Photobiomodulation therapy for male infertility

Zupin, Luisa; Pascolo, Lorella; Luppi, Stefania; Ottaviani, Giulia; Crovella, Sérgio; Ricci, Giuseppe

doi:10.1007/s10103-020-03042-x

Cited by 11 publications

(10 citation statements)

References 53 publications

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“…The presence of opsins in the spermatozoa, the modification of the mitochondrial activity, and activation of plasma membrane receptors from the transient receptor potential (TRP) family of proteins have been suggested as possible mechanisms of action of the illumination on the sperm functionality [21][22][23][24][25]. However, in this study, these reported changes in the sperm parameters had no effect on the subsequent reproductive outcomes, measured in terms of farrowing rate and litter size under commercial conditions.…”

Section: Discussionmentioning

confidence: 60%

Photo Stimulation of Seminal Doses with Red LED Light from Duroc Boars and Resultant Fertility in Iberian Sows

Crespo

Martínez²,

Gadea

2021

Animals

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In pigs, it has been reported that increased farrowing rates and litter size have been induced by photostimulating the seminal doses for artificial insemination with red LED light. As the reproductive characteristics, production system, and outcome parameters of Iberian breed pigs are different from other commercial breeds, the aim of this study was to evaluate the possible effect of illuminating seminal doses from Duroc boars with red LED light and the fertility outcomes of Iberian females. Semen samples were obtained from 38 fertile Duroc boars. Photostimulation of the artificial insemination (AI) seminal doses was carried out by illuminating the samples with a red LED for 10 min, followed by 10 min of darkness, and finally 10 additional minutes of red light. The fertility study was conducted on two commercial farms using multiparous Iberian sows (farm A, n = 824; farm B, n = 2131), that were randomly assigned to LED (L) or control (C) groups. No differences were found between L and C groups in both farms (p > 0.05) for parity, pregnancy rate, duration of pregnancy, farrowing rate, and litter size (total, alive, and stillborn piglets). Farrowing rates in farm A were 88.8% (n = 383) for control and 89.6% (n = 441, p = 0.67) for the LED group. In farm B, farrowing rates were C:90.5% (n = 1030) and L: 90.1% (n = 1101, p = 0.48). In farm A, total born piglets were 8.69 ± 0.11 for C and 8.71 ± 0.11 for L (p = 0.87). In farm B, the results were 8.72 ± 0.7 for C and 8.70 ± 0.06 (p = 0.82) for L. Under the production conditions for the Iberian breed, the photostimulation with red LED light using Duroc pig seminal doses was not effective in improving the fertility of Iberian sows.

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Section: Discussionmentioning

confidence: 60%

Photo Stimulation of Seminal Doses with Red LED Light from Duroc Boars and Resultant Fertility in Iberian Sows

Crespo

Martínez²,

Gadea

2021

Animals

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“…Considered to be the mainstream treatment method for the estrogen receptor-positive breast cancer treatment regimen, aromatase inhibitors have been continuously used under the title of first-, second-, and third-generation aromatase inhibitors as approved by the FDA. The third-generation inhibitors comprise of letrozole, anastrozole, and exemestanea, which are used in the standard treatment of postmenopausal breast cancer these days. , In many studies, their use has been reported in reproductive technology, endometriosis, gynecomastia, ovarian cancers, male infertility, and many others …”

Section: Introductionmentioning

confidence: 99%

“…The third-generation inhibitors comprise of letrozole, anastrozole, and exemestanea, which are used in the standard treatment of postmenopausal breast cancer these days. 6,7 In many studies, their use has been reported in reproductive technology, 8 endometriosis, 9 gynecomastia, 10 ovarian cancers, 11 male infertility, 12 and many others. 13 Although the treatment using both steroidal and nonsteroidal aromatase inhibitors as third-generation aromatase inhibitors has gained tremendous attention, a few major side effects such as arthralgia, myalgia, hot flashes, night sweats, loss of sex drive, and vaginal dryness were observed in case of their prolonged clinical usage.…”

Section: Introductionmentioning

confidence: 99%

Machine Learning-Assisted Prediction of the Biological Activity of Aromatase Inhibitors and Data Mining to Explore Similar Compounds

et al. 2022

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Designing molecules for drugs has been a hot topic for many decades. However, it is hard and expensive to find a new molecule. Thus, the cost of the final drug is also increased. Machine learning can provide the fastest way to predict the biological activity of druglike molecules. In the present work, machine learning models are trained for the prediction of the biological activity of aromatase inhibitors. Data was collected from the literature. Molecular descriptors are calculated to be used as independent features for model training. The results showed that the R 2 values for linear regression, random forest regression, gradient boosting regression, and bagging regression are 0.58, 0.84, 0.77, and 0.80, respectively. Using these models, it is possible to predict the activity of new molecules in a short period of time and at a reasonable cost. Furthermore, Tanimoto similarity is used for similarity analysis, as well as a chemical database is mined to search for similar molecules. Nonetheless, this study provides a framework for repurposing other effective drug molecules to prevent cancer.

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“…Men infertility affects more than 12% of the whole population and it is considered a multifactorial phenomenon [ 3 , 4 ]. It is widely accepted that medical intervention, i.e., Assisted Reproductive Techniques (ART), could be employed to circumvent male factors to some extent [ 5 , 6 ] and this implies a proper male gamete selection. However, the routinary semen analysis does not investigate possible sperm nucleic acids alteration such as DNA fragmentation, damage or epigenetic modifications (i.e., DNA methylation) [ 7 ], which significantly modify the semen quality parameters as well as the fertilization and implantation rates [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Strategies and Perspectives for UV Resonance Raman Applicability in Clinical Analyses of Human Sperm RNA

Pachetti

D’Amico

Zupin

et al. 2021

IJMS

Self Cite

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Developing a deeper knowledge about the impact of DNA and RNA epigenetic mutations on sperm production and fertilization performance is essential for selecting best quality samples in Assisted Reproductive Technologies (ART). Indeed, sperm RNAs adenine and guanine are likely to be methylated in low quality RNA sperm samples and their study requires the employment of techniques able to isolate high quality nucleic acids. UV resonance Raman spectroscopy represents a valuable tool that is able to monitor peculiar molecular modifications occurring predominantly in nucleic acids, being less sensitive to the presence of other biological compounds. In this work, we used an UV Resonance Raman (UVRR) setup coupled to a synchrotron radiation source tuned at 250 nm, in order to enhance sperm RNAs adenine and guanine vibrational signals, reducing also the impact of a fluorescence background typically occurring at lower energies. Despite that our protocol should be further optimized and further analyses are requested, our results support the concept that UVRR can be applied for setting inexpensive tools to be employed for semen quality assessment in ART.

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Photobiomodulation therapy for male infertility

Cited by 11 publications

References 53 publications

Photo Stimulation of Seminal Doses with Red LED Light from Duroc Boars and Resultant Fertility in Iberian Sows

Photo Stimulation of Seminal Doses with Red LED Light from Duroc Boars and Resultant Fertility in Iberian Sows

Machine Learning-Assisted Prediction of the Biological Activity of Aromatase Inhibitors and Data Mining to Explore Similar Compounds

Strategies and Perspectives for UV Resonance Raman Applicability in Clinical Analyses of Human Sperm RNA

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