Photoacoustic imaging of blood vessels in the chorioallantoic membrane of a chicken embryo

Kolkman, R.G.M.; Huisjes, Arjan; Siphanto, Ronald I.; Steenbergen, Wiendelt; Leeuwen, Ton G. van

doi:10.1117/12.528976

Cited by 1 publication

(2 citation statements)

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“…These time-trace waves disperse through the tissue and can be seized by the detector at the tissue surface. The dispersion time determines the photoacoustic position [ 173 ]. The strength and the profile of the captured signals carry the overall spatial information about the distribution of laser absorption in the tissue [ 174 ].…”

Section: Methods To Image and Evaluate The Changes In The Vasculatmentioning

confidence: 99%

“…A photoacoustic system was used to visualise single blood vessels in the CAM at ED 9, which revealed that the majority of vessels were sized from 200 to 500 µm in diameter, with other smaller vessels ranging from 125 to 200 µm. Meanwhile, through 3D rendering of the reconstructed dataset, the blood vessels’ structures of 3.5 mm depth became clearly visible [ 173 ]. In most cases, photoacoustic signals were acquired at flat and reflective surfaces.…”

Section: Methods To Image and Evaluate The Changes In The Vasculatmentioning

confidence: 99%

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Utilisation of Chick Embryo Chorioallantoic Membrane as a Model Platform for Imaging-Navigated Biomedical Research

Chen

Wang

Feng

et al. 2021

Cells

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The fertilised chick egg and particularly its chorioallantoic membrane (CAM) have drawn continuing interest in biomedicine and bioengineering fields, especially for research on vascular study, cancer, drug screening and development, cell factors, stem cells, etc. This literature review systemically introduces the CAM’s structural evolution, functions, vascular features and the circulation system, and cell regulatory factors. It also presents the major and updated applications of the CAM in assays for pharmacokinetics and biodistribution, drug efficacy and toxicology testing/screening in preclinical pharmacological research. The time course of CAM applications for different assays and their advantages and limitations are summarised. Among these applications, two aspects are emphasised: (1) potential utility of the CAM for preclinical studies on vascular-disrupting agents (VDAs), promising for anti-cancer vascular-targeted therapy, and (2) modern imaging technologies, including modalities and their applications for real-time visualisation, monitoring and evaluation of the changes in CAM vasculature as well as the interactions occurring after introducing the tested medical, pharmaceutical and biological agents into the system. The aim of this article is to help those working in the biomedical field to familiarise themselves with the chick embryo CAM as an alternative platform and to utilise it to design and optimise experimental settings for their specific research topics.

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Section: Methods To Image and Evaluate The Changes In The Vasculatmentioning

confidence: 99%

Section: Methods To Image and Evaluate The Changes In The Vasculatmentioning

confidence: 99%

Utilisation of Chick Embryo Chorioallantoic Membrane as a Model Platform for Imaging-Navigated Biomedical Research

Chen

Wang

Feng

et al. 2021

Cells

View full text Add to dashboard Cite

show abstract

Photoacoustic imaging of blood vessels in the chorioallantoic membrane of a chicken embryo

Abstract: Photoacoustic imaging is demonstrated in imaging blood vessels of a chicken embryo. Using a weighted sumand-delay beamforming algorithm we were able to reconstruct two-and three-dimensional images of these blood vessels.

Cited by 1 publication

References 12 publications

Utilisation of Chick Embryo Chorioallantoic Membrane as a Model Platform for Imaging-Navigated Biomedical Research

Utilisation of Chick Embryo Chorioallantoic Membrane as a Model Platform for Imaging-Navigated Biomedical Research

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