Photoacoustic assessment of hemodynamic changes in foot vessels

Yang, Jinge; Zhang, Guang; Wu, Man; Shang, Qiquan; Huang, Lin; Jiang, Huabei

doi:10.1002/jbio.201900004

Cited by 26 publications

(22 citation statements)

References 53 publications

(78 reference statements)

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“…This type of study is feasible in humans. 22,28,29 A potential limitation of PAI is the depth penetration. Although imaging depth depends on optical and acoustic values of the tissue and can vary greatly, 22 depth penetration of 5 to 7 cm can be achieved and should be adequate for imaging calf muscles in humans.…”

Section: Discussionmentioning

confidence: 99%

“…21,22 The PAI technique has widely been used over the past decade for noninvasive cancer detection, diagnosis, and staging, [23][24][25] but its ability to monitor limb oxygenation and vascular dysfunction by peripheral arteries is in its infancy. [26][27][28][29] The goal of this study is to investigate the potential of PAI for evaluating oxygenation changes associated with PAD. As age is an independent unmodifiable risk factor, the study is performed in mice from different age cohorts to determine the differences in limb oxygenation with age.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Age-related Oxygenation Changes in Calf Skeletal Muscle by Photoacoustic Imaging: A Potential Tool for Peripheral Arterial Disease

et al. 2019

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Peripheral artery disease is often asymptomatic, and various imaging and nonimaging techniques have been used for assessment and monitoring treatments. This study is designed to demonstrate the ability of photoacoustic imaging to noninvasively determine changes in tissue oxygenation that occur in mice’s hind limb skeletal muscle as they age. Mice from two age cohorts were scanned bilaterally with a pulsed laser. The photoacoustic signal was unmixed to generate a parametric map of estimated oxygen saturation and then overlaid on grayscale ultrasound images. Tissue oxygenation measured in young and old mice was compared. Photoacoustic imaging visually and quantitatively showed the decrease in skeletal muscle oxygenation that occurs with age. Percent tissue oxygenation decreased from 30.2% to 3.5% ( p < 0.05). This reduction corresponded to reduced fractional area of oxygenation, which decreased from 60.6% to 6.0% ( p < 0.05). The change in oxygenation capacity of the still active vascular regions was insignificant ( p > 0.05). Intrasubject, intra-, and interobserver comparisons showed low variability in measurements, exhibited by high regression and intraclass correlations exceeding 0.81 for all ages. The decrease in oxygenation detected by photoacoustic imaging paralleled the known oxygenation decrease observed in aging tissues, demonstrating that photoacoustic imaging can assess age-related changes in a mouse calf muscle. These intramuscular changes could potentially act as a strong diagnostic marker for peripheral artery disease. This study thus opens the doors for a novel, affordable, noninvasive method of evaluation free of radiation or exogenous material.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of Age-related Oxygenation Changes in Calf Skeletal Muscle by Photoacoustic Imaging: A Potential Tool for Peripheral Arterial Disease

et al. 2019

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“…At the moment, only a few examples of in vivo studies are conducted in the field of diabetes using PAT. In the work of Yang et al [201] it was shown that PAT has a potential in the diagnosis of vascular function (on the example of changes arising from arterial and venous occlusion).…”

Section: Optical Approaches In Diagnosticsmentioning

confidence: 99%

Biophotonics methods for functional monitoring of complications of diabetes mellitus

Zharkikh

Dremin

Zherebtsov

et al. 2020

Journal of Biophotonics

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The prevalence of diabetes complications is a significant public health problem with a considerable economic cost. Thus, the timely diagnosis of complications and prevention of their development will contribute to increasing the length and quality of patient life, and reducing the economic costs of their treatment. This article aims to review the current state-of-the-art biophotonics technologies used to identify the complications of diabetes mellitus and assess the quality of their treatment. Additionally, these technologies assess the structural and functional properties of biological tissues, and they include capillaroscopy, laser Doppler flowmetry and hyperspectral imaging, laser speckle contrast imaging, diffuse reflectance spectroscopy and imaging, fluorescence spectroscopy and imaging, optical coherence tomography, optoacoustic imaging and confocal microscopy. Recent advances in the field of optical noninvasive diagnosis suggest a wider introduction of biophotonics technologies into clinical practice and, in particular, in diabetes care units.

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“…PAI can be employed potentially to identify early stage pressure or diabetic ulcers and track their treatment progress. Yang et al demonstrated the capabilities of PAI to image hemodynamic changes in the foot on two groups of volunteers with different age groups [49]. PAI indicated a weaker vascular function in the older group, demonstrating PAI's value in early detection of diabetic foot ulcers.…”

Section: Wound Imagingmentioning

confidence: 99%

Clinical noninvasive imaging and spectroscopic tools for dermatological applications: Review of recent progress

Attia

Dev

et al. 2020

Transl Biophotonics

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Dermatologists mainly entrust visual clinical examinations in conjunction with histopathology for an informed skin condition diagnosis, which is invasive and not adequate to assess skin conditions still present in subcutaneous skin layers. With emerging complementary imaging and spectroscopic technologies currently available, the assessment of skin conditions is more accessible than before. This review article will cover these technologies including: photoacoustic imaging, reflectance confocal microscopy, multiphoton microscopy, optical coherence tomography and confocal Raman spectroscopy. The basic concepts of these technologies and their configurations will be touched on, together with their limitations and future directions. The review article will discuss how these technologies are utilized for cutaneous applications, examining studies accomplished either in vivo on humans or on ex vivo human specimens.

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Photoacoustic assessment of hemodynamic changes in foot vessels

Cited by 26 publications

References 53 publications

Assessment of Age-related Oxygenation Changes in Calf Skeletal Muscle by Photoacoustic Imaging: A Potential Tool for Peripheral Arterial Disease

Assessment of Age-related Oxygenation Changes in Calf Skeletal Muscle by Photoacoustic Imaging: A Potential Tool for Peripheral Arterial Disease

Biophotonics methods for functional monitoring of complications of diabetes mellitus

Clinical noninvasive imaging and spectroscopic tools for dermatological applications: Review of recent progress

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