Photobiomodulation in Sciatic Nerve Crush Injuries in Rodents: A Systematic Review of the Literature and Perspectives for Clinical Treatment

Sasso, Letícia Lemes; Souza, Luana Gabriel Gabriel de; Girasol, Carlos Eduardo; Marcolino, Alexandre Márcio; Guirro, Rinaldo Roberto de Jesus; Barbosa, Rafael Inácio

doi:10.34172/jlms.2020.54

Cited by 16 publications

(6 citation statements)

References 34 publications

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“…equals 5 Joules/cm 2 [33,34] . This was coinciding with many studies concerned with biostimulation and nerve regeneration that showed optimum results at the power off 0.5W and should not exceed it [35][36][37] .…”

Section: Discussionsupporting

confidence: 76%

Effect of Low Level Laser Therapy (LLLT) as an adjunct to Platelet Rich Fibrin (PRF) on sciatic nerve regeneration in rat model

Dakrory

Amin

2022

Egyptian Dental Journal

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Peripheral nerve injury (PNI) is a challenging injury in which healing relies on many factors. End-to-end neurorrhaphy (EEN) is the gold standard technique used in management of these injuries. Platelet rich fibrin (PRF) and low level laser therapy (LLLT) have the ability to enhance nerve regeneration after neurorrhaphy. The aim of this study is to evaluate the effect of LLLT as an adjunct to PRF use after end-to-end neurorrhaphy on sciatic nerve regeneration in rat model. Material and methods:This double-blind randomized study was performed on 20 Albino Wistar rats in the animal house of Misr University for Science and Technology. Animals were divided into two groups; group I in which nerve repair was performed using EEN with PRF membrane, in group II the same treatment was performed in addition to intraoperative application of LLLT diode laser. Within each group, animals were divided into two subgroups where rats were sacrificed after one and three weeks follow-up period. Assessment was performed using electromyography measurements and area percent evaluation of S100 protein immunostain at one and three weeks follow-up periods.Results: Comparison showed that electromyography measurements improved in group II more than group I with significant difference in the first week follow-up period. At three weeks follow-up period group II showed enhanced values than group I but with no significance. Histologic examination showed more enhanced regeneration with group II at both follow-up periods with significant difference. Conclusion:Application of LLLT enhances peripheral nerve regeneration of sciatic nerve in rat model (3172)

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Section: Discussionsupporting

confidence: 76%

Effect of Low Level Laser Therapy (LLLT) as an adjunct to Platelet Rich Fibrin (PRF) on sciatic nerve regeneration in rat model

Dakrory

Amin

2022

Egyptian Dental Journal

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“…The score 2 was observed for only one day. This is not true for the sciatic nerve, where the recovery is observed after 3 weeks [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Bee Venom and Its Major Components on Facial Nerve Injury Induced in Mice

et al. 2023

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Peripheral nerve injury (PNI) is a health problem that affects many people worldwide. This study is the first to evaluate the potential effect of bee venom (BV) and its major components in a model of PNI in the mouse. For that, the BV used in this study was analyzed using UHPLC. All animals underwent a distal section-suture of facial nerve branches, and they were randomly divided into five groups. Group 1: injured facial nerve branches without any treatment. Group 2: the facial nerve branches were injured, and the normal saline was injected similarly as in the BV-treated group. Group 3: injured facial nerve branches with local injections of BV solution. Group 4: injured facial nerve branches with local injections of a mixture of PLA2 and melittin. Group 5: injured facial nerve branches with local injection of betamethasone. The treatment was performed three times a week for 4 weeks. The animals were submitted to functional analysis (observation of whisker movement and quantification of nasal deviation). The vibrissae muscle re-innervation was evaluated by retrograde labeling of facial motoneurons in all experimental groups. UHPLC data showed 76.90 ± 0.13%, 11.73 ± 0.13%, and 2.01 ± 0.01%, respectively, for melittin, phospholipase A2, and apamin in the studied BV sample. The obtained results showed that BV treatment was more potent than the mixture of PLA2 and melittin or betamethasone in behavioral recovery. The whisker movement occurred faster in BV-treated mice than in the other groups, with a complete disappearance of nasal deviation two weeks after surgery. Morphologically, a normal fluorogold labeling of the facial motoneurons was restored 4 weeks after surgery in the BV-treated group, but no such restoration was ever observed in other groups. Our findings indicate the potential of the use of BV injections to enhance appropriate functional and neuronal outcomes after PNI.

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“…The effects of PBM therapy have been also widely reported after injury of the sciatic nerve (19,20). Sciatic functional index (SFI) and range of motion (ROM) analyses have revealed an acceleration of functional nerve recovery following PBM treatment (830 nm) at 8 J/cm 2 14 days after surgery (21).…”

Section: Behavioral Effect Of Irmentioning

confidence: 98%

Efficacy of LED Photobiomodulation for Functional and Axonal Regeneration After Facial Nerve Section-Suture

et al. 2022

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Facial nerve damage can lead to partial or total facial nerve palsy. Photobiomodulation has been reported to improve and accelerate functional recovery following peripheral nerve lesion, depending on the type of lesion and the light exposure parameters used. The aim of this study was to investigate the effects of infrared exposure on functional and axonal regeneration after section-suture of the distal branches of the facial nerve: the buccal and marginal mandibular branches and the distal pes. The animals underwent surgery and were irradiated with infrared light at 850 nm twice daily from day 1 to day 16. The recovery of facial function was then studied at both the behavioral and morphological levels. Behavioral analyses were performed by videoscoring with a high-speed camera and using various devices to assess the recovery of whisker movement on the lesioned side from day 1 to day 30. We also assessed nasal deviation toward the intact side and the ability to close the ipsilateral eyelid completely from day 1 to day 38 and from day 1 to day 50, respectively. For morphological analyses, we assessed the re-establishment of facial motoneuron labeling with Fluorogold®, an immunofluorescent retrograde marker of axonal transport injected into the vibrissae, on D10, D14 and D30. We found that whisker movements recovery was significantly faster in treated than in control mice. A complete disappearance of nasal deviation was observed at 2 weeks in infrared-treated lesioned mice and at 5 weeks in controls. Complete eyelid closure was observed 3 weeks after surgery in treated animals and 6 weeks after surgery in controls. Finally, normal fluorogold labeling of the facial nuclei complex was restored 30 days after surgery in the treated animals, but no such restoration was ever observed in control animals. In conclusion, our data show that IR treatment at a distal site has a significant positive effect on facial nerve recovery. These findings pave the way for the clinical use of infrared photobiomodulation in patients with nerve lesions.

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Photobiomodulation in Sciatic Nerve Crush Injuries in Rodents: A Systematic Review of the Literature and Perspectives for Clinical Treatment

Cited by 16 publications

References 34 publications

Effect of Low Level Laser Therapy (LLLT) as an adjunct to Platelet Rich Fibrin (PRF) on sciatic nerve regeneration in rat model

Effect of Low Level Laser Therapy (LLLT) as an adjunct to Platelet Rich Fibrin (PRF) on sciatic nerve regeneration in rat model

Beneficial Effect of Bee Venom and Its Major Components on Facial Nerve Injury Induced in Mice

Efficacy of LED Photobiomodulation for Functional and Axonal Regeneration After Facial Nerve Section-Suture

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