Photoacoustic-imaging-guided therapy of functionalized melanin nanoparticles: combination of photothermal ablation and gene therapy against laryngeal squamous cell carcinoma

Fan, Bo; Yang, Xi; Li, Xiaoyan; Lv, Shuxin; Zhang, Huanhu; Sun, Jinghua; Li, Liping; Wang, Lingjie; Qu, Botao; Peng, Xianjia; Zhang, Ruiping

doi:10.1039/c9nr01122f

Cited by 29 publications

(29 citation statements)

References 39 publications

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“…According to the authors, considered, the significant inhibition of tumor growth in vivo the proposed NP represent a valuable alternative for imaging guided GT-PTT. Another possibility in GT, which was adopted by Fan et al, is the use of small and endogenous non-coding RNA, known as microRNA (miRNA) [204]. The aforementioned miRNA In a similar way, Yang et al demonstrated the activity of a melanin-poly-l-lysine (M-PLL) polymer as a siRNA vehicle, able to the overcome the endosomal barrier and to deliver into the cytoplasm the functional genetic material [202].…”

Section: Ptt-gene Therapymentioning

confidence: 99%

“…According to the authors, considered, the significant inhibition of tumor growth in vivo the proposed NP represent a valuable alternative for imaging guided GT-PTT. Another possibility in GT, which was adopted by Fan et al, is the use of small and endogenous non-coding RNA, known as microRNA (miRNA) [204]. The aforementioned miRNA can control cancer-associated gene expression via the regulation of the level of messenger RNA or the suppression of the target mRNA translation.…”

Section: Ptt-gene Therapymentioning

confidence: 99%

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Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology.

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Section: Ptt-gene Therapymentioning

confidence: 99%

“…According to the authors, considered, the significant inhibition of tumor growth in vivo the proposed NP represent a valuable alternative for imaging guided GT-PTT. Another possibility in GT, which was adopted by Fan et al, is the use of small and endogenous non-coding RNA, known as microRNA (miRNA) [204]. The aforementioned miRNA can control cancer-associated gene expression via the regulation of the level of messenger RNA or the suppression of the target mRNA translation.…”

Section: Ptt-gene Therapymentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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“…S20-S22). PEGylated (poly(ethylene glycol) [PEG]) melanin nanoparticles were synthesized from commercial melanin granules according to a previously reported method (16)(17)(18). The theranostic probe 1 was prepared by functionalizing melanin dots with NIR-II molecular dye 3 to form 4 dots via the traditional coupling conditions and then loading Pt(II) metallacycle 2 via π-π binding to enable both imaging and therapy ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Nano-agent 1 tends to aggregate and form nanoparticles that are larger than the free melanin dots. This is due to the conjugation with the hydrophobic NIR-II dye 3 and binding with hydrophobic drugs that both decreased the hydrophilicity of the melanin dots and induced melanin dots' self-aggregation (16)(17)(18). Further experiments showed that the nano-agent 1 particle size was unchanged after incubation for 24 h in PBS containing 10% (vol/vol) FBS at 37°C.…”

Section: Resultsmentioning

confidence: 99%

“…Inspired by the intrinsic multifunctionality of melanin biopolymers in nature, highly biocompatible and water-soluble melanin dots have been used as active nanoplatforms for aromatic structures for drug delivery (15)(16)(17)(18). Compared with inorganic platforms, melanin exists in nature as an endogenous substance and has a better biocompatibility and clearance, which leads to reduced immunogenicity.…”

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confidence: 99%

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Melanin-dot–mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy

Sun

Ding

Chen

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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149

104

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Discrete Pt(II) metallacycles have potential applications in biomedicine. Herein, we engineered a dual-modal imaging and chemo-photothermal therapeutic nano-agent 1 that incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-infrared channel [NIR-II]) into multifunctional melanin dots with photoacoustic signal and photothermal features. Nano-agent 1 has a good solubility, biocompatibility, and stability in vivo. Both photoacoustic imaging and NIR-II imaging in vivo confirmed that 1 can effectively accumulate at tumor sites with good signal-to-background ratio and favorable distribution. Guided by precise dual-modal imaging, nano-agent 1 exhibits a superior antitumor performance and less severe side effects compared with a single treatment because of the high efficiency of the chemo-photothermal synergistic therapy. This study shows that nano-agent 1 provides a promising multifunctional theranostic platform for potential applications in biomedicine.

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Biogenic Imaging Contrast Agents

et al. 2023

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Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs.

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Photoacoustic-imaging-guided therapy of functionalized melanin nanoparticles: combination of photothermal ablation and gene therapy against laryngeal squamous cell carcinoma

Abstract: A photoacoustic imaging-guided anticancer strategy was developed based on poly-l-lysine functionalized melanin nanoparticles by integrating thermo-gene therapies.

Cited by 29 publications

References 39 publications

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Melanin-dot–mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy

Biogenic Imaging Contrast Agents

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