Photoacoustic/ultrasonic dual-mode imaging for monitoring angiogenesis and synovial erosion in rheumatoid arthritis

Wang, Zhen; Tong, Zhuangzhuang; Chen, Hongjiang; Nie, Guangshuai; Hu, Jia; Liu, Weiyang; Wang, Erqi; Yuan, Bo; Wang, Zhiyang; Hu, Jun

doi:10.1016/j.pacs.2023.100458

Cited by 9 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This can be connected to chronical in ammation which happens in recurrence of GA. With the development of in ammation, blood ow is slowed down with congestion and stagnation and the local oxygen saturation decreases 39 . A lasting low-grade in ammation leads to local hypoxia which has been demonstrated in other arthritis, such as posttraumatic OA animal 23 , RA animal 40 and RA patient 21 . This also supports the chronic in ammation progress in GA with the stimulus persists, which in this case is the accumulation of MSU crystal 1,4 .…”

Section: Discussionmentioning

confidence: 84%

Morphological and Physiological Monitoring of Gouty Arthritis Response to Low-Level Light Therapy

Gu,

Tan,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

Gouty arthritis (GA), induced by deposition of monosodium urate (MSU) crystals in joints, presents as intermittent episodes of acute inflammation along with chronic inflammation which can lead to irreversible erosive joint damage. Though widespread with a major negative impact on patients, there is no nonradiative and noninvasive method to monitor the inflammation quantitatively. By taking advantages of dual-wavelength optical-resolution photoacoustic microscopy (PAM), we monitored morphological and physiological features of vasculature in GA joint of rats in vivo. We showed that a hyperoxia period was followed by a hypoxia state in GA joints for the first time. Aiming at symptom control and recurrence prevention, we designed a ring-shape low-level light therapy (LLLT) device to treat the GA rats daily. We find that LLLT was able to reduce swelling, alleviate pain and accelerate dissolution of MSU crystals, which shortened the recovering time to half. Specifically, we observed that LLLT modulated the oxygen saturation level in joints with a less hyperoxia state at the beginning of GA and healed it to a normal level without experiencing hypoxia. Our result provided a non-invasive monitoring method and a drug-free treatment choice for GA, which revealed important aspects of the disease development and treatment mechanism.

show abstract

Section: Discussionmentioning

confidence: 84%

Morphological and Physiological Monitoring of Gouty Arthritis Response to Low-Level Light Therapy

Gu,

Tan,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The potential application landscape of PAI in systemic lupus erythematosus (SLE) is expansive. This imaging modality has proven its value in examining the vasculature [71,85], joints [132,133], and skin injuries [71,83,134], providing a range of insights into the depth and breadth of vascular structural abnormalities, arthritic inflammation, and skin damage. Given the autoimmune nature of SLE, characterized by vascular inflammation similar to psoriasis, PAI assists in observing changes in vascular structure.…”

Section: Pai Of Some Other Skin Diseasesmentioning

confidence: 99%

Photoacoustic Imaging of Human Skin for Accurate Diagnosis and Treatment Guidance

Ying,

Zhang,

Lin

2024

Optics

View full text Add to dashboard Cite

Photoacoustic imaging (PAI) is a cutting-edge biomedical imaging modality, providing detailed anatomical and functional information about the area beneath the skin surface. Its light energy deposition is such that PAI typically provides clear images of the skin with high signal-to-noise ratios. Specifically, the rich optical contrast of PAI allows biological information related to lesion growth, malignancy, treatment response, and prognosis to be seen. Given its significant advantages and emerging role in imaging skin lesions, we summarize and comment on representative studies of skin PAI, such as the guidance of skin cancer biopsies and surgical excisions, and the accurate diagnosis of psoriasis. We conclude with our insights about the clinical significance of skin PAI, showing how its use to identify biological characteristics in lesion microenvironments allows early diagnosis and prognosis of disease.

show abstract

“…Wang et al proposed a microscopic-based PA/US system for joint evaluation. The system used a 532 nm laser wavelength and a central frequency of 25 MHz to image the mouse knee joint (Wang et al, 2023a). The results of coaxial dual-modal imaging showed that the US can effectively visualize the synovial erosion area as a hypoechoic region within the tibiofemoral tendon-tibia-femur (TTF) complex.…”

Section: Preclinical Imagingmentioning

confidence: 99%

Dual-modal photoacoustic and ultrasound imaging: from preclinical to clinical applications

Nyayapathi,

Zheng,

Zhou

et al. 2024

Front. Photon.

View full text Add to dashboard Cite

Photoacoustic imaging is a novel biomedical imaging modality that has emerged over the recent decades. Due to the conversion of optical energy into the acoustic wave, photoacoustic imaging offers high-resolution imaging in depth beyond the optical diffusion limit. Photoacoustic imaging is frequently used in conjunction with ultrasound as a hybrid modality. The combination enables the acquisition of both optical and acoustic contrasts of tissue, providing functional, structural, molecular, and vascular information within the same field of view. In this review, we first described the principles of various photoacoustic and ultrasound imaging techniques and then classified the dual-modal imaging systems based on their preclinical and clinical imaging applications. The advantages of dual-modal imaging were thoroughly analyzed. Finally, the review ends with a critical discussion of existing developments and a look toward the future.

show abstract

Photoacoustic/ultrasonic dual-mode imaging for monitoring angiogenesis and synovial erosion in rheumatoid arthritis

Cited by 9 publications

References 52 publications

Morphological and Physiological Monitoring of Gouty Arthritis Response to Low-Level Light Therapy

Morphological and Physiological Monitoring of Gouty Arthritis Response to Low-Level Light Therapy

Photoacoustic Imaging of Human Skin for Accurate Diagnosis and Treatment Guidance

Dual-modal photoacoustic and ultrasound imaging: from preclinical to clinical applications

Contact Info

Product

Resources

About