Photo-sonodynamic therapy mediated with OLI_NPs to induce HPV16E7-specific immune response and inhibit cervical cancer in a Tc-1-grafted murine model

Zhao, Guangzong; Chen, Shuning; Zheng, Jiao; Li, Chenyang; Zhong, Xiaowen; Cao, Ye‐Xuan; Zheng, Yue; Sun, Jiao; Zhu, Shirley; Chang, Shufang

doi:10.1016/j.jphotobiol.2022.112583

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…In the photochemical study, the obtained singlet oxygen quantum yields values (Table 1 )were 0.43 for Si1a , 0.94 for Q-Si1a , 0.58 for S-Si1a , and 0.49 for B-Si1a. Besides, the synergic effect of light irradiation all along with ultrasounds on the singlet oxygen formation increasing ability of a sensitizer has been reported in literature [ 33 – 36 ]. The obtained Φ Δ values in this study are 0.67 for Si1a , 1.06 for Q-Si1a , 0.65 for S-Si1a , and 0.67 for B-Si1a .…”

Section: Resultsmentioning

confidence: 99%

Monitoring of singlet oxygen generation of a novel Schiff-base substituted silicon phthalocyanines by sono-photochemical studies and in vitro activities on prostate cancer cell

Messaoudi,

Yaşa Atmaca,

Türkkol

et al. 2024

J Biol Inorg Chem

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This study demonstrates the potential of sono-photodynamic therapy as an effective approach for enhancing singlet oxygen generation using the synthesized Schiff-base diaxially substituted silicon phthalocyanines. In photochemical studies, the singlet oxygen quantum yields (Φ∆) were determined as 0.43 for Si1a, 0.94 for Q-Si1a, 0.58 for S-Si1a, and 0.49 for B-Sia1. In sono-photochemical studies, the Φ∆ values were reached to 0.67 for Si1a, 1.06 for Q-Si1a, 0.65 for S-Si1a, and 0.67 for B-Sia1. In addition, this study demonstrates the therapeutic efficacy of phthalocyanines synthesized as sensitizers on the PC3 prostate cancer cell line through in vitro experiments. The application of these treatment modalities exhibited notable outcomes, leading to a substantial decrease in cell viability within the PC3 prostate cancer cell line. These findings highlight the potential of utilizing these synthesized phthalocyanines as promising therapeutic agents for prostate cancer treatment. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Monitoring of singlet oxygen generation of a novel Schiff-base substituted silicon phthalocyanines by sono-photochemical studies and in vitro activities on prostate cancer cell

Messaoudi,

Yaşa Atmaca,

Türkkol

et al. 2024

J Biol Inorg Chem

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“…In studies by Kenarkoohi et al [ 69 , 70 ], HSVtk-expressing mouse AT-MSC (AT-MSC HSVtk ) was constructed by transduction with the lentiviral vector carrying HSVtk gene. It is noted that TC-1 cell lines, derived from primary lung epithelial cells of C57BL/6 mice and immortalized with human papilloma virus (HPV)-16 E6/E7 oncogenes, are often used to establish cervical cancer mouse model [ 71 ]. After the formation of tumors, mice were intratumorally injected with AT-MSC HSVtk , followed by intraperitoneally administration of GCV after 14 days.…”

Section: Msc-based Therapies In Gynecologic Cancersmentioning

confidence: 99%

Emerging role of mesenchymal stromal cells in gynecologic cancer therapy

Song,

Liu,

Pan

et al. 2023

Stem Cell Res Ther

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Mesenchymal stromal cells (MSCs) show considerable promise in regenerative medicine with superior anti-fibrotic, immunomodulatory, and angiogenic functions. More recently, discovered with the tumor tropism, MSCs have been exploited as the basis of targeted cancer therapy. In this scenario, MSCs can directly home to tumor tissues and play anti-tumor properties. In addition, MSCs, MSC-derived exosomes and MSC-derived membranes are often developed as carriers for precisely delivering cytotoxic agents to cancer sites, including chemotherapeutic drugs, therapeutic genes, or oncolytic viruses. However, it has revealed the tumorigenic risk of MSCs as an important component within the tumor microenvironment, hampering the translation of MSC-based cancer therapies into clinical settings. Therefore, in this review, we introduce the specific tumor-tropic ability of MSCs and underlying mechanisms. We also summarize the current application of MSC-based therapeutic approaches in treating gynecologic cancers, mainly including cervical, ovarian, and endometrial cancers. Moreover, we discuss the main challenges that the current MSC-based cancer therapies are facing.

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Enhanced population of excited single state strategy: irradiation and ultrasound dual-response and host tumor-driven nano-sensitizers construction in triple synergistic therapy

Li,

Tian,

Yang

et al. 2024

Nano Res.

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Photo-sonodynamic therapy mediated with OLI_NPs to induce HPV16E7-specific immune response and inhibit cervical cancer in a Tc-1-grafted murine model

Cited by 4 publications

References 52 publications

Monitoring of singlet oxygen generation of a novel Schiff-base substituted silicon phthalocyanines by sono-photochemical studies and in vitro activities on prostate cancer cell

Monitoring of singlet oxygen generation of a novel Schiff-base substituted silicon phthalocyanines by sono-photochemical studies and in vitro activities on prostate cancer cell

Emerging role of mesenchymal stromal cells in gynecologic cancer therapy

Enhanced population of excited single state strategy: irradiation and ultrasound dual-response and host tumor-driven nano-sensitizers construction in triple synergistic therapy

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