Photoacoustic and Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated Ultra-Small NaGdF4 Nanoparticles for Spatiotemporal Modulation of Hypoxia in Head and Neck Cancer

Rich, Laurie J.; Damasco, Jossana A.; Bulmahn, Julia C.; Kutscher, Hilliard L.; Prasad, Paras N.; Seshadri, Mukund

doi:10.3390/cancers12113294

Cited by 22 publications

(21 citation statements)

References 25 publications

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“…Among the metal-based materials for generating oxygen through H 2 O 2 decomposition, MnO 2 is a widely studied material [ 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 ]. MnO 2 could produce oxygen and Mn 2+ at acidic pH, particularly in the presence of H 2 O 2 .…”

Section: Strategies For Modulating Tumor Hypoxia In Pdtmentioning

confidence: 99%

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Liang

Luo

et al. 2022

Biomolecules

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Photodynamic therapy (PDT) is a treatment modality that uses light to target tumors and minimize damage to normal tissues. It offers advantages including high spatiotemporal selectivity, low side effects, and maximal preservation of tissue functions. However, the PDT efficiency is severely impeded by the hypoxic feature of tumors. Moreover, hypoxia may promote tumor metastasis and tumor resistance to multiple therapies. Therefore, addressing tumor hypoxia to improve PDT efficacy has been the focus of antitumor treatment, and research on this theme is continuously emerging. In this review, we summarize state-of-the-art advances in strategies for overcoming hypoxia in tumor PDTs, categorizing them into oxygen-independent phototherapy, oxygen-economizing PDT, and oxygen-supplementing PDT. Moreover, we highlight strategies possessing intriguing advantages such as exceedingly high PDT efficiency and high novelty, analyze the strengths and shortcomings of different methods, and envision the opportunities and challenges for future research.

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Section: Strategies For Modulating Tumor Hypoxia In Pdtmentioning

confidence: 99%

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Liang

Luo

et al. 2022

Biomolecules

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Section: Photoacoustic Imaging and Mrimentioning

confidence: 99%

“…MnO 2 is oxidized to Mn II in acidic environments by hydrogen peroxide to produce O 2 and H 2 O. Degradation of MnO 2 not only releases paramagnetic Mn II but also exposes Gd III incorporated in the ultrasmall nanoparticles that enhance contrast in T 1 -weighted MRI. Because dissociation of MnO 2 produces O 2 , photoacoustic imaging was used to differentiate the optical absorption properties between oxygenated hemoglobin and deoxygenated hemoglobin to estimate oxygen saturation in tumor hypoxic environments [373]. Lu, Fan, and co-workers examined polymer-MnO 2 nanoparticles for dual-activatable photoacoustic and magnetic resonance bimodal imaging in tumor-bearing mice [369].…”

Section: Photoacoustic Imaging and Mrimentioning

confidence: 99%

“…Prasad and co-workers reported ultra-small NaYF 4 :Nd III /NaGdF 4 nanocrystals coated with manganese dioxide (MnO 2 ) for modulation and imaging of hypoxia in head and neck squamous cell carcinomas ( Figure 57 ) [ 373 ]. MnO 2 is oxidized to Mn II in acidic environments by hydrogen peroxide to produce O 2 and H 2 O. Degradation of MnO 2 not only releases paramagnetic Mn II but also exposes Gd III incorporated in the ultrasmall nanoparticles that enhance contrast in T 1 -weighted MRI.…”

Section: Dual-mode Hypoxia-responsive Probesmentioning

confidence: 99%

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Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions

