Photoacoustic Imaging for Noninvasive Periodontal Probing Depth Measurements

Lin, Ching-Yu; Chen, F.; Hariri, Ali; Chen, C.J.; Wilder‐Smith, Petra; Takesh, Thair; Jokerst, Jesse V.

doi:10.1177/0022034517729820

Cited by 41 publications

(60 citation statements)

References 36 publications

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“…Beside assessing the alveolar bone level, the use of ultrasound in diagnosing periapical inflammatory lesions of the jaw and periodontal bony defect has also been demonstrated [ 63 , 64 ]. High frequency ultrasound imaging (40 MHz) can also help accurately measure the gingival thickness and probing depth [ 65 ]. Especially in radiolucent areas where the cortices are thinned or absent, ultrasound imaging is highly possible for the reasons described previously.…”

Section: Discussionmentioning

confidence: 99%

Comparison of ultrasound imaging and cone-beam computed tomography for examination of the alveolar bone level: A systematic review

et al. 2018

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Background and objectiveThe current methods to image alveolar bone in humans include intraoral 2D radiography and cone-beam computed tomography (CBCT). However, these methods expose the subject to ionizing radiation. Therefore, ultrasound imaging has been investigated as an alternative technique, as it is both non-invasive and free from ionizing radiation. In order to assess the validity and reliability of ultrasonography in visualizing alveolar bone, a systematic review was conducted comparing ultrasound imaging to CBCT for examination of the alveolar bone level.Study designSeven databases were searched. Studies addressing examination of alveolar bone level via CBCT and ultrasound were selected. Risk of bias under Cochrane guidelines was used as a methodological quality assessment tool.ResultsAll the four included studies were ex vivo studies that used porcine or human cadaver samples. The alveolar bone level was measured by the distance from the alveolar bone crest to certain landmarks such as cemento-enamel junction or gingival margin. The risk of bias was found as low. The mean difference between ultrasound and CBCT measurements ranged from 0.07 mm to 0.68 mm, equivalent to 1.6% - 8.8%.ConclusionsThere is currently preliminary evidence to support the use of ultrasonography as compared to CBCT for the examination of alveolar bone level. Further studies comparing ultrasound to gold standard methods would be necessary to help validate the accuracy of ultrasonography as a diagnostic technique in periodontal imaging.

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Section: Discussionmentioning

confidence: 99%

Comparison of ultrasound imaging and cone-beam computed tomography for examination of the alveolar bone level: A systematic review

et al. 2018

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“…[ 3,5 ] In addition, PA imaging has been evaluated for the characterization of inflammatory bowel disease, [ 6 ] metabolism of brown fat, [ 7 ] Duchenne muscular dystrophy disease, [ 8 ] and the depth analysis of periodontal pockets. [ 9 ] Further applications in diagnostic investigation are ongoing. [ 10 ]…”

Section: Figurementioning

confidence: 99%

Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging

Merkes

Lammers

Kancherla

et al. 2020

Advanced Optical Materials

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Photoacoustic imaging (PAI) is increasingly employed in (pre‐) clinical research, thus, development of suitable contrast agents, in particular fluorescence‐quenched chromophores, for PAI is of high importance. Small molecule dyes are appropriate due to favorable circulation, excretion properties, and ease of conjugation to targeting moieties. The BODIPY chromophores have been widely used in bioimaging, yet they are not ideal for PAI due to high fluorescence. Hence, here nonfluorescent BODIPY are designed by 1H‐pyrrole conjugation (PyBODIPY) to apply as probes for PAI. The PyBODIPYs exhibit absorption maxima up to 800 nm, and PA signal could be detected in concentrations of 1 nmol mL−1 and 35 pmol mm−3, by tube and tissue phantom, respectively. In addition to nonfluorescent, PyBODIPYs are non‐phototoxic, photostable, and show high molar extinction coefficients, as well as inertness toward nucleophilic addition. PyBODIPYs are modified with PEG‐400, to improve aqueous solubility and to enable in vivo imaging. Thus, PyBODIPY is an attractive small molecule to use as PA contrast agent, which could be coupled to targeting ligands for in vivo use. In addition, 1H‐pyrrole conjugation might be applied to the design of novel near‐infrared ranged quenchers suitable for PAI, and promote the development of probes for clinical translation.

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“…Using photoacoustic ultrasound Lin et al performed high-spatial resolution imaging of probing depths on an experimental model using pig mandibles. Specific contrast from dental pockets was achieved with food-grade cuttlefish ink as a contrast medium [38].…”

Section: S30mentioning

confidence: 99%

Periodontal evaluation using a non-invasive imaging method (ultrasonography)

Chifor

Badea

Chifor

et al. 2019

Medicine and Pharmacy Reports

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The periodontal disease and gingival bleeding are highly prevalent in the adult population worldwide. The World Health Organization (WHO) data shows that 90–100% of the 34-year-old adults present gingival inflammation. Therefore, an investigation method is required to allow the assessment of the periodontal disease as well as the monitoring of the evolution of the gingival inflammation after periodontal treatments. Non-invasive and operator-independent methods for periodontal examination are necessary for diagnosing and monitoring the periodontal disease. The periodontal ultrasonography is a reliable technique for visualizing the anatomical elements which are necessary to diagnose the periodontal status. Using this imaging technique the dentino-enamel junction, the cortical bone, the radicular surface from the crown to the alveolar bone, the gingival tissue can be seen without interfering with those elements during the examination. Also, calculus visualization is possible before and after scaling in order to evaluate the quality of the treatment. Using 2D ultrasonography is not feasible in dental practice as it requires extensive experience and is also time consuming. The reproducibility of the 2D slices is very difficult in order to have the possibility to compare different investigations efficiently. 3D reconstructions of the periodontal tissue can be a very good alternative to eliminate the operator dependence. Ultrasonography allows the practitioner to visualize the anatomic elements involved in making a periodontal diagnosis. It also allows tracking of subsequent changes. This method is not commonly used for periodontal examination and further studies are required. Previous studies show that ultrasonography can be a reliable non-invasive method to diagnose and monitor the periodontal disease.

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Photoacoustic Imaging for Noninvasive Periodontal Probing Depth Measurements

Cited by 41 publications

References 36 publications

Comparison of ultrasound imaging and cone-beam computed tomography for examination of the alveolar bone level: A systematic review

Comparison of ultrasound imaging and cone-beam computed tomography for examination of the alveolar bone level: A systematic review

Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging

Periodontal evaluation using a non-invasive imaging method (ultrasonography)

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