Photobiomodulation on critical bone defects of rat calvaria: a systematic review

Brassolatti, Patrícia; Andrade, Ana Luiza Dias Leite de; Bossini, Paulo Sérgio; Orth, Daiana Laurenci; Duarte, Fernanda Oliveira; Souza, Ana Beatriz dos Anjos; Parizotto, Nivaldo Antônio; Aníbal, Fernanda de Freitas

doi:10.1007/s10103-018-2653-z

Cited by 9 publications

(10 citation statements)

References 26 publications

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“…Furthermore, Table 4 demonstrated that the use infrared wavelength is a consensus among authors (the only exception is the study of Asanami, et al 37 ), once it is widely known that infrared range is more effective to stimulate bone because longer wavelengths reach deeper tissues 62,63 . A systematic review published by Brassolatti, et al 64 also demonstrated that the infrared wavelengths are the most common ones used when PBM is applied with the purpose of healing bone tissue.…”

Section: Discussionmentioning

confidence: 99%

Bone substitutes and photobiomodulation in bone regeneration: A systematic review in animal experimental studies

Magri

Parisi

Andrade

et al. 2021

J Biomedical Materials Res

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In general, bone fractures are able of healing by itself. However, in critical situations such as large bone defects, poor blood supply or even infections, the biological capacity of repair can be impaired, resulting in a delay of the consolidation process or even in non‐union fractures. Thus, technologies able of improving the process of bone regeneration are of high demand. In this context, ceramic biomaterials‐based bone substitutes and photobiomodulation (PBM) have been emerging as promising alternatives. Thus, the present study performed a systematic review targeting to analyze studies in the literature which investigated the effects of the association of ceramic based bone substitutes and PBM in the process of bone healing using animal models of bone defects. The search was conducted from March and April of 2019 in PubMed, Web of Science and Scopus databases. After the eligibility analyses, 16 studies were included in this review. The results showed that the most common material used was hydroxyapatite (HA) followed by Biosilicate associated with infrared PBM. Furthermore, 75% of the studies demonstrated positive effects to stimulate bone regeneration from association of ceramic biomaterials and PBM. All studies used low‐level laser therapy (LLLT) device and the most studies used LLLT infrared. The evidence synthesis was moderate for all experimental studies for the variable histological analysis demonstrating the efficacy of techniques on the process of bone repair stimulation. In conclusion, this review demonstrates that the association of ceramic biomaterials and PBM presented positive effects for bone repair in experimental models of bone defects.

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Section: Discussionmentioning

confidence: 99%

Bone substitutes and photobiomodulation in bone regeneration: A systematic review in animal experimental studies

Magri

Parisi

Andrade

et al. 2021

J Biomedical Materials Res

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“…However, comparing the different doses, application protocols and experimental models between such studies is difficult 24 . According to a review by Brassolatti, et al 39 (2018), the use of both red and infrared wavelengths in lasers investigated the promotion of osteogenic effects in defects considered critical, and suggests that the infrared wavelength in lasers is better due to their wavelength promoting a greater penetration depth in the tissue being treated. However, according to Tani, et.…”

Section: Discussionmentioning

confidence: 99%

The influence of LLLT applied on applied on calvarial defect in rats under effect of cigarette smoke

et al. 2019

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Objective: Considering the global public health problem of smoking, which can negatively influence bone tissue repair, the aim of this study is to analyze the influence of photobiomodulation therapy (PBM) on calvaria defects created surgically in specimens under the effect of cigarette smoke and analyzed with use of histomorphometric and immunohistochemistry techniques.Methodology: Calvaria defects 4.1 mm in diameter were surgically created in the calvaria of 90-day-old rats (n=60) that were randomly divided into 4 experimental groups containing 15 animals each: control group (C), smoking group (S), laser group (L), and smoke associated with laser group (S+L).The animals were subjected to surgery for calvaria defects and underwent PBM, being evaluated at 21, 45, and 60 days post-surgery. The specimens were then processed for histomorphometric and immunohistochemistry analyses. The area of bone neoformation (ABN), percentage of bone neoformation (PBNF), and the remaining distance between the edges of the defects (D) were analyzed histometrically. Quantitative analysis of the TRAP immunolabeled cells was also performed. The data were subjected to analysis of variance (ANOVA) in conjunction with Tukey's test to verify the statistical differences between groups (p<0.05). Results: The smoking group showed less ABN compared to the other experimental groups in all periods, and it also showed more D at 21 days compared to the remaining groups and at 45 days compared to the laser group. The smoking group showed a lower PNBF compared to the laser group in all experimental periods and compared to smoking combined with LLLT group at 21 days. Conclusions:PBM acted on bone biomodulation, thus stimulating new bone formation and compensating for the negative factor of smoking, which can be used as a supportive therapy during bone repair processes.

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“…Não há consenso na literatura quanto à seleção da maioria dos parâmetros de FBM para o tratamento de defeitos ósseos (Santinoni et al, 2017;Brassolatti et al, 2018;Escudero et al, 2019). Considerando os parâmetros de forma isolada, Os efeitos da FBM nas CTMs têm sido recentemente explorados e observa-se que essas células são estimuladas por diferentes vias de sinalização quando expostas à irradiação com doses na faixa entre 2 e 5 J/cm 2 (Garcia et al, 2014;Marques et al, 2016;Han et al, 2019;).…”

Section: Fbm No Reparo E Regeneração Do Tecido óSseounclassified

“…Neste sentido, a FBM vem demonstrando ser uma alternativa terapêutica eficaz no tratamento de defeitos ósseos em pacientes diabéticos, apesar da falta de consenso sobre o protocolo ideal a ser utilizado (Akyol;Güngörmüş, 2010;Brassolatti et al, 2018;Zare et al, 2020).…”

Section: Fbm No Reparo E Regeneração Do Tecido óSseounclassified

“…Brassolatti et al (2018) consideram a escolha do comprimento de onda o fator mais relevante por estar relacionado diretamente com o tipo e a profundidade de uma lesão.Quanto maior o comprimento de onda, maior a profundidade de penetração no tecido.Assim, o comprimento de onda infravermelho (735-905 nm) mostrou ser o mais eficiente para lesões ósseas(Brassolati et al 2018). Isso vai ao encontro do observado porEscudero et al (2019) que evidenciaram que, além do laser de gálioalumínio-arseneto (GaAIAs) ser o mais utilizado, protocolos com comprimento de onda de 830nm e densidade de energia de 4 J/cm 2 resultaram em efeitos positivos no reparo de defeitos ósseos.…”

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Efeito da terapia de fotobiomodulação na diferenciação osteoblástica de células-tronco mesenquimais derivadas da medula óssea de ratos diabéticos

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Photobiomodulation on critical bone defects of rat calvaria: a systematic review

Cited by 9 publications

References 26 publications

Bone substitutes and photobiomodulation in bone regeneration: A systematic review in animal experimental studies

Bone substitutes and photobiomodulation in bone regeneration: A systematic review in animal experimental studies

The influence of LLLT applied on applied on calvarial defect in rats under effect of cigarette smoke

Efeito da terapia de fotobiomodulação na diferenciação osteoblástica de células-tronco mesenquimais derivadas da medula óssea de ratos diabéticos

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