Photo-uncaging a Ru(ii) intercalator via photodecomposition of a bridged Mn(i) photoCORM

Abstract

A Ru(II) intercalating complex capped with a Mn(I) photoCORM allows for a new mode of DNA intercalator delivery. The steric bulk of the Mn(I) photoCORM inhibits intercalation in the dark,...

Photoinduced [2+2] and [4+4] Cycloaddition and Cycloreversion Reactions for the Development of Photocontrollable DNA Binders

“…[24] In particular, according to the general concept of photoinduced fragmentation reactions to release bioactive fragments [25] the DNAbinding properties of sterically demanding metal complexes can be changed by photoinduced exchange or displacement of the complex ligands. [26] Besides the control of DNA-binding modes, photoswitchable DNA-ligands were also employed to regulate the hybridization of oligonucleotides. [27] Furthermore, photoswitchable ligands were used to control the interconversion of various non-canonical DNA forms, including quadruplex DNA and the i-motif.…”

M-CPOnes: transition metal complexes with cyclopropenone-based ligands for light-triggered carbon monoxide release

“…14,15 For applications, the CORM should have good stability but triggerable and quantitative CO release as well as tunable photophysical properties and synthetic accessibility. 16 Photo-CORMs [17][18][19][20] take advantage of the spatial and temporal control of light to release carbon monoxide upon irradiation 16,21 and in some cases, the loss of carbon monoxide could be tracked by fluorescence. [22][23][24] While cyclopropenones 25,26 undergo efficient photolysis 27,28 upon irradiation with light resulting in carbon monoxide release and alkyne formation, they have been largely overlooked as CORMs.…”

“…Photo-CORMs 17–20 take advantage of the spatial and temporal control of light to release carbon monoxide upon irradiation 16,21 and in some cases, the loss of carbon monoxide could be tracked by fluorescence. 22–24 While cyclopropenones 25,26 undergo efficient photolysis 27,28 upon irradiation with light resulting in carbon monoxide release and alkyne formation, they have been largely overlooked as CORMs.…”