Photoactivation Inducing Multifunctional Coupling of Fluorophore for Efficient Tumor Therapy In Situ

Abstract

Photoactivatable molecules, with high‐precision spatial and temporal control, have largely promoted bioimaging and phototherapy applications, particularly for fluorescent dyes. Here, we described the first photoactivatable sensor (BI) that can be triggered by broad excitation light (405‐660 nm), which further undergoes ISC (intersystem crossing) and HAT (H‐atom transfer) processes to the formation of superoxide anion radicals (O2−•) and carbon radicals. Particularly, the photoinduced gain of carbon‐centered radicals (BI•) allows for radical‐radical coupling to afford the combined crosslink product (BI‐BI), which would be oxidized in the presence of O2−• to produce an extended conjugate system with NIR emission (820 nm). Besides, the photochemically generated product (Cy‐BI) possesses ultra‐high PCE (photothermal conversion efficiency) up to 90.9%, which enables optimized potential for phototherapy. What's more, Western Blot assay revealed that both BI and the coresponding photoproduct Cy‐BI could efficiently inhibit the expression of CHK1, and the irradiation of BI and Cy‐BI further induced apoptosis and ultimately enhancing the phototherapeutic effects. Thus, the combination of cell cycle block inducing apoptosis, PDT (photodynamic therapy) and PTT (photothermal therapy) treatment significantly suppressed solid tumor in vivo antitumor efficacy explorations. This is a novel finding in developing photoactivatable molecules, as well as the broad applicability of photoimaging and phototherapy in tumor‐related areas.This article is protected by copyright. All rights reserved

NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma

“…The corresponding photothermal conversion efficiency of Mn@ Bi 2 Se 3 was calculated as ∼46.6% (Figure 2G), which was comparable to the effectiveness of other photothermal agents as stated in previous reports. 51,52 These findings underscore the remarkable capability of Mn@Bi 2 Se 3 in efficiently converting photon energy into thermal energy. We supposed that this may provide a thermodynamic environment conducive to enhancing the nanocatalytic activities.…”

Molecularly Engineered Near-Infrared Aggregation-Induced Emission Photosensitizer for In Situ-Activated Light Irradiation-Free Photodynamic Therapy

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