Photoactivatable metal organic framework for synergistic ferroptosis and photodynamic therapy using 450 nm laser

Ru(II) Phenanthroline-Based Oligothienyl Complexes as Phototherapy Agents

“…In addition, PDT can induce hypoxia as oxygen is consumed during irradiation. , Decreased generation of ROS limits damage to cancerous cells. To address this, there is motivation to develop light-triggered compounds that exploit oxygen-independent mechanisms for phototoxicity. − In this context, metal complexes such as Ru(II) polypyridyl systems have attracted considerable attention. ,,,− Judicious choice of ligand–metal combinations provides access to a variety of excited-state configurations with characteristic photophysical properties and reactivities. Strategies have included photorelease of bulky ligands to reveal phototoxic metals and/or ligands, ,,,,,− photocaging of chemotherapeutics and enzyme inhibitors, ,,,,,− …”

Nanoparticle-mediated synergistic anticancer effect of ferroptosis and photodynamic therapy: Novel insights and perspectives

“…designed a nanocarrier, HAFeR, for synergistic ferroptosis and PDT through encapsulating RSL3 and PSs in MOFs ( Fig. 6 A) [134] . The HAFeR specifically recognized overexpressed CD44 on the surface of tumor cells and was internalized by receptor-mediated endocytosis.…”

“…Reprinted with permission from Ref. [134] Copyright ©2023 ELSEVIER. (B) Synthetic route of p53/Ce6@ZF-T and its mediation of ferroptosis and PDT.…”

Nano theranostics involved in bladder cancer treatment

“…The intrinsic motility of these bacteria-driven microswimmers also promoted their binding to the mouse bladder wall and prolonged residence time in the bladder region, thus presenting new opportunities for the advancement of therapeutic platforms for bladder diseases. Chen et al [75] developed a nanocarrier, named HAFeR, which encapsulates PSs and RSL3 [inhibitor of glutathione peroxidase 4 (GPX4)] within MOFs, to achieve synergistic ferroptosis and PDT. This combination of apoptosis and ferroptosis was shown to exhibit strong toxicity to tumor cells, resulting in the effective eradication of tumors in tumor-bearing nude mice under laser light (Figure 8).…”