Photoallergic dermatitis induced by diltiazem

Ramírez, A.; Pérez-Pérez, L.; Fernández‐Redondo, Virginia; Toribio, Jaime

doi:10.1111/j.1600-0536.2007.00967.x

Cited by 9 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the group of calcium channel blockers, amlodipine and nifedipine have been found to cause photodistributed facial telangiectasia [14] and diltiazem photodistributed hyperpigmentation, photosensitivity and photoallergic dermatitis [15].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Drug Use and Risk of Actinic Keratosis: A Case-Control Study

Warszawik-Hendzel

Olszewska

Rakowska

et al. 2020

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Introduction: Actinic keratosis (AK) is a precancerous skin lesion. Currently, many experts treat actinic keratosis as squamous cell carcinoma in situ. It is well established that exposure of the skin to ultraviolet radiation is a major risk factor for the development of actinic keratosis. Some studies suggest an association between keratinocyte cancers and photosensitizing cardiovascular drugs. The aim of this study was to establish an association between cardiovascular drug use and the presence of AK. Methods: A total of 400 patients were enrolled into the study (200 with AK; 200 healthy persons in the control group). The group of patients with AK consisted of 106 women and 94 men (mean age 71 years). The control group included 102 women and 98 men (mean age 69 years). An analysis of the risk factors for developing actinic keratosis was performed in all patients with AK on the basis of a detailed, standardized interview. Results: The statistical analysis showed that features independently associated with increased risk of AK included: age [ 80 years (OR 4.14; 95% CI 2.4-7.3), positive cancer history (OR 1.94; 95% CI 1.0-3.6), positive history of sunburns when \ 18 years old (OR 2.18; 95% CI 1.3-3.7) and taking angiotensin-converting enzyme inhibitors (OR 2.28; 95% CI 1.2-4.3), angiotensin receptor AT 1 blockers (OR 2.90; 95% CI 1.1-7.9) and calcium channel blockers (OR 2.4; 95% CI 1.0-5.3). Conclusion: In conclusion, our study presented an association between cardiovascular drug use and the risk of developing AK.

show abstract

Section: Introductionmentioning

confidence: 99%

Cardiovascular Drug Use and Risk of Actinic Keratosis: A Case-Control Study

Warszawik-Hendzel

Olszewska

Rakowska

et al. 2020

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

show abstract

“…Allergy and photocontact allergy (2) to oral diltiazem have been reported and confirmed by patch testing (3). Diltiazem, a calcium channel antagonist, is both a systemic and a contact sensitizer.…”

Section: Discussionmentioning

confidence: 94%

“…Diltiazem, a calcium channel antagonist, is both a systemic and a contact sensitizer. A spectrum of cutaneous reactions, including erythema multiforme, erythroderma, exfoliative dermatitis, pruritic exanthematous eruption, photosensitive erythroderma, acute generalized exanthematous pustulosis, and vasculitis, has been reported to be associated with diltiazem (2–4).…”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis caused by topical diltiazem

Wong

Horn

2010

Contact Dermatitis

View full text Add to dashboard Cite

“…Oral calcium channel blockers may induce a generalized cutaneous reaction (1), erythema, fever and angio‐edema (2), psoriasiform reaction (3), maculopapular reaction (4), photoallergic dermatitis (5), and reversible hyperpigmentation (6). In these cases, the patch test result is often positive when the reaction is induced by diltiazem, but more rarely with other calcium channel blockers (3).…”

Section: Discussionmentioning

confidence: 99%