Photoacoustic radio-frequency spectroscopy (PA-RFS): A technique for monitoring absorber size and concentration

Hysi, Eno; Dopsa, Dustin; Kolios, Michael C.

doi:10.1117/12.2004991

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…As different plaques show varying absorption coefficient for the same incident laser [ 7 ], they generate photoacoustic signals with varying pressures, so their composition can be characterized in photoacoustic images. In addition to the improvement of tissue identification, photoacoustic imaging at multiple wavelengths resolves the concentrations of specific absorbers [ 8 ]. Recently, the advancement in IVPA imaging speed paved the way for its clinical translation [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Optical Ultrasound Generation and Detection for Intravascular Imaging: A Review

Zhao

Xia

2018

Journal of Healthcare Engineering

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Combined ultrasound and photoacoustic imaging has attracted significant interests for intravascular imaging such as atheromatous plaque detection, with ultrasound imaging providing spatial location and morphology and photoacoustic imaging highlighting molecular composition of the plaque. Conventional ultrasound imaging systems utilize piezoelectric ultrasound transducers, which suffer from limited frequency bandwidths and reduced sensitivity with miniature transducer elements. Recent advances on optical methods for both ultrasound generation and detection have shown great promise, as they provide efficient and ultrabroadband ultrasound generation and sensitive and ultrabroadband ultrasound detection. As such, all-optical ultrasound imaging has a great potential to become a next generation ultrasound imaging method. In this paper, we review recent developments on optical ultrasound transmitters, detectors, and all-optical ultrasound imaging systems, with a particular focus on fiber-based probes for intravascular imaging. We further discuss our thoughts on future directions on developing combined all-optical photoacoustic and ultrasound imaging systems for intravascular imaging.

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Section: Introductionmentioning

confidence: 99%

Optical Ultrasound Generation and Detection for Intravascular Imaging: A Review

Zhao

Xia

2018

Journal of Healthcare Engineering

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Probing Different Biological Length Scales Using Photoacoustics: From 1 To 1000 MHz

Hysi¹,

Strohm²,

Kolios³

2014

Handbook of Photonics for Biomedical Engineering

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Spectral Analysis of Ultrasonic and Photo Acoustic Signals Generated by a Prototypal Fiber Microprobe for Media Characterization

et al. 2020

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Combination of photoacoustics and ultrasound can provide complemental features and mutual benefits, useful for a complete tissue characterization and consequently for early diagnosis or therapy monitoring. Furthermore, minimally invasive techniques are required both to reach organs or tissue not accessible and to reduce patient discomfort and costs. This work has tested a prototypal microprobe for media characterization analysing their optical and mechanical features. Two different transmitters compose the miniaturized probe: one for large bandwidth ultrasonic signals generation and one for guiding the laser light into tissue to photogenerate ultrasound. The aim is to evaluate the possibility of employing in the future this new type of microprobe to characterize internal tissue, combining ultrasound and photoacoustic investigations. A calibrated commercial hydrophone has been used to detect generated signals, with the aim to provide repeatable and reliable results. Dedicated test objects have been realized by using solutions of corn starch flour and of Chinese ink with different and calibrated dilutions. The spectral algorithm HyperSPACE (Hyper SPectral Analysis for Characterization in Echography), applied on ultrasonic and photoacoustic signals has allowed differentiating scatterers’ concentration and distribution.

show abstract

Photoacoustic radio-frequency spectroscopy (PA-RFS): A technique for monitoring absorber size and concentration

Cited by 4 publications

References 14 publications

Optical Ultrasound Generation and Detection for Intravascular Imaging: A Review

Optical Ultrasound Generation and Detection for Intravascular Imaging: A Review

Probing Different Biological Length Scales Using Photoacoustics: From 1 To 1000 MHz

Spectral Analysis of Ultrasonic and Photo Acoustic Signals Generated by a Prototypal Fiber Microprobe for Media Characterization

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