Photoacoustic drug delivery: the effect of laser parameters on the spatial distribution of delivered drug

Shangguan, HanQun; Casperson, Lee W.; Shearin, Alan; Gregory, Kenton W.; Prahl, Scott A.

doi:10.1117/12.209907

Cited by 6 publications

(5 citation statements)

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“…73 PAI-guided interventions have been developed to use in cardiovascular system, 74,75 spinal system, 62 nerves, 65,76 tendons, 76 fetus, 77 lymph nodes, 14,78 and tumor occurring at different sites in the body. 66,67,78–82 It is extensively used for monitoring delivered drug, 83–87 and observing disease conditions, therapeutic outcomes, and subsequent tissue responses.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic image-guided interventions

Karthikesh

Yang

2019

Exp Biol Med (Maywood)

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Photoacoustic imaging has demonstrated its potential for diagnosis over the last few decades. In recent years, its unique imaging capabilities, such as detecting structural, functional and molecular information in deep regions with optical contrast and ultrasound resolution, have opened up many opportunities for photoacoustic imaging to be used during image-guided interventions. Numerous studies have investigated the capability of photoacoustic imaging to guide various interventions such as drug delivery, therapies, surgeries, and biopsies. These studies have demonstrated that photoacoustic imaging can guide these interventions effectively and non-invasively in real-time. In this minireview, we will elucidate the potential of photoacoustic imaging in guiding active and passive drug deliveries, photothermal therapy, and other surgeries and therapies using endogenous and exogenous contrast agents including organic, inorganic, and hybrid nanoparticles, as well as needle-based biopsy procedures. The advantages of photoacoustic imaging in guided interventions will be discussed. It will, therefore, show that photoacoustic imaging has great potential in real-time interventions due to its advantages over current imaging modalities like computed tomography, magnetic resonance imaging, and ultrasound imaging. Impact statement Photoacoustic imaging is an emerging modality for use in image-guided interventional procedures. This imaging technology has a unique ability to offer real-time, non-invasive, cost-effective, and radiation-free guidance in a real-world operating environment. This is substantiated in this article which sums up the current state and underlines promising results of research using photoacoustic imaging in guiding drug delivery, therapy, surgery, and biopsy. Hence, this minireview facilitates future research and real-world application of photoacoustic image-guided interventions.

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Section: Introductionmentioning

confidence: 99%

Photoacoustic image-guided interventions

Karthikesh

Yang

2019

Exp Biol Med (Maywood)

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“…Additionally, CS enhances the drug transport across the cell membrane and has been extensively utilized in DDS and tissue engineering [10] [11]. The physical DDS are: 1) Electrical to drive molecules electrically through the skin (i.e., iontophoresis) or create pores within the membrane (i.e., electroporation) [12], 2) Ultrasound [13], Laser ultrasound [14], Extra corporeal shock waves [15], Laser-induced shock waves [16] and Laser-induced cavitation [17] [18] [19]. Recently, it was also shown that the mechanisms for the enhanced mobility and laser transport of NPs are thought to be due to electromagnetic wave induced force (i.e.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, Visualization and Analysis of Fluorescein Sodium Encapsulated PLGA@CS Nanoparticles as Model for Photothermomechanical Drug Delivery Using Pulsed 532 nm Laser

Khosroshahi¹,

Mahmoodi²

2018

ANP

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PLGA/CS nanoparticles containing fluorescein sodium as drug model were synthesized and characterized to investigate the feasibility of laser-induced drug delivery using pulse 532 nm. The main objective was to investigate the photothermally-induced mechanical force for transporting the nanoparticles. An argon laser was used to excite the fluorescence of the samples after irradiation. The preliminary results indicated that the drug nanoparticles encapsulated trapped by the cavitation bubbles can be transported by photothermomechanical effect. Different regions of interactions are defined and while in our case, the thermoelastic does not apply due to higher fluences, vaporization and laser-induced thermal breakdown (LITB) including the plasma formation and shock waves played an important and major role. Threshold fluences of 2.8, 18 and 102 Jcm −2 corresponding to 0.28, 1.8 and 10 GWcm −2 and 3.8, 30, and 171 MPa are determined for ablation, vaporization and LITB mechanisms respectively. The secondary microbubbles due to explosion of the primary transient cavitation bubbles played a key role in delivery process. Despite the dominant argon laser brightness, the laser-induced fluorescence spectroscopy (LIFS) demonstrated the fluorescence emission of the cavitation bubbles carrying due to the drug nanoparticles entrapped within the biogelatin after exposure to laser radiation, the irradiation, which confirms the possibility of transport of drug nanoparticles by laser cavitation. Finally, it is How to cite this paper: Khosroshahi, M.E. and Mahmoodi, M.

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“…The generated local hyperthermia can further promote encapsulated therapeutics diffusion from the agents, as well as facilitate cellular uptake as a result of increased membrane permeability for enhanced chemotherapy [ 32 , 33 ]. It was reported that the ultrasonic pressure produced by PA effect could be used to promote transdermal drug delivery, as well as localized drug release in vessels [ 34 , 35 , 36 ]. Researchers have also explored PAI agents as drug carriers, where the heat generated by the agent upon laser irradiation can control the drug release in an on-demand manner.…”

Section: Introductionmentioning

confidence: 99%