Photobiomodulation therapy on expression of HSP70 protein and tissue repair in experimental acute Achilles tendinitis

Evangelista, André Nobre; Santos, Flávia Franciele dos; Martins, Lorena Pacheco de Oliveira; Gaiad, Thaís Peixoto; Machado, Alex Sander Dias; Rocha‐Vieira, Etel; Costa, Karine Beatriz; Santos, Ana Paula; Oliveira, Murilo Xavier

doi:10.1007/s10103-020-03155-3

Cited by 12 publications

(5 citation statements)

References 32 publications

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“…Additionally, HSP70 plays an important role in skin rejuvenation by supporting the synthesis, folding, and transport of collagen, and HSP90 increases the wound healing process by promoting the migration of cells that are present near the wound site. 6 , 74 , 75 It has been demonstrated that the expression of HSP27, 70, and 90 is promoted by PBM, 74 , 75 and the activated expression of HSP27, 70, and 90 would have a positive effect on wound healing and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Lightwave-reinforced stem cells with enhanced wound healing efficacy

Jeon

Kim

et al. 2021

J Tissue Eng

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Comprehensive research has led to significant preclinical outcomes in modified human adipose-derived mesenchymal stem cells (hADSCs). Photobiomodulation (PBM), a technique to enhance the cellular capacity of stem cells, has attracted considerable attention owing to its effectiveness and safety. Here, we suggest a red organic light-emitting diode (OLED)-based PBM strategy to augment the therapeutic efficacy of hADSCs. In vitro assessments revealed that hADSCs basked in red OLED light exhibited enhanced angiogenesis, cell adhesion, and migration compared to naïve hADSCs. We demonstrated that the enhancement of cellular capacity was due to an increased level of intracellular reactive oxygen species. Furthermore, accelerated healing and regulated inflammatory response was observed in mice transplanted with red light-basked hADSCs. Overall, our findings suggest that OLED-based PBM may be an easily accessible and attractive approach for tissue regeneration that can be applied to various clinical stem cell therapies.

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Section: Discussionmentioning

confidence: 99%

Lightwave-reinforced stem cells with enhanced wound healing efficacy

Jeon

Kim

et al. 2021

J Tissue Eng

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“…In 2020, another study demonstrated the tissue repair potential of red LED in an experimental rat model of Achilles tendonitis. The authors observed an increase in the number of fibroblasts, as well as in the amount of collagen and the expression of HSP70 (Evangelista et al, 2020).…”

Section: Vitoriano Et Al (2019)mentioning

confidence: 91%

Effects of light-emitting diodes on cell biology

Veloso

Fonseca

Santos³

2022

Front. Photon.

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Currently, light-emitting diodes (LEDs) are considered a substitute for low-power lasers in phototherapy protocols. LEDs enable photobiomodulation on biological tissues and are considered safe and economical. However, the molecular and metabolic mechanisms involved in LED-induced photobiomodulation are not yet fully understood. This review summarizes the metabolic mechanisms involved in LED-induced photobiomodulation in biological tissues under different irradiation parameters and conditions. Studies on LED-induced metabolism photobiomodulation were accessed using scientific article databases, whose findings were summarized in terms of molecular and cellular mechanisms. Data from the accessed studies suggested that the molecular mechanism of LED-induced photobiomodulation involves photoacceptors, such as cytochrome C oxidase, membrane ion channels, mitochondrial modulation, and the production of ROS.

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“…The overexpression of HSP may be a protective responses of tendon cells to repetitive injuries as the expression of HSP72 was downregulated in the rat tendon injury model and the overexpression of HSP72 reduced tendon inflammation, inflammatory cell infiltration and fibrosis [ 103 ]. The overexpression of HSP70 was also associated with tendon repair after photobiomodulation therapy in another study [ 104 ].…”

Section: Common Inflammatory Mediators Linking Obesity and Tendinopathymentioning

confidence: 99%

Inflammatory mechanisms linking obesity and tendinopathy

Lui

Yung

2021

Journal of Orthopaedic Translation

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Chronic tendinopathy is a debilitating tendon disorder with disappointing treatment outcomes. This review focuses on the potential roles of chronic low-grade inflammation in promoting tendinopathy in obesity. A systematic literature search was performed to identify all clinical studies supporting the actions of obesity-associated inflammatory mediators in the development of tendinopathy. The mechanisms of obesity-induced chronic inflammation in adipose tissue are firstly reviewed. Common inflammatory mediators potentially linking obesity and the development of tendinopathy, and their association with mechanical overuse, are discussed, along with pre-clinical evidences and a systematic literature search on clinical studies. The potential contribution of local adipose tissues in the promotion of inflammation, pain and tendon degeneration is then discussed. The future research directions are proposed. Translational potential statement Better understanding of the roles of obesity-associated inflammatory mediators on tendons will clarify the pathophysiological drivers of tendinopathy in patients with obesity and identify possible treatment targets. Further studies on the mechanisms of obesity-induced chronic inflammation on tendon are a promising direction for the treatment of tendinopathy.

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Photobiomodulation therapy on expression of HSP70 protein and tissue repair in experimental acute Achilles tendinitis

Cited by 12 publications

References 32 publications

Lightwave-reinforced stem cells with enhanced wound healing efficacy

Lightwave-reinforced stem cells with enhanced wound healing efficacy

Effects of light-emitting diodes on cell biology

Inflammatory mechanisms linking obesity and tendinopathy

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