et al. 2022

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Hypoxia in solid tumors is associated with poor prognosis, increased aggressiveness, and strong resistance to therapeutics, making accurate monitoring of hypoxia important. Several imaging modalities have been used to study hypoxia, but each modality has inherent limitations. The use of a second modality can compensate for the limitations and validate the results of any single imaging modality. In this review, we describe dual-mode imaging systems for the detection of hypoxia that have been reported since the start of the 21st century. First, we provide a brief overview of the hallmarks of hypoxia used for imaging and the imaging modalities used to detect hypoxia, including optical imaging, ultrasound imaging, photoacoustic imaging, single-photon emission tomography, X-ray computed tomography, positron emission tomography, Cerenkov radiation energy transfer imaging, magnetic resonance imaging, electron paramagnetic resonance imaging, magnetic particle imaging, and surface-enhanced Raman spectroscopy, and mass spectrometric imaging. These overviews are followed by examples of hypoxia-relevant imaging using a mixture of probes for complementary single-mode imaging techniques. Then, we describe dual-mode molecular switches that are responsive in multiple imaging modalities to at least one hypoxia-induced pathological change. Finally, we offer future perspectives toward dual-mode imaging of hypoxia and hypoxia-induced pathophysiological changes in tumor microenvironments.

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“…Hypoxia is also known to negatively influence treatment response to chemotherapy [ 27 ] and immunotherapy [ 20 , 28 ], as well as contributing to tumor aggressiveness [ 29 , 30 , 31 , 32 , 33 ]. A recent Special Issue in Cancers contained several original reports and contemporary review papers on the subject of tumor hypoxia [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. In this review, we will consider how thermal dose affects tumor hypoxia and, in turn, whether changes in hypoxia in response to thermoradiotherapy can influence treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

Accurate Three-Dimensional Thermal Dosimetry and Assessment of Physiologic Response Are Essential for Optimizing Thermoradiotherapy

Dewhirst

Oleson

Kirkpatrick

et al. 2022

Cancers

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Numerous randomized trials have revealed that hyperthermia (HT) + radiotherapy or chemotherapy improves local tumor control, progression free and overall survival vs. radiotherapy or chemotherapy alone. Despite these successes, however, some individuals fail combination therapy; not every patient will obtain maximal benefit from HT. There are many potential reasons for failure. In this paper, we focus on how HT influences tumor hypoxia, since hypoxia negatively influences radiotherapy and chemotherapy response as well as immune surveillance. Pre-clinically, it is well established that reoxygenation of tumors in response to HT is related to the time and temperature of exposure. In most pre-clinical studies, reoxygenation occurs only during or shortly after a HT treatment. If this were the case clinically, then it would be challenging to take advantage of HT induced reoxygenation. An important question, therefore, is whether HT induced reoxygenation occurs in the clinic that is of radiobiological significance. In this review, we will discuss the influence of thermal history on reoxygenation in both human and canine cancers treated with thermoradiotherapy. Results of several clinical series show that reoxygenation is observed and persists for 24–48 h after HT. Further, reoxygenation is associated with treatment outcome in thermoradiotherapy trials as assessed by: (1) a doubling of pathologic complete response (pCR) in human soft tissue sarcomas, (2) a 14 mmHg increase in pO2 of locally advanced breast cancers achieving a clinical response vs. a 9 mmHg decrease in pO2 of locally advanced breast cancers that did not respond and (3) a significant correlation between extent of reoxygenation (as assessed by pO2 probes and hypoxia marker drug immunohistochemistry) and duration of local tumor control in canine soft tissue sarcomas. The persistence of reoxygenation out to 24–48 h post HT is distinctly different from most reported rodent studies. In these clinical series, comparison of thermal data with physiologic response shows that within the same tumor, temperatures at the higher end of the temperature distribution likely kill cells, resulting in reduced oxygen consumption rate, while lower temperatures in the same tumor improve perfusion. However, reoxygenation does not occur in all subjects, leading to significant uncertainty about the thermal–physiologic relationship. This uncertainty stems from limited knowledge about the spatiotemporal characteristics of temperature and physiologic response. We conclude with recommendations for future research with emphasis on retrieving co-registered thermal and physiologic data before and after HT in order to begin to unravel complex thermophysiologic interactions that appear to occur with thermoradiotherapy.

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Photoacoustic and Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated Ultra-Small NaGdF4 Nanoparticles for Spatiotemporal Modulation of Hypoxia in Head and Neck Cancer

Cited by 22 publications

References 25 publications

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions

Accurate Three-Dimensional Thermal Dosimetry and Assessment of Physiologic Response Are Essential for Optimizing Thermoradiotherapy

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