Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat

Micheli, Laura; Mannelli, Lorenzo Di Cesare; Lucarini, Elena; Cialdai, Francesca; Vignali, Leonardo; Ghelardini, Carla; Monici, Monica

doi:10.1007/s10103-017-2284-9

Cited by 14 publications

(10 citation statements)

References 37 publications

(38 reference statements)

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“…Interestingly, several studies have shown the effectiveness of photobiomodulation in different clinical conditions , such as headache, low back pain carpal tunnel syndrome, and temporomandibular joint dysfunction . Furthermore, the analgesic effect of low‐intensity infrared photobiomodulation radiation has been demonstrated in neuropathy experimental models, osteoarthritis, persistent inflammatory pain, and postoperative pain . However, this is the first time in which the low‐intensity LED effect was demonstrated in the chronic pain produced by the IR procedure in mice, which reinforces the translational nature of this study.…”

Section: Discussionsupporting

confidence: 72%

Low‐Intensity Photobiomodulation Decreases Neuropathic Pain in Paw Ischemia‐Reperfusion and Spared Nervus Ischiadicus Injury Experimental Models

et al. 2019

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Background There is a wide range of animal models available today for studying chronic pain associated with a variety of etiologies and an extensive list of clinical manifestations of peripheral neuropathies. Photobiomodulation is a new tool for the treatment of pain in a convenient, noninvasive way. Objective The aim of this work is to elucidate the effects of infrared light‐emitting diodes (LEDs) on behavioral responses to nociceptive stimuli in chronic pain models. Methods Forty‐eight Swiss male mice weighing 25 to 35 g were used. Two chronic pain models, ischemia‐reperfusion (IR) and spared spinal nerve injury, were performed and then treated with infrared LED irradiation (390 mW, 890 nm, 17.3 mW/cm2, 20.8 J/cm2, for 20 minutes). The behavioral tests used were a mechanical hypersensitivity test von Frey test) and a cold allodynia test (acetone test). Results The results showed that, in the IR model, the infrared LED had a significant effect on mechanical stimulation and cold allodynia on every day of treatment. In the spared nerve injury model, an analgesic effect was observed on every treatment day (when started on the 3rd and 7th days after the surgery). In both models, the effect was abolished when the treatment was interrupted. Conclusions These findings suggest that photobiomodulation therapy may be a useful adjunct treatment for chronic pain.

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Section: Discussionsupporting

confidence: 72%

Low‐Intensity Photobiomodulation Decreases Neuropathic Pain in Paw Ischemia‐Reperfusion and Spared Nervus Ischiadicus Injury Experimental Models

et al. 2019

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“…Other studies also observed late effects of PBM: day 9, day 14 and after 6 weeks . The PBM may decrease pain and inflammation caused by the joint injury, with consequent sensitization reduction . The analgesic effect of laser therapy is controversial: systematic review and meta‐analysis report that laser treatment has neither early nor later benefits in reducing pain or improving function in patients with knee OA .…”

Section: Discussionmentioning

confidence: 99%

“…However, one of the possible explanations for pain relief is the resolution of the inflammatory process, resulting in decreased edema and synovitis. Another possibility is that the PBM may affect the conduction rate and the nervous fiber action potential amplitude . Although cartilage loss is not directly related to pain, it is suggested that the regeneration of the cartilage after PBM is responsible for the relief of pain in this process …”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

Yamada

Bobinski

Martins

et al. 2019

Journal of Biophotonics

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Knee osteoarthritis (OA) is a chronic disease that causes pain and gradual degeneration of the articular cartilage. In this study, MIA‐induced OA knee model was used in rats to test the effects of the photobiomodulation therapy (PBM). We analyzed the inflammatory process (pain and cytokine levels), and its influence on the oxidative stress and antioxidant capacity. Knee OA was induced by monosodium iodoacetate (MIA) intra‐articular injection (1.5 mg/50 μL) and the rats were treated with eight sessions of PBM 3 days/week (904 nm, 6 or 18 J/cm2). For each animal, mechanical and cold hyperalgesia and spontaneous pain were evaluated; biological analyses were performed in blood serum, intra‐articular lavage, knee structures, spinal cord and brainstem. Cytokine assays were performed in knee, spinal cord and brainstem samples. The effects of the 18 J/cm2 dose of PBM were promising in reducing pain and neutrophil activity in knee samples, together with reducing oxidative stress damage in blood serum and spinal cord samples. PBM improved the antioxidant capacity in blood serum and brainstem, and decreased the knee pro‐inflammatory cytokine levels. Our study demonstrated that PBM decreased oxidative damage, inflammation and pain. Therefore, this therapy could be an important tool in the treatment of knee OA.

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“…36 Interestingly, a study reported that a 808 nm near infrared laser generated the antianalgesic effect from 5 to 30 min after treatment and vanished after 60 min. 37 Kim and Kim conducted a 3-week treatment using an 850 nm galliumaluminum-arsenide laser, resulting in the weight-bearing difference, PWMT, and PWL significantly reversed, and the serum levels of TNF-a, IL-1b, and IL-6 also decreased in a MIA-induced KOA model. 29 These results indicated that different parameters of laser intervention have differ-ent effects on MIA-induced KOA pain.…”

Section: Effects Of Laser Moxibustion On Mia-induced Koamentioning

confidence: 99%

The Effects of Laser Moxibustion on Knee Osteoarthritis Pain in Rats

Wei

et al. 2020

Photobiomodulation, Photomedicine, and Laser Surgery

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Background: Although chronic pain affects the quality of life of patients with osteoarthritis, current medical treatments are either ineffective or have long-term side effects. Recently, low-intensity laser irradiation of corresponding acupoints was demonstrated to alleviate pain. Objective: The aim of the present study was to investigate the effects of 10.6 lm laser moxibustion on a monosodium iodoacetate (MIA)-induced knee osteoarthritis pain model. Methods: Thirty-two rats were randomly assigned to four groups: Saline, MIA, MIA+Laser, and MIA+Sham Laser. The 10.6 lm laser was used to irradiate the ST35 for 10 min once a day for a total of seven applications. The paw withdrawal mechanical threshold and weight-bearing difference were performed to evaluate the analgesic effects of laser moxibustion. At the end of the experiment on days 28, the joint histology, the levels of metalloproteinases-13 (MMP-13) in the cartilage, and TNF-a, IL-1b, and IL-6 in the synovial membrane were measured to determine the chondroprotection and anti-inflammatory effect of laser moxibustion. Results: Early laser moxibustion significantly reversed the MIA-induced mechanical hyperalgesia and weightbearing difference, especially on the 28th day (p < 0.001). Moreover, laser moxibustion prevented the articular pathological lesions and cartilage destruction on days 28 (p < 0.01). Remarkably, the levels of cartilage MMP-13, and synovial TNF-a, IL-1b, and IL-6 also decreased on day 28 (p < 0.05) after the early treatment of laser moxibustion. Conclusions: 10.6 lm laser moxibustion may have long-lasting analgesic, anti-inflammatory, and chondroprotection effects, suggesting that it may emerge as a potential therapeutic strategy for the chronic pain treatment of osteoarthritis.

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Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat

Cited by 14 publications

References 37 publications

Low‐Intensity Photobiomodulation Decreases Neuropathic Pain in Paw Ischemia‐Reperfusion and Spared Nervus Ischiadicus Injury Experimental Models

Low‐Intensity Photobiomodulation Decreases Neuropathic Pain in Paw Ischemia‐Reperfusion and Spared Nervus Ischiadicus Injury Experimental Models

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

The Effects of Laser Moxibustion on Knee Osteoarthritis Pain in Rats

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