Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

Ferrauto, Giuseppe; Carniato, Fabio; Gregorio, Enza Di; Botta, Maurizio

doi:10.1039/c9nr06524e

Cited by 12 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ferrauto et al [144] prepared a MSN-based theranostic nanosystem, in which the anticancer drug mitoxantrone was loaded into MSNs pores, while ICG attaching to the surface of the amino functionalized MSNs. This innovative theranostic nanosystem showed 1.75 times enhanced photoacoustic efficiency with respect to free ICG.…”

Section: Diagnostic and Theranosticmentioning

confidence: 99%

Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology

et al. 2020

View full text Add to dashboard Cite

Mesoporous silica nanoparticles (MSNs) have received increasing interest due to their tunable particle size, large surface area, stable framework, and easy surface modification. They are increasingly being used in varying applications as delivery vehicles including bio-imaging, drug delivery, biosensors and tissue engineering etc.Precise structure control and the ability to modify surface properties of MSNs are important for their applications. This review summarises the different synthetic methods for the preparation of well-ordered MSNs with tunable pore volume as well as the approaches of drugs loading, especially highlighting the facile surface 2 functionalization for various purposes and versatile biomedical applications in oncology. Finally, the challenges of clinical transformation of MSNs-based nanomedicines are further discussed.

show abstract

Section: Diagnostic and Theranosticmentioning

confidence: 99%

Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology

et al. 2020

View full text Add to dashboard Cite

show abstract

“…One widely photoacoustic contrast agent is ICG. This dye has been covalently grafted on MSN which contain on the surface a chemotherapeutic drug, mitoxantrone (MTX), which also exhibits NIR adsorption properties [ 47 ]. The conjugation of ICG on MSN increases the photoluminescence efficiency as well as its chemical stability.…”

Section: Photoacustic Theranosticsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines

Baeza

Vallet‐Regí

2020

Pharmaceutics

View full text Add to dashboard Cite

Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. The enhanced permeation and retention effect for loaded nanocarriers in tumors allow substantial improvement of selectivity and safety of anticancer nanomedicines. Additionally, the possibility to design stimuli-responsive nanocarriers able to release their payload in response to specific stimuli provide an excellent control on the administered dosage. The aim of this review is not to present a comprehensive revision of the different theranostic mesoporous silica nanoparticles (MSN) which have been published in the recent years but just to describe a few selected examples to offer a panoramic view to the reader about the suitability and effectiveness of these nanocarriers in the oncology field.

show abstract

“…Therefore, in turn, these phosphors could be potentially applied in horticulture research experiments. Biological tissue transmits radiation in the range from 650 to 1300 nm (the first biological window), which allows deeper penetration, so such compounds could also be promising candidates in the field of theranostics [37,38].…”

Section: Introductionmentioning

confidence: 99%

Characterization of GAGG Doped with Extremely Low Levels of Chromium and Exhibiting Exceptional Intensity of Emission in NIR Region

et al. 2021

View full text Add to dashboard Cite

Cerium and chromium co-doped gadolinium aluminum gallium garnets were prepared using sol-gel technique. These compounds potentially can be applied for NIR-LED construction, horticulture and theranostics. Additionally, magnesium and calcium ions were also incorporated into the structure. X-ray diffraction data analysis confirmed the all-cubic symmetry with an Ia-3d space group, which is appropriate for garnet-type materials. From the characterization of the luminescence properties, it was confirmed that both chromium and cerium emissions could be incorporated. Cerium luminescence was detected under 450 nm excitation, while for chromium emission, 270 nm excitation was used. The emission of chromium ions was exceptionally intense, although it was determined that these compounds are doped only by parts per million of Cr3+ ions. Typically, the emission maxima of chromium ions are located around 650–750 nm in garnet systems. However, in this case, the emission maximum for chromium is measured to be around 790 nm, caused by re-absorption of Cr3+ ions. The main observation of this study is that the switchable emission wavelength in a compound of single phase was obtained, despite the fact that doping with Cr ions was performed in ppm level, causing an intense emission in NIR region.

show abstract

Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

Abstract: A nanosystem based on mesoporous silica functionalized with ICG and the chemotherapeutic drug mitoxantrone has been exploited to introduce an innovative photoacoustic ratiometric approach for the assessment of drug release both in vitro and in vivo.

Cited by 12 publications

References 36 publications

Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology

Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology

Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines

Characterization of GAGG Doped with Extremely Low Levels of Chromium and Exhibiting Exceptional Intensity of Emission in NIR Region

Contact Info

Product

Resources

About