Abstract:Kif18A is a member of the kinesin-8 family was identified as a central component for the correct alignment of chromosomes at the spindle equator. Recent in vitro analyses revealed that Kif18A has a unique dual functionality, motility and depolymerase. Previously, BTB-1 was found to be the first small molecule inhibitor of Kif18A. BTB-1 potently inhibits the ATPase activity of Kif18A (IC50=1.69 mm) but not of other tested key mitotic kinesins. BTB-1 blocks the motility of Kif18A in a reversible manner. BTB-1 in… Show more
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