Photoactivated DNA Cleavage and Anticancer Activity of 3d Metal Complexes

Anti‐proliferative and Apoptotic Effects of Coordination Compounds of Zinc(II), Palladium(II), and Platinum(II) with Tridentate 4‐(6‐hydroxyphenyl)‐2,6‐di(thiazol‐2‐yl)pyridine

“…The optimized geometries suggest that molecule 1 contains a five-coordinated Zn atom chelated by one tridentate L and two chlorine atoms in a similar fashion (since the binding unit, 2,6-di(thiazol-2-yl)pyridine core is the same for its derivatives) with the analogous metal compounds of the 2,6di(thiazol-2-yl)pyridine derivatives. [30,32,35] The Pd(II) center in (2) and Pt(II) center in (3) adopt preferentially a distorted squareplanar structure that resembles the Pt(II) coordination compounds of 2,6-di(thiazol-2-yl)pyridine derivatives. [27] A.R.…”

“…The anticancer effects of metal-based compounds have been the subject of research for years. [1][2][3] After cisplatin was first approved, many platinum-based chemotherapy agents (carboplatin, oxaliplatin) have taken their place in first-line treatment regimens. The anticancer effect of cisplatin occurs when it binds to DNA.…”

Mechanistic Insights of Chelator Complexes with Essential Transition Metals: Antioxidant/Pro-Oxidant Activity and Applications in Medicine

“…Transition metal complexes that absorb light in the range suitable for photodynamic therapy (500-800 nm) have also been studied and shown to exhibit high cytotoxic activity against tumor cells of various histological origin [178,[191][192][193]. Similarly, complexes of anthraquinones with transition metal ions demonstrated higher cytotoxicity under the influence of light (IC50~2-11 µM) in comparison to only anthraquinones, and also low cytotoxicity under dark conditions (IC50 > 50 µM) [193].…”

Density Functional Theory-Guided Photo-Triggered Anticancer Activity of Curcumin-Based Zinc(II) Complexes

“…Cancer has been one of the most deadly diseases to treat until now. , The development of platinum-based anticancer drugs has made tremendous advances in the field of inorganic medicinal chemistry over the past few decades. − However, drug resistance and side effects of platinum-based drugs have restricted their premise. − Recently, photodynamic therapy (PDT) has evolved as a new therapeutic modality for curing cancer due to its huge cure gains and fewer side effects than chemotherapy and radiation therapy. − PDT uses light as a stimulus to activate a photosensitizer at the cancer site specifically without any harm to unexposed healthy tissues/cells. − For PDT application, the era of metal-based photosensitizers started recently. − In this regard, 4d and 5d metal-based photosensitizers are well studied due to their rich photophysics, photochemistry, and photostability. − However, there is now a paradigm shift toward 3d-metal-based photosensitizers as they are cost-effective and biocompatible. − …”