Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain

Wang, Yiwen; Xie, Xueyi; Wang, Xueding; Ku, Geng; Gill, Kelly L.; O’Neal, D. Patrick; Stoica, George; Wang, Lihong V.

doi:10.1021/nl049126a

Cited by 439 publications

(350 citation statements)

References 16 publications

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“…S3). It has been demon- strated that a variety of gold nanocolloids are already entering in vivo clinical trials (19,(29)(30)(31)(32)(33). Among them, Au nanorods present particularly good optical absorption in the near-infrared region, tunable by changing the aspect ratio.…”

Section: B and Dmentioning

confidence: 99%

“…It has been shown that PAT can depict subsurface tissue structures and functional changes noninvasively with resolution up to 100 m (14, 15). Like other optical modalities, PAT is highly sensitive in mapping and quantifying the dynamic distribution of optical contrast agents such as metallic nanocolloids and organic dyes (16)(17)(18)(19)27).In the present work, we have fabricated a composite-material nanoparticle, which we call ''nanowonton.'' The nanowonton has a Co core and an Au thin-film coating and is a construct similar to the Chinese eatable called the wonton (see Fig.…”

mentioning

confidence: 99%

“…The incorporation of MRI and PAT into a single probe offers the unique possibility of combining the complementary strategies of contrastbased volume imaging and edge detection. Our nanoconstruct consists of zero-valence ferromagnetic cobalt (Co) particles (8) with a gold (Au) coating for biocompatibility and a unique shape rendering increased optical absorption over a broad range of frequencies (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). This research theme follows the rapid developments in nanotechnology, diagnostic radiology, and targeted molecular imaging (20), whereby nanoparticulate contrast agents, with the desirable properties of high chemical specificity, biocompatibility, and a reasonable half-life, are administered within a specific region of interest.…”

mentioning

confidence: 99%

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Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

Bouchard

Anwar

Liu

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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171

127

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Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.dual-modality imaging ͉ ferromagnetic nanoparticle ͉ molecular imaging ͉ MRI contrast ͉ photoacoustic tomography W e have synthesized nanoparticles for dual-modality (1-7)MRI and photoacoustic tomography (PAT). The incorporation of MRI and PAT into a single probe offers the unique possibility of combining the complementary strategies of contrastbased volume imaging and edge detection. Our nanoconstruct consists of zero-valence ferromagnetic cobalt (Co) particles (8) with a gold (Au) coating for biocompatibility and a unique shape rendering increased optical absorption over a broad range of frequencies (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). This research theme follows the rapid developments in nanotechnology, diagnostic radiology, and targeted molecular imaging (20), whereby nanoparticulate contrast agents, with the desirable properties of high chemical specificity, biocompatibility, and a reasonable half-life, are administered within a specific region of interest. In nanoparticle-based imaging studies, higher particle concentrations lead to better signal-to-noise contrasts, but this also poses a tradeoff with the toxicity. Therefore, one of the most important parameters when developing particle-based contrast is the safest and lowest nanoparticle concentration that offers sufficient contrast sensitivity.In MRI, magnetic materials such as gadolinium chelates and magnetic nanoparticles are often used (21-23) to enhance image contrast. The magnetic nanoparticles are passivated by biocompatible coatings such as dextrin, citrate, polystyrene/divinylbenzene, and elemental gold. These coatings also detoxify the particles, resulting in enhanced lifetimes in vivo. Typical examples of magnetic nanoparticulate core-shell configurations include magnetitedextrin, magnetite-silica (24) and iron-gold (25).Laser-based PAT (9-19) is a hybrid imaging modality [see supporting information (SI) Fig. S1]. It uses a pulsed laser source to illuminate a biological sample. Light absorption by the tissue results in a transient temperature rise on the order of 10 mK. The rapid thermoelastic expansion excites ultrasonic waves that are measured by using broadband ultrasonic transducers conformally arranged around the sample. Finally, a modif...

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Section: B and Dmentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

Bouchard

Anwar

Liu

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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171

127

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“…Due to their unique physicochemical properties, gold nanorods (Au-NRs) are being increasingly utilized in consumer and medical applications, including photothermal therapy, bioimaging, drug delivery, and site specific catalysis [1][2][3]. Specifically, these distinctive nanogold parameters include a general biocompatibility, plasmonic properties, enhanced surface reactivity, and ease of functionalization [4].…”

Section: Introductionmentioning

confidence: 99%

Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics

Comfort¹,

Speltz²,

Stacy³

et al. 2013

ANP

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Investigations into the use of gold nanorods (Au-NRs) for biological applications are growing exponentially due to their distinctive physicochemical properties, which make them advantageous over other nanomaterials. Au-NRs are particularly renowned for their plasmonic characteristics, which generate a robust photothermal response when stimulated with light at a wavelength matching their surface plasmon resonance. Numerous reports have explored this nanophotonic phenomenon for temperature driven therapies; however, to date there is a significant knowledge gap pertaining to the kinetic heating profile of Au-NRs within a controlled physiological setting. In the present study, the impact of environmental composition on Au-NR behavior and degree of laser actuated thermal production was assessed. Through acellular evaluation, we identified a loss of photothermal efficiency in biologically relevant fluids and linked this response to excessive particle aggregation and an altered Au-NR spectral profile. Furthermore, to evaluate the potential impact of solution composition on the efficacy of nano-based biological applications, the degree of targeted cellular destruction was ascertained in vitro and was found to be susceptible to fluid-dependent modifications. In summary, this study identified a diminution of Au-NR nanophotonic response in artificial physiological fluids that translated to a loss of application efficiency, pinpointing a critical concern that must be considered to advance in vivo, nano-based bio-applications.

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“…Some of those commonly used for PAT include spherical gold NPs [304, 314 -320] , nanorods [321 -327] , nanostars [328] , nanocages [305, 329 -334] , hollow nanoshells [335] , and composite materials with gold nanoshells: SiO 2 @Au, [306,336,337] Fe 3 O 4 @Au, [314] cobalt@gold NPs, [110] gold-speckled silica [316,320] , and gold nanobeacons [338,339] . The reasons for such an attention to gold nanosystems are many fold: they have tunable size-and shape-dependent plasmonic properties [340,341] , which allow them to absorb and scatter light from the visible to NIR region and make them suitable for image-guided therapy [325, 342 -344] and PTA of tumors [345 -347] .…”

Section: Gold-based Nanomaterialsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain

Cited by 439 publications

References 16 publications

Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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