Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models

Ye, Feng; Yang, Luodan; Ma, Xiaohui; Huang, Zhihai; Zong, Xin; Citadin, Cristiane T.; Lin, Hung Wen; Zhang, Quanguang

doi:10.1016/j.neuint.2022.105464

Cited by 12 publications

(5 citation statements)

References 46 publications

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“…In contrast, the cortex has markedly neuronal damage and increased apoptosis-associated proteins. Strikingly, PBM significantly prevents neuronal damage and apoptosisassociated proteins increase, which is similar to previous findings that PBM exerts neuroprotective effects in brain injury and neurodegenerative diseases [5,8,21,22]. Additionally, astrocytes support and nourish neurons as the principal glial cells in the central nervous system [37,38].…”

Section: Discussionsupporting

confidence: 86%

“…In our previous studies, 808 nm near-infrared (NIR) has shown a potent neuroprotective effect in various brain disorders. Therefore, in the current, PBM therapy with 808 nm near-infrared (NIR) was conducted to alleviate repeated closed-head injury-induced anxiety-like behaviors [5,8,[21][22][23][24]. Thus, the mechanism underlying the beneficial effects of PBM also expands to the regulation of mitochondria-associated processes, including preserving mitochondrial dynamics and reducing oxidative stress and neuroinflammation [6,7,14,15,19].…”

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confidence: 99%

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Photobiomodulation therapy alleviates repeated closed head injury‐induced anxiety‐like behaviors

Chen,

Li,

et al. 2023

Journal of Biophotonics

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Repeated closed head injury (rCHI) is one of the most common brain injuries. Although extensive studies have focused on how to treat rCHI‐induced brain injury and reduce the possibility of developing memory deficits, the prevention of rCHI‐induced anxiety has received little research attention. The current study was designed to assess the effects of photobiomodulation (PBM) therapy in preventing anxiety following rCHI. The rCHI disease model was constructed by administering three repeated closed‐head injuries within an interval 5 days. 2‐min daily PBM therapy using an 808 nm continuous wave laser at 350 mW/cm2 on the scalp was implemented for 20 days. We found that PBM significantly ameliorated rCHII‐induced anxiety‐like behaviors, neuronal apoptosis, neuronal injury, promotes astrocyte/microglial polarization to anti‐inflammatory phenotype, preserves mitochondrial fusion‐related protein MFN2, attenuates the elevated mitochondrial fission‐related protein DRP1, and mitigates neuronal senescence. We concluded that PBM therapy possesses great potential in preventing anxiety following rCHI.

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Section: Discussionsupporting

confidence: 86%

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confidence: 99%

Photobiomodulation therapy alleviates repeated closed head injury‐induced anxiety‐like behaviors

Chen,

Li,

et al. 2023

Journal of Biophotonics

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“…The PT model was to produce a more reproducible cortical infarct without craniotomy in rats. The PT stroke model was established following the methodology outlined in our previous study [ 21 ]. Briefly, rats were initially anesthetized with isoflurane and securely placed in a stereotactic frame.…”

Section: Methodsmentioning

confidence: 99%

Photobiomodulation Inhibits Ischemia-Induced Brain Endothelial Senescence via Endothelial Nitric Oxide Synthase

Feng,

Huang,

et al. 2024

Antioxidants

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Recent research suggests that photobiomodulation therapy (PBMT) positively impacts the vascular function associated with various cerebrovascular diseases. Nevertheless, the specific mechanisms by which PBMT improves vascular function remain ambiguous. Since endothelial nitric oxide synthase (eNOS) is crucial in regulating vascular function following cerebral ischemia, we investigated whether eNOS is a key element controlling cerebrovascular function and the senescence of vascular endothelial cells following PBMT treatment. Both rat photothrombotic (PT) stroke and in vitro oxygen–glucose deprivation (OGD)-induced vascular endothelial injury models were utilized. We demonstrated that treatment with PBMT (808 nm, 350 mW/cm2, 2 min/day) for 7 days significantly reduced PT-stroke-induced vascular permeability. Additionally, PBMT inhibited the levels of endothelial senescence markers (senescence green and p21) and antiangiogenic factor (endostatin), while increasing the phospho-eNOS (Ser1177) in the peri-infarct region following PT stroke. In vitro study further indicated that OGD increased p21, endostatin, and DNA damage (γH2AX) levels in the brain endothelial cell line, but they were reversed by PBMT. Intriguingly, the beneficial effects of PBMT were attenuated by a NOS inhibitor. In summary, these findings provide novel insights into the role of eNOS in PBMT-mediated protection against cerebrovascular senescence and endothelial dysfunction following ischemia. The use of PBMT as a therapeutic is a promising strategy to improve endothelial function in cerebrovascular disease.

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“…Transcranial PBM may also affect intraneuronal signaling. In cultured primary neurons, PBM treatment mitigated neuronal damage induced by oxygen and glucose deprivation, leading to the restoration of neuronal viability [ 78 ]. Nevertheless, the potential effects of transcranial PBM on intraneuronal signaling in the context of AD remain to be demonstrated by future research.…”

Section: Biological Mechanisms Underlying the Benefits Of Transcrania...mentioning

confidence: 99%

Photobiomodulation in experimental models of Alzheimer’s disease: state-of-the-art and translational perspectives

Huang,

Hamblin,

Zhang

2024

Alz Res Therapy

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Alzheimer’s disease (AD) poses a significant public health problem, affecting millions of people across the world. Despite decades of research into therapeutic strategies for AD, effective prevention or treatment for this devastating disorder remains elusive. In this review, we discuss the potential of photobiomodulation (PBM) for preventing and alleviating AD-associated pathologies, with a focus on the biological mechanisms underlying this therapy. Future research directions and guidance for clinical practice for this non-invasive and non-pharmacological therapy are also highlighted. The available evidence indicates that different treatment paradigms, including transcranial and systemic PBM, along with the recently proposed remote PBM, all could be promising for AD. PBM exerts diverse biological effects, such as enhancing mitochondrial function, mitigating the neuroinflammation caused by activated glial cells, increasing cerebral perfusion, improving glymphatic drainage, regulating the gut microbiome, boosting myokine production, and modulating the immune system. We suggest that PBM may serve as a powerful therapeutic intervention for AD.

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Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models

Cited by 12 publications

References 46 publications

Photobiomodulation therapy alleviates repeated closed head injury‐induced anxiety‐like behaviors

Photobiomodulation therapy alleviates repeated closed head injury‐induced anxiety‐like behaviors

Photobiomodulation Inhibits Ischemia-Induced Brain Endothelial Senescence via Endothelial Nitric Oxide Synthase

Photobiomodulation in experimental models of Alzheimer’s disease: state-of-the-art and translational perspectives

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