Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles

Sivakumar, P.; Lee, Minjong; Kim, Yoon-Seok; Shim, Min Suk

doi:10.1039/c8tb00948a

Cited by 138 publications

(64 citation statements)

References 119 publications

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“…Of course this review does not cover and exhaust the whole area of surface modification of bulk materials for antibacterial and antibiofilm use. Surfaces releasing quaternary ammonium salts, peptides,, antibiotics, materials coated with graphene, with Zinc oxide NP, and with superhydrophobic polymers, are some of the most frequently encountered examples in recent literature. However, in this wide context self‐assembled monolayers of AgNP prepared with the LbL technique are a subset with some unique advantages.…”

Section: Discussionmentioning

confidence: 99%

Self‐Assembled Monolayers of Silver Nanoparticles: From Intrinsic to Switchable Inorganic Antibacterial Surfaces

2018

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The layer‐by‐layer technique allows to graft molecular monolayers on bulk surfaces that, in turn, allow to graft monolayers of metal nanoparticles. This microreview focuses on the preparation of such materials featuring a monolayer of silver nanoparticles (AgNP) and their use as antimicrobial surfaces against both planktonic bacteria and biofilms. The role of Ag+ release and of direct cell/AgNP contact in the antibacterial action will be stressed as a function of the adhesive molecular layer, of the AgNP dimension and shape, of their surface density, and of the molecular overcoating. While these surfaces display an intrinsic antibacterial action, a further evolution will also be reviewed, in which additional photothermal antibacterial action can be switched on demand, using near‐IR radiation and non‐spherical AgNP or a combination of AgNP with non‐spherical AuNP. The intrinsic and switchable photothermal action of these surfaces will be unraveled, and their synergistic effect stressed.

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Section: Discussionmentioning

confidence: 99%

Self‐Assembled Monolayers of Silver Nanoparticles: From Intrinsic to Switchable Inorganic Antibacterial Surfaces

2018

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“…From the above equilibrium, it is evident that the free nanoparticles are always available and remain in a dynamic equilibrium with the coated ones. These free NPs are responsible for interacting with the microbial cell wall through several reported mechanisms including ROS generation [48][49][50][51][52][53]. This further facilitates the interaction of the positively charged ZnO NP with the negatively charged molecules on the cell surface and providing channels for easy delivery of the antibiotic [54].…”

Section: Discussionmentioning

confidence: 99%

Preparation and Evaluation of the ZnO NP–Ampicillin/Sulbactam Nanoantibiotic: Optimization of Formulation Variables Using RSM Coupled GA Method and Antibacterial Activities

et al. 2019

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Nanoparticles (NPs) possessing antibacterial activity represent an effective way of overcoming bacterial resistance. In the present work, we report a novel formulation of a nanoantibiotic formed using Ampicillin/sulbactam (Ams) and a zinc oxide nanoparticle (ZnO NP). 'ZnO NP-Ams' nanoantibiotic formulation is optimized using response surface methodology coupled genetic algorithm approach. The optimized formulation of nanoantibiotic (ZnO NP: 49.9 µg/mL; Ams: 33.6 µg/mL; incubation time: 27 h) demonstrated 15% enhanced activity compared to the unoptimized formulation against K. pneumoniae. The reactive oxygen species (ROS) generation was directly proportional to the interaction time of nanoantibiotic and K. pneumoniae after the initial lag phase of 18 h as evident from 2s'-7'-Dichlorodihydrofluorescein diacetate assay. A low minimum inhibitory concentration (6.25 µg/mL) of nanoantibiotic formulation reveals that even a low concentration of nanoantibiotic can prove to be effective against K. pneumoniae. The importance of nanoantibiotic formulation is also evident by the fact that the 100 µg/mL of Ams and 25 µg of ZnO NP was required individually to inhibit the growth of K. pneumonia, whereas only 6.25 µg/mL of optimized nanoantibiotic formulation (ZnO NP and Ams in the ratio of 49.9: 33.6 in µg/mL and conjugation time of 27 h) was needed for the same.

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“…When irradiated by light (usually UV light), photoexcited metal oxides, such as ZnO and TiO 2 , can efficiently generate ROS by charge separation and creation of electron–hole pairs . As shown in Figure a, the surface of ZnO NPs facilitates electron (e − ) transfer from the valence band to the conduction band after light irradiation, leaving a hole (h + ); the electrons and holes react with adjacent O 2 and H 2 O, respectively, to generate O 2 − and •OH for antibacterial treatment . The hybridization of noble metals (especially Au and Ag) can improve the photo‐antibacterial properties of metal oxides by increasing their photoenergy conversion efficiency .…”

Section: Development Of Antibacterial Pssmentioning

confidence: 99%

Section: Development Of Antibacterial Pssmentioning

confidence: 99%

Rejuvenated Photodynamic Therapy for Bacterial Infections

Jia

Song

et al. 2019

Adv Healthcare Materials

295

208

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The emergence of multidrug resistant bacterial strains has hastened the exploration of advanced microbicides and antibacterial techniques. Photodynamic antibacterial therapy (PDAT), an old‐fashioned technique, has been rejuvenated to combat “superbugs” and biofilm‐associated infections owing to its excellent characteristics of noninvasiveness and broad antibacterial spectrum. More importantly, bacteria are less likely to produce drug resistance to PDAT because it does not require specific targeting interaction between photosensitizers (PSs) and bacteria. This review mainly focuses on recent developments and future prospects of PDAT. The mechanisms of PDAT against bacteria and biofilms are briefly introduced. In addition to classical macrocyclic PSs, several innovative PSs, including non‐self‐quenching PSs, conjugated polymer–based PSs, and nano‐PSs, are summarized in detail. Numerous multifunctional PDAT systems such as in situ light‐activated PDAT, stimuli‐responsive PDAT, oxygen self‐enriching enhanced PDAT, and PDAT‐based multimodal therapy are highlighted to overcome the inherent defects of PDAT in vivo (e.g., limited penetration depth of light and hypoxic environment of infectious sites).

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Photo-triggered antibacterial and anticancer activities of zinc oxide nanoparticles

Cited by 138 publications

References 119 publications

Self‐Assembled Monolayers of Silver Nanoparticles: From Intrinsic to Switchable Inorganic Antibacterial Surfaces

Self‐Assembled Monolayers of Silver Nanoparticles: From Intrinsic to Switchable Inorganic Antibacterial Surfaces

Preparation and Evaluation of the ZnO NP–Ampicillin/Sulbactam Nanoantibiotic: Optimization of Formulation Variables Using RSM Coupled GA Method and Antibacterial Activities

Rejuvenated Photodynamic Therapy for Bacterial Infections

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