Photo-switchable supramolecular comb-like polymer brush based on host–guest recognition for use as antimicrobial smart surface

Zheng, Si Yu; Ni, Yifeng; Zhou, Jiahui; Gu, Yucong; Wang, Yiting; Yuan, Jingfeng; Wang, Xiaoyu; Zhang, Dong; Liu, Shanqiu; Yang, Jintao

doi:10.1039/d2tb00206j

Cited by 9 publications

(8 citation statements)

References 51 publications

(58 reference statements)

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“…Green-labeled cells represent viable cells, while red-labeled cells indicate dead cells. The detail of the experiment was prepared with a similar method in the literature [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Azobenzene Based Photo-Responsive Hydrogel: Synthesis, Self-Assembly, and Antimicrobial Activity

Yang

Jin

Huang

et al. 2022

Gels

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A new azobenzene-based symmetric amphiphile was synthesized and characterized using 1H NMR spectroscopy. Its self-assembly behavior as well as photo-responsive behavior in its solution and gel states were investigated. Such a compound can self-assemble into fiber mesophases in water solvent. After irradiation of the gels with UV light, the trans isomer of the compound rapidly photoisomerized to the cis isomer, which resulted in a rapid destruction of the gel. High temperature also caused a rapid drop in viscosity. To verify the antimicrobial activity of the hydrogel, live and death assays of human fibroblasts L929 properties were used for in vitro cell viability studies. The compound was converted to the terminal tertiary amine in a quaternary ammonium salt molecule by using hydrochloric acid. This azobenzene quaternary ammonium salt has a relatively better antimicrobial effect biocidal activity that was demonstrated when challenged against Escherichia coli on in vitro conditions.

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“…Green-labeled cells represent viable cells, while red-labeled cells indicate dead cells. The detail of the experiment was prepared with a similar method in the literature [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Azobenzene Based Photo-Responsive Hydrogel: Synthesis, Self-Assembly, and Antimicrobial Activity

Yang

Jin

Huang

et al. 2022

Gels

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“…This was mainly because opposing charges of zwitterionic moieties in hydrogel can induce a high hydration layer and thus build a high hydration barrier. [34] Not only that, CMCS also provided an amphoteric environment in hydrogel owing to the carboxyl and amino groups, [44,45] which ultimately eliminated most nonspecific signals acting on ADSCs.…”

Section: Stemness Maintenancementioning

confidence: 99%

“…Zwitterionic hydrogels have excellent biocompatibility and ultralow protein adsorption, which showed potential applications for use as bio-electrodes, renewable biomedical interfaces and tissue engineering. [32][33][34] Their superhydrophilic and antiprotein nonspecific adhesion properties are beneficial to prevent wound infection and resist the foreign-body reaction for a long time in vivo. [35,36] For instance, Jiang et al reported that the poly(carboxybetaine) zwitterionic hydrogel can significantly alleviate immune activation in vivo.…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic Polysaccharide‐Based Hydrogel Dressing as a Stem Cell Carrier to Accelerate Burn Wound Healing

Sun

Yue

et al. 2022

Adv Healthcare Materials

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Stem cell therapy integrated with hydrogels has shown promising potential in wound healing. However, the existing hydrogels usually cannot reach the desired therapeutic efficacy for burn wounds due to the inadaptability to wound shape and weak anti-infection ability. Moreover, it is difficult to improve the environment for the survival and function of stem cells under complicated wound microenvironments. In this study, an injectable and self-healing hydrogel (DSC), comprising sulfobetaine-derived dextran and carboxymethyl chitosan, is fabricated through a Schiff-base reaction. Meanwhile, the DSC hydrogel shows high nonfouling properties, including resistance to bacteria and nonspecific proteins; moreover, the prepared hydrogel can provide a biomimetic microenvironment for cell proliferation whilst maintaining the stemness of adipose-derived stem cells (ADSCs) regardless of complex microenvironments. In burnt murine animal models, the ADSCs-laden hydrogel can significantly accelerate wound healing rate and scarless skin tissue regeneration through multiple pathways. Specifically, the ADSCs-laden DSC hydrogel can avoid immune system recognition and activation and thus reduce the inflammatory response. Moreover, the ADSCs-laden DSC hydrogel can promote collagen deposition, angiogenesis, and enhance macrophage M2 polarization in the wound area. In summary, sulfobetaine-derived polysaccharide hydrogel can serve as a versatile platform for stem cell delivery to promote burn wound healing.

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“…In a recent work of Zheng et al [ 100 ], azobenzene is used in an antibacterial and photo responsive polymeric material based on host-guest interactions. The material, obtained by surface modification, consists of an azo-functionalized antibacterial polymer, poly((2-(methacryloxy)ethyl)) trimethyl ammonium chloride (Azo-PMETAC), an antifouling polymer, and an azo-modified poly(sulfobetaine methacrylate) (Azo-PSBMA) ( Figure 34 a).…”

Section: Azo Compounds In Antimicrobial Peptides and Polymersmentioning

confidence: 99%

“… ( a ) chemical structures of components in photoswitchable supramolecular polymer brush; and ( b ) the process of antibacterial surfaces [ 100 ]. …”

Section: Figurementioning

confidence: 99%

Azobenzene as Antimicrobial Molecules

et al. 2022

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Azo molecules, characterized by the presence of a -N=N- double bond, are widely used in various fields due to their sensitivity to external stimuli, ch as light. The emergence of bacterial resistance has pushed research towards designing new antimicrobial molecules that are more efficient than those currently in use. Many authors have attempted to exploit the antimicrobial activity of azobenzene and to utilize their photoisomerization for selective control of the bioactivities of antimicrobial molecules, which is necessary for antibacterial therapy. This review will provide a systematic and consequential approach to coupling azobenzene moiety with active antimicrobial molecules and drugs, including small and large organic molecules, such as peptides. A selection of significant cutting-edge articles collected in recent years has been discussed, based on the structural pattern and antimicrobial performance, focusing especially on the photoactivity of azobenzene and the design of smart materials as the most targeted and desirable application.

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Photo-switchable supramolecular comb-like polymer brush based on host–guest recognition for use as antimicrobial smart surface

Abstract: Bacterial infections of biomedical devices have posed great threat to the health of human and placed a heavy burden on society. Therefore, developing efficient antibacterial surface has attracted high attentions;...

Cited by 9 publications

References 51 publications

Azobenzene Based Photo-Responsive Hydrogel: Synthesis, Self-Assembly, and Antimicrobial Activity

Azobenzene Based Photo-Responsive Hydrogel: Synthesis, Self-Assembly, and Antimicrobial Activity

Zwitterionic Polysaccharide‐Based Hydrogel Dressing as a Stem Cell Carrier to Accelerate Burn Wound Healing

Azobenzene as Antimicrobial Molecules

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