Photoactivated stereospecific cleavage of double-helical DNA by cobalt(III) complexes

Barton, Jacqueline K.; Raphael, Adrienne L.

doi:10.1021/ja00320a058

Cited by 365 publications

(144 citation statements)

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“…If scission occurs on one strand (nicking), the supercoils will relax to generate a slowermoving open circular form (Form II) (Barton and Raphael, 1984). As reported, many organic molecules interacting with DNA could bring scission of DNA stands, and a change of Form I to Form II could be observed after incubation with organic molecules (Kumar and Arunachalam, 2007;Yu et al, 2009).…”

mentioning

confidence: 89%

Cytotoxic Activities and DNA Binding Properties of 1-Methyl-7H-indeno[1,2-b]Quinolinium-7-(4-dimethylamino) Benzylidene Triflate

Wen

Wang

et al. 2012

DNA and Cell Biology

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The interaction of calf thymus DNA (ct-DNA) with a novel synthesized pyrazolo [1,5-a]indole compound 1-methyl-7H-indeno[1,2-b]quinolinium-7-(4-dimethylamino) benzylidene triflate (MIDBT) was extensively studied by various spectroscopic techniques, viscosity measurements, and gel electrophoresis. The UV-visible observation implied that the compound interacted with ct-DNA by two binding modes, intercalating into the DNA base pairs and attaching to the helix exterior of DNA. The results of the fluorescent quenching and viscosity measurements showed that MIDBT could intercalate into DNA base pairs deeply in a classical intercalative mode. Circular dichroism results showed that the binding of MIDBT shifted ct-DNA conformation from B to A at low concentrations. In the gel electrophoresis, the compound was found to promote the cleavage of plasmid pBR 322 DNA effectively. Furthermore, cytotoxic studies of this compound against eleven selected tumor cell lines have been done. The values of 50% cytotoxic concentration (IC 50 ) were in the range of 1.09-18.84 mM, exhibiting the potent cytotoxic properties.

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mentioning

confidence: 89%

Cytotoxic Activities and DNA Binding Properties of 1-Methyl-7H-indeno[1,2-b]Quinolinium-7-(4-dimethylamino) Benzylidene Triflate

Wen

Wang

et al. 2012

DNA and Cell Biology

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“…Substitution of a photoredox-active metal into the core of the tris(diphenylphenanthroline) unit leads also to a complex that both binds and, with photoactivation, cleaves at the altered conformation. 55 Both Co(III) polypyridyl and Rh(III) polypyridyl complexes have been shown to be potent photooxidants. Coupled to site-specific DNA binding, these metal complexes, with photoactivation, become conformationally selective DNA cleavage agents.…”

Section: Transition-metal Complexes As Shape-selective Probesmentioning

confidence: 99%

Metal–nucleic acid interactions

2014

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“…The sensitizing properties of various molecules, such as methylene blue, transition metal polypyridines and porphyrins have been extensively investigated in the last decades, aiming the development of efficient PDT drugs, imparting minima medical problems. [86][87][88][89][90][91][92][93][94][95][96][97] It is well established that the activity of such drugs is closely related to their ability to interact with cellular membranes and macromolecules, such as double-stranded DNA. For this reason, the interaction between the photosensitizing agents and DNA represents a relevant issue for investigation.…”

Section: Singlet Oxygen Generation and Dna Photocleavagementioning

confidence: 99%

“…86 The special sensitizer employed combines the remarkable redox and photochemical/photophysical properties of the porphyrins and ruthenium(II)-polypyridine compounds, in addition to their ability to strongly bind DNA via intercalation and outside association. [87][88][89][90][91] Analogously to its molecular components, the TRP species exhibits a potential usefulness in photodynamic therapy (PDT) applications. 92,93 From the supramolecular point of view, the peripheral ruthenium-polypyridine groups interact with the porphyrin center, promoting energy and electron transfer processes, and enhancing the photodynamic properties of the molecule.…”

Section: Singlet Oxygen Generation and Dna Photocleavagementioning

confidence: 99%

Molecular Materials and Devices: Developing New Functional Systems Based on the Coordination Chemistry Approach

Toma

2004

ChemInform

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Neste limiar da era nanotecnológica, o planejamento molecular dos materiais e os estudos de moléculas isoladas estão abrindo imensas possibilidades no emprego de sistemas moleculares em dispositivos eletrônicos e fotônicos, bem como em aplicações tecnológicas baseadas em propriedades de chaveamento ou reconhecimento molecular. Com esse escopo, os químicos inorgânicos em particular, podem aplicar com vantagens as estratégias proporcionadas pela química de coordenação, para construir nanomateriais funcionais que permitam a exploração das propriedades dos centros metálicos e das características dos ligantes presentes. A química de coordenação também oferece recursos eficientes na auto-montagem de nanoestruturas, baseadas na especificidade da interação metal-ligante e nas características estereoquímicas dos complexos. Diversos materiais moleculares gerados a partir de compostos inorgânicos e metal-orgânicos são focalizados neste artigo, com ênfase em novas porfirinas e porfirazinas supramoleculares, clusters e complexos metálicos. Tais sistemas também são enfocados sob o ponto de vista de suas aplicações em catálise, sensores e dispositivos moleculares.At the onset of the nanotechnology age, molecular designing of materials and single molecule studies are opening wide possibilities of using molecular systems in electronic and photonic devices, as well as in technological applications based on molecular switching or molecular recognition. In this sense, inorganic chemists are privileged by the possibility of using the basic strategies of coordination chemistry to build up functional supramolecular materials, conveying the remarkable chemical properties of the metal centers and the characteristics of the ancillary ligands. Coordination chemistry also provides effective self-assembly strategies based on specific metal-ligand affinity and stereochemistry. Several molecular based materials, derived from inorganic and metal-organic compounds are focused on this article, with emphasis on new supramolecular porphyrins and porphyrazines, metal-clusters and metal-polyimine complexes. Such systems are also discussed in terms of their applications in catalysis, sensors and molecular devices.

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Photoactivated stereospecific cleavage of double-helical DNA by cobalt(III) complexes

Cited by 365 publications

References 0 publications

Cytotoxic Activities and DNA Binding Properties of 1-Methyl-7H-indeno[1,2-b]Quinolinium-7-(4-dimethylamino) Benzylidene Triflate

Cytotoxic Activities and DNA Binding Properties of 1-Methyl-7H-indeno[1,2-b]Quinolinium-7-(4-dimethylamino) Benzylidene Triflate

Metal–nucleic acid interactions

Molecular Materials and Devices: Developing New Functional Systems Based on the Coordination Chemistry Approach

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