portable Light Source on a 3D-Human Stem Cell Dermal Equivalent

Primo, Fernando Lucas; Paula, Leonardo Barcelos de; Siqueira-Moura, Marigilson P.; Tedesco, Antônio Cláudio

doi:10.2174/092986712803530502

Cited by 25 publications

(18 citation statements)

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“…The development of DDS has been proposed as an excellent strategy for overcoming cellular resistance mechanisms and improving the selectivity of the drug for cancer cells while also reducing side effects (Chatterjee et al 2008;Primo et al 2008Primo et al , 2012de Paula et al 2013de Paula et al , 2015Bolfarini et al 2014). These systems are also responsible for the stability of unstable cytotoxic compounds in a biological medium (Niziolek et al 2003;Tada 2007).…”

Section: Drug Delivery Systemmentioning

confidence: 99%

Nanomedicine associated with photodynamic therapy for glioblastoma treatment

2017

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Glioblastoma, also known as glioblastoma multiforme (GBM), is the most recurrent and malignant astrocytic glioma found in adults. Biologically, GBMs are highly aggressive tumors that often show diffuse infiltration of the brain parenchyma, making complete surgical resection difficult. GBM is not curable with surgery alone because tumor cells typically invade the surrounding brain, rendering complete resection unsafe. Consequently, present-day therapy for malignant glioma remains a great challenge. The location of the invasive tumor cells presents several barriers to therapeutic delivery. The blood-brain barrier regulates the trafficking of molecules to and from the brain. While high-grade brain tumors contain some "leakiness" in their neovasculature, the mechanisms of GBM onset and progression remain largely unknown. Recent advances in the understanding of the signaling pathways that underlie GBM pathogenesis have led to the development of new therapeutic approaches targeting multiple oncogenic signaling aberrations associated with the GBM. Among these, drug delivery nanosystems have been produced to target therapeutic agents and improve their biodistribution and therapeutic index in the tumor. These systems mainly include polymer or lipid-based carriers such as liposomes, metal nanoparticles, polymeric nanospheres and nanocapsules, micelles, dendrimers, nanocrystals, and nanogold. Photodynamic therapy (PDT) is a promising treatment for a variety of oncological diseases. PDT is an efficient, simple, and versatile method that is based on a combination of a photosensitive drug and light (generally laser-diode or laser); these factors are separately relatively harmless but when used together in the presence of oxygen molecules, free radicals are produced that initiate a sequence of biological events, including phototoxicity, vascular damage, and immune responses. Photodynamic pathways activate a cascade of activities, including apoptotic and necrotic cell death in both the tumor and the neovasculature, leading to a permanent lesion and destruction of GBM cells that remain in the healthy tissue. Glioblastoma tumors differ at the molecular level. For example, gene amplification epidermal growth factor receptor and its receptor are more highly expressed in primary GBM than in secondary GBM. Despite these distinguishing features, both types of tumors (primary and secondary) arise as a result dysregulation of numerous intracellular signaling pathways and have standard features, such as increased cell proliferation, survival and resistance to apoptosis, and loss of adhesion and migration, and may show a high degree of invasiveness. PDT may promote significant tumor regression and extend the lifetime of patients who experience glioma progression.

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Section: Drug Delivery Systemmentioning

confidence: 99%

Nanomedicine associated with photodynamic therapy for glioblastoma treatment

2017

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“…Photodynamic therapy (PDT) is a promising treatment for cancer and non-oncological diseases. [1][2][3][4] It combines a photosensitizer drug (PS, organic dye) with visible light irradiation in the range of the electromagnetic spectrum of appropriate wavelength, and oxygen, each of which alone is harmless. The photodynamic effect produces reactive oxygen species (ROS), which function as lethal cytotoxic agents that inactivate tumor cells, bacteria and other living species.…”

Section: Introductionmentioning

confidence: 99%

“…The advantage of PDT over other clinical procedures is that it has no toxic side effects and it can be applied repeatedly, over a short period of time, with low risk to the patient. 2 PDT has also been frequently used for photodiagnostic purposes, since most of the PS used have the ability to absorb light and to produce active species (ROS) or emit light as fluorescent probes for diagnosis. 16 Given that PDT has become a first choice treatment for many diseases, and in view of the absence of data showing the effect of PDT on the nervous system, the objective of this study was to analyze this behavior and to elect PDT for application as a therapeutic treatment for spinal diseases.…”

Section: Introductionmentioning

confidence: 99%

Experimental Study of the Neurotoxic Effects of Photodynamic Therapy on the Spinal Cord

et al. 2019

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Objective To evaluate the effects of photodynamic therapy (PDT) on the dura mater using the photosensitizers aluminum chloride phthalocyanine and methylene blue in in vivo assays. Methods Fifty-six male Wistar rats were divided into two groups; one submitted to PDT and the other submitted to the photosensitizers without their photoactivation (control). The photosensitizers were applied to the dura mater after laminectomy at the T10 level. The methods used for assessment were the Basso, Beattie and Bresnahan (BBB) functional evaluation scale and study of the dura mater by light microscopy. Results No changes in motor activity were observed in the animals submitted to PDT compared to control. Histological and pathological evaluation did not show any differences between the group exposed to activated photosensitizers and the control group with regard to the inflammatory process and tissue necrosis. Conclusion The joint use of PDT with the photosensitizing pharmaceuticals aluminum chloride phthalocyanine and methylene blue did not induce any clinical neurotoxic effects or histological changes in the dura mater of the animals studied. Level de evidence V; Expert Opnion.

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“…PD or light alone does not exhibit cytotoxicity. This innovative technique has been used successfully in the treatment of skin cancer, based on the evidence that the drug has low toxicity in the absence of light and tend to accumulate in the diseased tissue. The PDT results have generated a recent increase in the development and synthesis of new drugs.…”

Section: Introductionmentioning

confidence: 99%