Photoaging

Han, Aijun; Chien, Anna L.; Kang, Sewon

doi:10.1016/j.det.2014.03.015

Cited by 154 publications

(148 citation statements)

References 48 publications

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“…In particular, ultraviolet radiation A is responsible for increased production of reactive oxygen species (ROS) which cause oxidative damage to cellular components such as DNA, lipids, proteins and mitochondria. 3 Clinical manifestation of skin photoaging includes rhytids, coarse texture, loss of translucency, pigmentation heterogeneities, elastosis and reduced turgor correlated with elastin and collagen degradation, decreased dermal and epidermal thickness owing to dermal cell and fibroblast apoptosis, precancerous lesions, and skin cancer. 3 The first line of defense against photoaging remains skin protection during sun exposure.…”

Section: Introductionmentioning

confidence: 99%

“…3 Clinical manifestation of skin photoaging includes rhytids, coarse texture, loss of translucency, pigmentation heterogeneities, elastosis and reduced turgor correlated with elastin and collagen degradation, decreased dermal and epidermal thickness owing to dermal cell and fibroblast apoptosis, precancerous lesions, and skin cancer. 3 The first line of defense against photoaging remains skin protection during sun exposure. Symptomatic treatments include topical administration of retinoids, neuro-modulators, dermal fillers and the use of visible light devices.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Facial skin rejuvenation by autologous dermal microfat transfer in photoaged patients: Clinical evaluation and skin surface digital profilometry analysis

Trivisonno¹,

Rossi²,

Monti³

et al. 2017

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Please cite this article as: Trivisonno, A.; Rossi, A.; Monti, M.; Di Nunno, D.; Desouches, C.; Cannistra, C.; Toietta, G. Facial skin rejuvenation by autologous dermal microfat transfer in photoaged patients: Clinical evaluation and skin surface digital profilometry analysis. Journal of Plastic Reconstructive and Aesthetic Surgery 2017, 70, 1118-1128. DOI: 10.1016/j.bjps.2017 http://www.sciencedirect.com/science/article/pii/S1748681517301559 M A N U S C R I P T A C C E P T E D M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 2 SUMMARYCumulative, long-term exposure to solar ultraviolet radiation promotes premature skin aging characterized by wrinkle formation and reduced skin elasticity. In this study, we assessed whether microfat transfer could improve dermal and subcutaneous tissue thickness loss associated with photoaging. Twenty one patients affected by facial photoaging (photodamage grade II-IV; age range 35-62 years; 19 females, 2 males; all of Caucasian origin) were treated using minimally-invasive autologous dermal white fat transfer harvested with a recently designed microcannula. The results were determined by clinical assessment, patient self-evaluation and quantified by the Antera 3D ® dermal digital device for non-invasive, objective, reliable and accurate assessment of facial skin texture, color and wrinkle characteristics. Compared with the pretreatment condition, the increment in soft tissue volume and improvement in skin quality and texture was assessed by a dermatologist after treatment. In addition, instrumental evaluation by digital skin profilometry of the treated areas revealed:a 41% reduction in average wrinkle depth (7.29 ± 1.04 x 10 -2 mm pre-treatment vs. 4.31 ± 1.16 x 10 -2 mm at 90 days post-treatment; p < 0.001), improved skin texture, more homogeneous and uniform skin color and declined facial hemoglobin and melanin concentrations. The majority of patients (above 90%) reported improvements in self-perception. No significant complications were reported throughout the study. In conclusion, by using digital profilometry analysis as an objective and innovative tool to determine the outcome of treatment, we demonstrated that autologous microfat transfer is a safe and well-tolerated procedure with measurable beneficial effects on facial skin aging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Facial skin rejuvenation by autologous dermal microfat transfer in photoaged patients: Clinical evaluation and skin surface digital profilometry analysis

Trivisonno¹,

Rossi²,

Monti³

et al. 2017

Journal of Plastic, Reconstructive & Aesthetic Surgery

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“…[9][10][11] The skin shows hypertrophic features with deep wrinkles, leathery appearance, dark/light pigmentation, sallowness, premalignant lesions, irregular dryness, and lentigines. [12] Other signs of aging include elastosis (a coarse, yellow, cobblestoned effect is on the skin) and actinic purpura (easy bruising corresponding to vascular wall fragility in dermis). [13] Figure 1 outlines the possible molecular mechanism of skin aging that takes place in the skin.…”

Section: Clinical Manifestation Of Photoagingmentioning

confidence: 99%

Untitled

Garg

2017

IJGP

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Skin ageing is a complex multifactorial process occurring in all living beings. It generally comprises two independent and distinct processes, i.e., intrinsic, age-dependent or chronological aging and premature aging, or photoaging which is the result of undue exposure of the skin to ultraviolet (UV) radiations. Photoaging can be prevented or the effects of photoaging can be reduced by the use of certain anti-aging and anti-wrinkle agents. The extracellular matrix (ECM) which forms the outermost part of skin comprises fibroblasts and proteins such as collagen and elastin. Degradation of ECM is directly linked to skin aging and is responsible for the increase in activity of certain enzymes such as collagenase, elastase, and hyaluronidase (HYAL) that are involved in skin aging. With aging there is decrease in the levels of elastin, collagen, and hyaluronic acid which leads to loss of strength and flexibility of skin and appear as wrinkles on the skin. Further, the increase in the activity of collagenase, elastase, and HYAL is triggered by the high levels of reactive oxygen species produced when the skin is exposed to excessive UV radiations leading to skin aging. Today, in the age of modern science and advanced technology, although many techniques such as laser rejuvenation, plastic surgery, and lots of synthetic products such as sunscreen lotions, creams are available yet, there is a place for natural, herbal anti-aging cosmetics. Various botanical extracts have the power to reduce the appearance of skin aging and enhance the beauty of the skin. Medicinal plants have several phytoconstituents such as polyphenols, alkaloids, tannins, saponins, carotenoids, and terpenoids which possess antioxidant properties and can be used in treating the signs of aging. Some plants contain phenolic compounds which have free-radical scavenging property and can suppress aging. Some plants or their extracts possess several other constituents that may have the capability of inhibiting various enzyme such as HYAL, elastase, and matrix metalloproteinases enzyme that play a major role in skin aging. Some of them may possess the free radical scavenging or antioxidant property to fight against the signs of aging. This review focuses on the compilation of medicinal plants and natural compounds as anti-aging and anti-wrinkling agents along with their chemical constituents based on their possible molecular mechanism of action. The present review will facilitate the scientists working in this area for the development of new anti-aging and anti-wrinkle formulations with better efficiency and safety.

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“…Main signs of photoaging include fine and deep wrinkles, dyspigmentation, loss of skin tone and elasticity [2,4]. Several studies have demonstrated that the skin can be stimulated to correct aging/ photoaging alterations by the intradermal injection of biological substances able to induce a revitalization of the dermis.…”

Section: Introductionmentioning

confidence: 99%

“…The changes of photo-damage are superimposed on the changes caused by chronological aging and are responsible for most of the age-associated features of skin appearance [2,3].…”

Section: Introductionmentioning

confidence: 99%